Hemeonc p. 382-386

Question 1

Life span of RBC?

Answer 1

120 days

Question 2

Life span of platelet?

Answer 2

8–10 days

Question 3

Normally leukocyte count range?

Answer 3

4000–10,000 cells/mm3.

Question 4

Membrane of RBC contains — antiporter,

Answer 4

Cl−/HCO3

Question 5

Name the vWF receptor?

Answer 5

GpIb

Question 6

Erythrocytosis = — = —- hematocrit

Answer 6

polycythemia

incr

Question 7

Dense granules in Platelets contain —- and α granules contain —.

Answer 7

ADP, Ca2+

vWF, fibrinogen

Question 8

Normal Basophils %?

Answer 8

(0–0.75%)

Question 9

Poikilocytosis =

Answer 9

varying shapes

Question 10

Name Fibrinogen receptor?

Answer 10

GpIIb/IIIa.

Question 11

Neutrophyls specific granules contain 4 components: “CALL”

Answer 11

ALP
collagenase
lysozyme
lactoferrin (traps iron)

Question 12

What are Azurophilic granules?

Answer 12

lysosomes

Question 13

Anisocytosis =

Answer 13

varying sizes (seen in thalasemia, spherocytosis)

Question 14

Azurophilic granules contain what 4 components?

Answer 14

proteinases
phosphatase
myeloperoxidase
β-glucuronidase (in liver)

Question 15

Important neutrophil chemotactic agents:

Answer 15

C5a,
IL-8, 
LTB4, 
kallikrein, 
platelet-activating factor

Question 16

How does gram neg bacteria initiate septic shock?

Answer 16

Lipid A from bacterial LPS binds CD14 on macrophages

Question 17

Incr in myeloid proliferation is observed by the incr of what cells during infection or CML?

Answer 17

band cells (immature neutrophils)

Question 18

Macrophages are activated by

Answer 18

γ-interferon.

Question 19

Which 2 cells are packed with basophylic granules?

Answer 19

Basophyls

Mast cell

Question 20

Monocytes differentiates into —- in tissues.

Answer 20

macrophage

Question 21

Macrophages are antigen-presenting cell via —.

Answer 21

MHC II.

Question 22

Extensive “frosted glass” cytoplasm referrers to what type of cells?

Answer 22

Monocyte

Question 23

Basophilia is uncommon, but can be a sign of what path?

Answer 23

myeloproliferative disease, particularly CML.

Question 24

Which cells expresses MHC class II and Fc receptors on surface?

Answer 24

Dendritic cell, macrophage

Question 25

Which kind of Leukocyte | produces histaminase and major basic protein?

Answer 25

Eosinophil

Question 26

Round, densely staining nucleus with small amount of pale cytoplasm describes what type of cells?

Answer 26

Lymphocyte

Question 27

Name the 5 causes of eosinophilia "A PAC A DNA"

Answer 27

``` Drug: macrolides, NSAID Neoplasia Asthma Aspergillus inf Acute interstitual nephritis Allergic processes Chronic adrenal insufficiency, Collagen vascular dz Parasites (invasive) ```

Question 28

--- is a costimulatory signal necessary for T-cell activation.

Answer 28

CD28

Question 29

Which type of cells have abundant RER, and well developed Golgi apparatus?

Answer 29

Plasma cells

Question 30

Which Leukocyte contains Heparin?

Answer 30

Basophil, Mast cells

Question 31

Which type of blood is a Universal recipient of plasma?

Answer 31

O type

Question 32

“Clock-face” chromatin distribution refers to what type of cells?

Answer 32

Plasma cells

Question 33

If ---- type pt receives type A or AB it will cause hemolytic reaction.

Answer 33

B type

Question 34

mothers exposed to fetal Rh+ blood (often during delivery) may make what type of Ab?

Answer 34

anti-D IgG.

Question 35

Which plasma type is a Universal donor of plasma?

Answer 35

AB type

Question 36

If ---- type pt receives any non-O type it will cause hemolytic reaction.

Answer 36

O type

Question 37

---- administration to Rh− pregnant women during -----, which prevents maternal anti-Rh IgG production.

Answer 37

RhoGAM | third trimester

Question 38

Hemophilia C has a deficiency of what factor? And what is the genetic inheritance?

Answer 38

XI (AR)

Question 39

Name to LMWH?

Answer 39

dalteparin, enoxaparin, Fondaparinux

Question 40

---- activates bradykinin; --- inactivates bradykinin

Answer 40

Kallikrein (HMWK) | ACE

Question 41

The LMWH have the greatest e€efficacy on which factor?

Answer 41

factor Xa

Question 42

Which 3 tissue factors require Ca2+ and phospholipid?

Answer 42

Thromboplastin (III) (produced from fetus during abortion) Va VIIIa

Question 43

Which 4 tissue factors are inhibited by vitamin K antagonist warfarin?

Answer 43

II VII IX X

Question 44

Heparin has the greatest e€efficacy on which factor?

Answer 44

IIa (thrombin)

Question 45

Which 2 coagulation factors are cofactors?

Answer 45

Va | VIIIa

Question 46

T or F? Plasmin activates but is not part of coagulation cascade.

Answer 46

T

Question 47

Name 3 direct thrombin inhibitors? (DOC for HIT)

Answer 47

argatroban bivalirudin dabigatran

Question 48

Name 2 direct Xa inhibitors?

Answer 48

apixaban, rivaroxaban

Question 49

Fondaparinux inhibits which factor? (it causes HIT)

Answer 49

factor Xa

Question 50

Thrombin converts what to what?

Answer 50

Fibrinogen to Fibrin monomers

Question 51

phytomenadione or phylloquinone or phytonadione help mature which factors?

Answer 51

Vit K helps the maturation of clotting factors II, VII, IX, X, and proteins C and S.

Question 52

Prolonged use of broad-spectrum antibiotics can cause what?

Answer 52

hemorrhagic disease due to vit K def

Question 53

Which complex activates protein C?

Answer 53

Thrombin-thrombomodulin complex

Question 54

---- stabilizes platelet plug.

Answer 54

Fibrin mesh

Question 55

Name the enzyme that produces reduced vit K?

Answer 55

Epoxide reductase

Question 56

----- cleaves and inactivates Va, VIIIa

Answer 56

Protein S

Question 57

Warfarin inhibits the enzyme vitamin K ----.

Answer 57

epoxide reductase.

Question 58

Describe the Factor V Leiden mutation?

Answer 58

it produces a factor V resistant to inhibition by activated protein C.

Question 59

Plasminogen ---> plasmin

Answer 59

tPA

Question 60

Drug used for asthma prophylaxis? And MOA?

Answer 60

Cromolyn sodium prevents mast cell degranulation

Question 61

Basophils is incr in what path?

Answer 61

Chronic myelogenous leukemia (CML) | polycythemia

Question 62

Eosonophis are incr in what infections?

Answer 62

Aspergillus infecetion | parasites

Question 63

Which T cells recruit eosonophils?

Answer 63

Th2 cell

Question 64

Eosinophylic infiltrate is see in what cardiac path?

Answer 64

Löffler syndrome (endomyocardial fibrosis with a prominent eosinophilic infiltrate), Eosinophilic granulomatosis with polyangiitis (Churg- Strauss)

Question 65

Eosinophila in what 2 drugs?

Answer 65

Macrolides, NSAIDS

Question 66

What vit def. enhances vit k def. in bleeding?

Answer 66

vit E

Question 67

what blocks tPA?

Answer 67

Trunexemic, Aminocaproic acid