Heme Onc 2

Question 1

Hb 7-8, indications for blood transfusion

Answer 1

cardiac surgery
heart failure
oncology patient in tx

Question 2

Hb 8-10 indications for blood transfusion

Answer 2

symptomatic anemia
ongoing bleeding
ACS
noncardiac surgery

Question 3

both B12 and folate convert…

Answer 3

homocysteine to methionine

so deficiencies lead to elevated homocysteine

Question 4

TTP peripheral blood smears show

Answer 4

schistocytes

Question 5

hereditary spherocytosis causes what type of gallstones

Answer 5

pigment gallstones

Question 6

hereditary spherocytosis requires supplementation of

Answer 6

folate

Question 7

does your body have lower stores of B12 or folate?

Answer 7

folate

Question 8

pernicious anemia causes what type of vitamin deficiency

Answer 8

B12 deficiency

Question 9

myelodysplastic syndrome labs

Answer 9

pancytopenia

macrocytosis

Question 10

positive fibrin degradation products signify

Answer 10

DIC

Question 11

myelocytes and metamyelocytes… differential and how to differentiate the two

Answer 11

leukemoid reaction vs CML
leukemoid reaction: more mature, so more metamyelocytes than myelocytes, high alk phos
CM: less mature, so less metamyelocytes than myelocytes, low alk phos

Question 12

vegetarian anemia

Answer 12

B12, after about 3-4 years

Question 13

poor diet anemia

Answer 13

folate

Question 14

fatigue, SOB, URI treated with amoxicillin, splenomegaly, anemia, reticulocytosis

• dx
• tx

Answer 14

autoimmune hemolytic anemia

glucocorticoids

Question 15

CHOP therapy is used to treat

Answer 15

non Hodgkins lymphoma

Question 16

B12 deficiency can be caused by

Answer 16

pernicious anemia
short bowel syndrome
vegan

Question 17

MCV / RBC (Mentzner index) less than 13

Answer 17

thalassemia

Question 18

MCV / RBC (Mentzner index) greater than 13

Answer 18

iron deficiency anemia (b/c decr RBC)

Question 19

von willebrand disease labs

Answer 19

incr bleeding time and PTT

normal PT

Question 20

factor 8 deficiency labs

Answer 20

prolongs PTT

Question 21

qualities of gloms tumor

Answer 21

tender
sensitivity to touch
intermitent pain

Question 22

dx testicular tumor on US. next step

Answer 22

radical orchiectomy

Question 23

traztuzumab cuases ___

and next step

Answer 23

cardiotoxicity

echo

Question 24

peripheral smear of ITP

Answer 24

megakaryocytes

Question 25

management of adult with ITP

Answer 25

if platelets less than 30,000 or bleeding, IVIG or glucocorticoids if not, obs

Question 26

sxs of Bernard Soulier

Answer 26

bleeding out of proportion to the mild thrombocytopenia

Question 27

labs of DIC

Answer 27

low platelets | incr PT and PTT

Question 28

labs of vWD

Answer 28

incr bleeding time and PTT

Question 29

labs of hemophilia

Answer 29

incr PTT

Question 30

management of heparin induced thrombocytopenia

Answer 30

stop heparin | dx with serotonin release assay OR start argatroban or fondaparinux