Neuro p. 500-502 Flashcards Preview

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Flashcards in Neuro p. 500-502 Deck (14)
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1
Q

BALSA mneumonic stands for what? It treats what?

A

Parkinsons

Bromocriptine
Amantadine
Levodopa (with carbidopa)
Selegiline (and COMT inhibitors)
Antimuscarinics
2
Q

Pt suffering from Parkinson for a decade presents with atrial fibrillation and diminished voluntary movements following administration of the medicine but postural instability in between. what medication is he on?

A

l-dopa (levodopa)/carbidopa

3
Q

Name a NMDA receptor antagonist that helps prevent excitotoxicity (mediated by Ca2+)?

A

Memantine used for Alzheimer

4
Q

Name 2 Non-ergot (preferred) Tx for Parkinson?

A

pramipexole (restless leg syn Tx), ropinirole

5
Q

Pt with dec GABA, decr  ACh, incr dopamine is prescribed a drug that inhibits VMAT. Name the drug and its use?

A

Tetrabenazine (tx Turetts)

Tx of Huntington disease

6
Q

The drug that treats “1 Big Damn Headache” is contraindicated in which pts?

A

Triptans - 5-HT1B/1D agonists

patients with CAD or Prinzmetal angina

7
Q

Which drug incr dopamine release and decr reuptake?

A

Amantadine

8
Q

MOA of galantamine?

A

AChE inhibitors

9
Q

Which drug can be used both in Schizophrenia (primarily positive symptoms) and Huntington dz?

A

ƒHaloperidol—D2 receptor antagonist

10
Q

Which agent blocks DOPA decarboxylase?

A

carbidopa

11
Q

Which drugs prevent peripheral l-dopa degradation to 3-O-methyldopa (3‑OMD) by inhibiting COMT?

A

Entacapone, tolcapone

12
Q

Drug that blocks conversion of dopamine into 3-MT by selectively inhibiting MAO-B?

A

Selegiline

13
Q

2 MOA of Tolcapone

A

—blocks conversion of dopamine to DOPAC by inhibiting central COMT
—prevent peripheral l-dopa degradation to 3-O-methyldopa (3‑OMD) by inhibiting COMT.

14
Q

Which Tx improves tremor and rigidity but has little effect on bradykinesia?

A

Benztropine/ Antimuscarinic (Tx for drug-induced Parkinson)