Micro p.162-166

Question 1

Neg stranded RNA virus must have what in order to replicate?

Answer 1

its own RNA-dependent RNA polymerase

Question 2

6 Neg stranded RNA virus are:

“Always Bring Polymerase Or Fail Replication”

Answer 2

Arenaviruses, 
Bunyaviruses,
Paramyxoviruses, 
Orthomyxoviruses,
Filoviruses, 
Rhabdoviruses

Question 3

T or F? Segmented viruses are all RNA viruses.

Answer 3

T

Question 4

Which viruses are able to mutate frequently?

“BOAR “

Answer 4

Segmented viruses:
Bunyaviruses, 
Orthomyxoviruses (influenza
viruses), 
Arenaviruses,
Reoviruses

Question 5

All Picornavirus are enteroviruses (fecal-oral spread) except

Answer 5

rhinovirus

Question 6

Picornavirus can cause aseptic (viral) meningitis except for?

Answer 6

rhinovirus and HAV

Question 7

Picornavirus includes:

Answer 7

Poliovirus, Echovirus, Rhinovirus,

Coxsackievirus, and HAV

Question 8

Which Picornavirus is destroyed by stomach acid?

Answer 8

Rhinovirus

Question 9

Symptoms of high fever, black vomitus, and
jaundice and eosinophilic apoptotic globules on liver
biopsy may be seen with which virus?

Answer 9

Yellow fever virus

Councilman bodies

Question 10

Yellow fever virus has a reservoir of 2?

Answer 10

monkey or human

Question 11

Yellow fever virus is transmitted by?

Answer 11

Aedes mosquitoes

Question 12

Which virus causes global infantile gastroenteritis, and is a segmented dsRNA virus?

Answer 12

Rotavirus (a reovirus).

Question 13

What time of the year in the United States is acute diarrhea prevelant and at which public ares?

Answer 13

during winter

day care centers, kindergartens

Question 14

Rotavirus destroys which part of the intestine causing diarrhea? what gets lost?

Answer 14

Villous atrophy leads to absorption of Na+ and loss of K+.

Question 15

Which viral infection can result in pulsus paradoxus 2°

to upper airway obstruction?

Answer 15

Severe croup

Question 16

What is Steeple sign and where is it seen?

Answer 16

Narrowing of upper trachea and subglottis on x-ray of neck

croup

Question 17

Vitamin A supplementation can reduce which viral infection’s mortality in malnourished or vitamin-deficient
children?

Answer 17

Measles

Question 18

Lymphadenitis with Warthin-Finkeldey giant

cells is seen in?

Answer 18

Measles

Question 19

Pathology that is rarely seen in immunosuppressed pts with Measles?

Answer 19

giant cell pneumonia

Question 20

T or F? Koplik spots follows the measles rash by 1–2

days.

Answer 20

F, it precedes it

Question 21

What path can occur years later after Measles infection?

Answer 21

subacute sclerosing panencephalitis,

Question 22

H. influenza virus contain 2 types of antigens called? .

Answer 22

hemagglutinin

neuraminidase

Question 23

H. influenza virus antigens: hemagglutinin promotes —- and

neuraminidase promotes —- .

Answer 23

viral entry

progeny virion release

Question 24

How does H. influenza v. cause a drift?

Answer 24

An antigenic drift causes changes based on random mutation in hemagglutinin or neuraminidase genes.

Question 25

How does H. influenza v. cause pandemics?

Answer 25

Reassorts it's viral genome segments, such as when segments of human flu A virus reassort with swine flu A virus.

Question 26

which 2 viral infections can predispose pt to superinfections?

Answer 26

H. influenza v., HBV (p166)

Question 27

A “blueberry muffin” appearance with congenital rubella findings is indicative of?

Answer 27

extramedullary hematopoiesis

Question 28

30 year old male remembers acquiring aseptic meningitis as a child, which might be related to his infertility. what is the causal virus?

Answer 28

``` Mumps virus (maybe do to Orchitis: inflammation of testes), ```

Question 29

Why is H. influenza Live attenuated vaccine administered intranasally?

Answer 29

Because it contains temperature sensitive mutant that replicates in the nose but not in the lung

Question 30

Paramyxoviruses contain --------- , which | causes respiratory epithelial cells to fuse and form multinucleated cells.

Answer 30

surface F (fusion) protein

Question 31

Pt who is unable to swallow his saliva do to hydrophobia might have what viral infection?

Answer 31

Rabies virus

Question 32

Negri bodies are commonly found in 2 places:

Answer 32

Purkinje cells of cerebellum and in hippocampal neurons

Question 33

3 cell types that Ebola virus targets:

Answer 33

targets: endothelial cells phagocytes hepatocytes

Question 34

key to preventing Ebola transmission is:

Answer 34

Strict isolation of infected individuals and | barrier practices for health care workers

Question 35

All Hepatitis viruses are RNA except for:

Answer 35

HBV

Question 36

T or F? Pt infected with rabies start showing symptoms in less than a week.

Answer 36

Rabies has long incubation period (weeks to | months) before symptom onset.

Question 37

2 hepatitis viruses that use the Fecal-oral rout for transmission:

Answer 37

HAV | HEV

Question 38

Which hep virus uses a DNA polymerase that has both DNA- and RNA-dependent activities

Answer 38

HBV

Question 39

Which hep virus is Primarily transmitted through | IVDU, posttransfusion?

Answer 39

HCV

Question 40

Hep virus causing high mortality in pregnant women?

Answer 40

HEV

Question 41

Which 2 hep viruses are transmitted parenteral, | sexual and perinatal?

Answer 41

HBV, HDV