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M2015/16 > Immuno p.218-220 > Flashcards

Immuno p.218-220 Flashcards

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1
Q

Blocks T-cell activation by preventing IL-2 transcription?

A

Cyclosporine

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2
Q

Tx for rheumatoid arthritis, Crohn disease and glomerulonephritis?

A

Azathioprine

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3
Q

Drug that is a mTOR inhibitor?

A

Sirolimus (Rapamycin

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4
Q

SE of which Immunosuppressants cause edema, hypertension, tremor?

A

Daclizumab, basiliximab

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5
Q

SE of which Immunosuppressants cause hypertension,

cataracts, avascular necrosis?

A

Glucocorticoids

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6
Q

Monoclonal antibodies that block IL-2R?

A

Daclizumab, basiliximab

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7
Q

Calcineurin inhibitor that binds FK506 binding

protein (FKBP)?

A

Tacrolimus (FK506)

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8
Q

SE of Tacrolimus?

A

 risk of diabetes and neurotoxicity

Nephrotoxic

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9
Q

Drug that is also used in drugeluting stents?

A

Sirolimus (Rapamycin)

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10
Q

Which Immunosuppressants causes gingival hyperplasia and hirsutism, nephrotoxicity?

A

Cyclosporine

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11
Q

SE of both calcineurin inhibitors?

A

highly nephrotoxic.

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12
Q

Epoetin alfa is used for?

A

Anemias (especially in renal failure)

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13
Q

Oprelvekin is which IL?

A

IL-11

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14
Q

Tx for Multiple sclerosis?

A

IFN-β

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15
Q

Difference between Filgrastim and

Sargramostim used for recovery of bone marrow?

A

Filgrastim (G-CSF)

Sargramostim (GM-CSF)

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16
Q

Recombinant cytokine used for renal cell carcinoma and metastatic melanoma?

A

Aldesleukin (IL-2)

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17
Q

Tx for Chronic hepatitis B and C, Kaposi sarcoma,

malignant melanoma?

A

IFN-α

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18
Q

Rituximab targets:

A

CD20

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19
Q

Trastuzumab targets:

A

HER2/neu

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20
Q

Cetuximab targets:

A

EGFR

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21
Q

Alemtuzumab targets:

A

CD52

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22
Q

Bevacizumab targets:

A

VEGF

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23
Q

Natalizumab targets:

A

α4-integrin

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24
Q

Eculizumab targets:

A

Complement protein C5

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25
VEGF is targeted by 2 drugs:
Bevacizumab, Ranibizumab
26
Denosumab targets:
RANKL
27
Abciximab targets:
Platelet glycoproteins IIb/IIIa
28
Palivizumab targets:
RSV F protein
29
Adalimumab, Certolizumab, Infliximab target:
Soluble TNF-α
30
Abciximab targets:
Platelet glycoproteins IIb/IIIa
31
All TNF-α inhibitors predispose to infection, including reactivation of ----, since TNF is important in ----- formation and stabilization.
latent TB | granuloma
32
---- is a Fusion protein (receptor for TNF-α + IgG1 Fc), | produced by recombinant DNA.
Etanercept
33
2 Therapeutic antibodies against CLL?
Alemtuzumab, Rituximab
34
Therapeutic antibodies against dz that has lost the APC gene function?
Bevacizumab, Cetuximab
35
Therapeutic antibodies against cancer that has lost VHL gene func?
Bevacizumab
36
Therapeutic antibodies against head and neck ca?
Cetuximab
37
Therapeutic antibodies against B-cell non-Hodgkin | lymphoma,?
Rituximab
38
3 Therapeutic antibodies against rheumatoid | arthritis?
Rituximab Adalimumab Certolizumab Infliximab
39
Therapeutic antibodies against psoriasis, ankylosing spondylitis?
Adalimumab Certolizumab Infliximab
40
Therapeutic antibodies against Neovascular age-related | macular degeneration?
Ranibizumab | Bevacizumab
41
Therapeutic antibodies against Allergic asthma; prevents IgE binding to FcεRI?
Omalizumab
42
Therapeutic antibodies against Multiple sclerosis?
Natalizumab
43
Therapeutic antibodies against Paroxysmal nocturnal | hemoglobinuria?
Eculizumab
44
Therapeutic antibodies against Antiplatelet agent for prevention of ischemic complications in patients undergoing percutaneous coronary stenting?
Abciximab
45
Therapeutic antibodies against Breast cancer?
Trastuzumab
46
Therapeutic antibodiesthat inhibits osteoclast | maturation (mimics osteoprotegerin)?
Denosumab
47
T or F? Etanercept is a decoy TNF-α receptor and a monoclonal antibody.
F. It is NOT a monoclonal antibody.
48
2 Therapeutic antibodies against Crohn disease/IBD?
Natalizumab | Adalimumab, infliximab
49
Therapeutic antibodies for RSV prophylaxis for high-risk infants?
Palivizumab
50
Which Therapeutic antibodies causes WBC adhesion and Risk of PML in patients with JC virus?
Natalizumab
51
Which 2 drugs inhibit the formation of NFAT–P into NFAT?
Calcineurin inhibitors: Cyclophilin + Cyclosporine FKBP + Tacrolimus
52
Immunosuppressant that inhibit PRPP amidotransferase indirectly?
Azathioprine
53
Which immunosuppressant causes apoptosis of T cells?
Glucocorticoids
54
Mycophenolate, Mofetil MOA?
reversibly inhibits IMP dehydrogenase => prevent purine synth of B and T cells.
55
Which 3 immunosuppressants cause hyperglycemia?
Mycophenolate, Mofetil | Glucocorticoids
56
MOA of Glucocorticoids?
Inhibits NF-kB => decr cytokines transcription => decr T and B cell function.
57
Which immunosup. causes pancytopenia?
Mycophenolate, Mofetil
58
Which 3 immunosup. causes IL-2 response and which causes IL-2 transcription?
Preventing IL-2 response --> Sirolimus | Preventing IL-2 transcription --> Cyclosporin, Tacrolimus
59
Which 2 immunosup. cause hyperlipidemia?
Sirolimus | Cyclosporin
60
Which 3 immunosup. causes pancytopenia?
Azathioprine | Mycophenolate, Mofetil
61
Name the drug that is a thrombopoetin receptor agonist?
Eltrombopag
62
3 drugs that treat thrombocytopenia?
Romiplostim Eltrombopag Oprelvekin "REOcytopenia"

M2015/16 (27 decks)

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