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M2015/16 > Micro p.162-166 > Flashcards

Micro p.162-166 Flashcards

1
Q

Neg stranded RNA virus must have what in order to replicate?

A

its own RNA-dependent RNA polymerase

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2
Q

6 Neg stranded RNA virus are:

“Always Bring Polymerase Or Fail Replication”

A 
Arenaviruses, 
Bunyaviruses,
Paramyxoviruses, 
Orthomyxoviruses,
Filoviruses, 
Rhabdoviruses
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3
Q

T or F? Segmented viruses are all RNA viruses.

A

T

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4
Q

Which viruses are able to mutate frequently?

“BOAR “

A 
Segmented viruses:
Bunyaviruses, 
Orthomyxoviruses (influenza
viruses), 
Arenaviruses,
Reoviruses
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5
Q

All Picornavirus are enteroviruses (fecal-oral spread) except

A

rhinovirus

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6
Q

Picornavirus can cause aseptic (viral) meningitis except for?

A

rhinovirus and HAV

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7
Q

Picornavirus includes:

A

Poliovirus, Echovirus, Rhinovirus,

Coxsackievirus, and HAV

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8
Q

Which Picornavirus is destroyed by stomach acid?

A

Rhinovirus

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9
Q

Symptoms of high fever, black vomitus, and
jaundice and eosinophilic apoptotic globules on liver
biopsy may be seen with which virus?

A

Yellow fever virus

Councilman bodies

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10
Q

Yellow fever virus has a reservoir of 2?

A

monkey or human

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11
Q

Yellow fever virus is transmitted by?

A

Aedes mosquitoes

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12
Q

Which virus causes global infantile gastroenteritis, and is a segmented dsRNA virus?

A

Rotavirus (a reovirus).

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13
Q

What time of the year in the United States is acute diarrhea prevelant and at which public ares?

A

during winter

day care centers, kindergartens

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14
Q

Rotavirus destroys which part of the intestine causing diarrhea? what gets lost?

A

Villous atrophy leads to absorption of Na+ and loss of K+.

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15
Q

Which viral infection can result in pulsus paradoxus 2°

to upper airway obstruction?

A

Severe croup

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16
Q

What is Steeple sign and where is it seen?

A

Narrowing of upper trachea and subglottis on x-ray of neck

croup

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17
Q

Vitamin A supplementation can reduce which viral infection’s mortality in malnourished or vitamin-deficient
children?

A

Measles

18
Q

Lymphadenitis with Warthin-Finkeldey giant

cells is seen in?

A

Measles

19
Q

Pathology that is rarely seen in immunosuppressed pts with Measles?

A

giant cell pneumonia

20
Q

T or F? Koplik spots follows the measles rash by 1–2

days.

A

F, it precedes it

21
Q

What path can occur years later after Measles infection?

A

subacute sclerosing panencephalitis,

22
Q

H. influenza virus contain 2 types of antigens called? .

A

hemagglutinin

neuraminidase

23
Q

H. influenza virus antigens: hemagglutinin promotes —- and

neuraminidase promotes —- .

A

viral entry

progeny virion release

24
Q

How does H. influenza v. cause a drift?

A

An antigenic drift causes changes based on random mutation in hemagglutinin or neuraminidase genes.

25
Q

How does H. influenza v. cause pandemics?

A

Reassorts it’s viral genome segments, such as when segments of human flu A virus reassort with swine flu A
virus.

26
Q

which 2 viral infections can predispose pt to superinfections?

A

H. influenza v., HBV (p166)

27
Q

A “blueberry muffin” appearance with congenital rubella findings is indicative of?

A

extramedullary hematopoiesis

28
Q

30 year old male remembers acquiring aseptic meningitis as a child, which might be related to his infertility. what is the causal virus?

A 
Mumps virus (maybe do to Orchitis: inflammation
of testes),
29
Q

Why is H. influenza Live attenuated vaccine administered intranasally?

A

Because it contains temperature sensitive
mutant that replicates in the nose but
not in the lung

30
Q

Paramyxoviruses contain ——— , which

causes respiratory epithelial cells to fuse and form multinucleated cells.

A

surface F (fusion) protein

31
Q

Pt who is unable to swallow his saliva do to hydrophobia might have what viral infection?

A

Rabies virus

32
Q

Negri bodies are commonly found in 2 places:

A

Purkinje cells of cerebellum and in hippocampal neurons

33
Q

3 cell types that Ebola virus targets:

A

targets:
endothelial cells
phagocytes
hepatocytes

34
Q

key to preventing Ebola transmission is:

A

Strict isolation of infected individuals and

barrier practices for health care workers

35
Q

All Hepatitis viruses are RNA except for:

A

HBV

36
Q

T or F? Pt infected with rabies start showing symptoms in less than a week.

A

Rabies has long incubation period (weeks to

months) before symptom onset.

37
Q

2 hepatitis viruses that use the Fecal-oral rout for transmission:

A

HAV

HEV

38
Q

Which hep virus uses a DNA polymerase that has both DNA- and RNA-dependent activities

A

HBV

39
Q

Which hep virus is Primarily transmitted through

IVDU, posttransfusion?

A

HCV

40
Q

Hep virus causing high mortality in pregnant women?

A

HEV

41
Q

Which 2 hep viruses are transmitted parenteral,

sexual and perinatal?

A

HBV, HDV

M2015/16 (27 decks)

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