Hemonc 412,413 Flashcards Preview

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Flashcards in Hemonc 412,413 Deck (17):
1

What are the 2 most commonly used glucocorticoids in cancer chemotherapy?

Prednisone, prednisolone

2

Diabetic retinopathy is treated with what Monoclonal antibody?

Bevacizumab -> anti- VEGF

3

Tx of Adenocarcinoma of the lung and MOA?

Erlotinib: EGFR tyrosine kinase inhibitor

4

Rituximab inhibits which CD?

CD20

5

Pt that has been treated with BCR-ABL mutation presents with edema, what was the Tx?

Imatinib - Fluid retention.

6

What drug would you use to treat a 68 year old female with breast ca?

Raloxifene, useful to prevent osteoporosis.

7

HER-2 (c-erbB2) is what kind of receptor?

tyrosine kinase receptor

8

Which Tx blocks the binding of estrogen to ER ⊕ cells?

(SERMs)—receptor antagonists in breast

9

Tx and MOA that treats Metastatic melanoma?

Vemurafenib
Small molecule inhibitor of BRAF oncogene ⊕ melanoma

10

Which anti-inflam drugs can cause cataracts, acne, hypertension, peptic ulcers and psychosis?

Prednisone, prednisolone

11

Pt undergoing Tx for B-cell neoplastic presents with nonenhancing areas of demyelination on MRI. What was the Tx that caused this?

Rituximab due to developement of progressive multifocal leukoencephalopathy

12

Toxicity of Herceptin?

Cardiotoxicity

13

SE: of EGFR tyrosine kinase inhibitor?

rash, photosen.

14

(SERMs)—receptor antagonists of the breast causes an incr risk of endometrial cancer?

Tamoxifen

15

This drugs SE are similar to a dz that is caused by shistosomiasis?

CYclophosphamide--> hemorrhagic cystitis

16

Pt in chemotherapy acquires hearing loss, what was the Tx?

Cisplatin/Carboplatin

17

3 chemo drugs where pts need to be cautious to prevent infections?

myelosuppression cause by:
5-FU Ž
6-MP Ž
Busulfan
Cladribine
Methotrexate