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Flashcards in Heme / Onc Deck (30):
1

macrocytic anemia in sickle cell patient is from

folate deficiency
could also be from hydroxyurea

2

indications for hyper coagulability testing

Less than 45 yrs old
family history
recurrent or unusual site of VTE

3

incr AFP and bHCG

nonseminomatous germ cell tumor
- yolk sac tumor
- choriocarcinoma
- embryonal carcinoma

4

differential for anterior mediastinal mass

thymoma
teratoma
thyroid neoplasm
terrible lymphoma

5

palpable venous cords
- syndrome name
- what cancers
- next step

migratory superficial thrombophlebitis / Trousseau syndrome
pancreas, stomach, lung, colon, acute leukemias
CT abd

6

heavy smoking, abdominal pain, superficial thrombophlebitis
- dx
- next step

pancreatic ca
CT abd

7

characteristics of Leydig cell tumors

high estrogen
low LH and FSH
gynecomastia

8

diarrhea, steatorrhea, ulcers distal to duodenum

zollinger ellison syndrome (gastrin producing tumor)

9

most common cause of anemia in alcoholics

folate deficiency

10

Pappenheimer bodies associated with

sideroblastic anemia

11

hypothyroidism associated with what type of anemia

macrocytic anemia

12

GI malabsorption causes what type of anemia

iron deficiency anemia

13

tx for Diamond blackfan anemia

corticosteroids
if doesn't work: transfusion

14

diamond blacken: type of anemia

macrocytic (but don't see hyperseg neutrophils)

15

other congenital abnormalities of diamond blackfan anemia

shield chest
webbed neck
triphalangeal thumbs
short stature
cleft lip

16

tumor in females that produce a lot of estrogen and can cause precocious puberty or postmenopausal bleeding

granulosa cell tumor

17

tumor producing androgens, causing masculinization of females

sertoli-leydig cell tumor

18

characteristics of mets to bone

age greater than 50
worse at night
wt loss
cauda equina syndrome (weakness, urine incontinence/retention, saddle anesthesia)

19

end stage renal failure and a lot of bleeding (nosebleeds, ecchymoses, GI bleeds, etc)
- dx
- pathology
- labs
- tx

uremic coagulopathy
dysfunctional platelets
bleeding time high (all else like PT and PTT normal)
DDAVP

20

iron deficiency anemia in male or postmenopausal female. next step?

test occult blood to r/o GI causes of blood loss

21

burr cells / echinocytes (serrated edges).. differential

liver dz
ESRD

22

spur cells / acanthocytes seen in

liver dz

23

target cells.. differential

thalassemia
obstructive liver dz

24

hereditary spherocytosis
- lab findings
- tx
- complications

Lab:
neg coombs
incr MCHC
osmotic fragility on acidified glycerol lysis test
abnormal EMB test

Tx:
folic acid, blood transfusions, splenectomy

complications:
pigmented gallstones, Parvo B19 infxns

25

indications for erythropoeitin

chronic renal failure and Hb less than 10%, with iron deficiency ruled out (if have IDA, give iron first)

hemodialysis patient with sxs attributed to anemia

26

side effects of erythropoeitin

HTN
HA
flu- like sxs
red cell aplasia

27

hypochromic and normochromic RBCs

acquired sideroblastic anemia (ex: from INH in TB tx without B6)

28

peripheral smear of CLL

many small lymphocytes
smudge cells

29

characteristics of CML

incr WBC, more than 100,000
incr basophils and neutrophils (myelocytes)
splenomegaly
incr plts
anemia

30

sxs of hemochromatosis

cirrhosis
heart failure
DM
hypogonadism
arthritis