Herpies Viruses Flashcards
(99 cards)
What type of VIrus are Herpes Simple Virus Type 1 and Type 2 (HSV-1 and HSV-2)
Alphaherpesciridae (like varicella Zoster virus)
Host range of Alphaherpesvirus
Variable host range
Length of reproduction cycle of Alphaherpesvirus
Short
speed of culture spread of Alphaherpesvirus
Rapid Spread
Descruction efficiency of infected cells by Alphaherpesvirus
Efficient destruction (cyototix-can lyse cells)
where can Alphaherpesvirus establish latency
In sensory ganglia
Herpies virus type I infects where
waste up
Herpies virus Type II infects where
waste down
how does HSV-1 infect
oral-oral, oral-genital
amount of adults that are seropositive for HSV-1
nearly 2/3
How does HSV-2 infect
Primarily genital-genital, also oral-genital possible
prevealent with sexual activity
amount of adults with HSV-2
1/5 of adults are infected
where does HSV-1 and HSV-2 infected
Epithelial cells in the skin or mucosa (mucosa more susceptible)
Incubation of HSV-1 and 2
2-14 days, but typically 4-5 days
Symptoms of HSV 1 and 2
Flu-like, includes localized lesions (virus spreads to neighboring cells primarily)
who shows symptoms of HSV-1 and 2
1/3
can asymptomatic people transmit HSV-1 and 2
yes
how long does the Symptoms of HSV 1 and 2 last
8-12 days
Latency of Alphaherpesvirus occures where
In stationary cells
peripheral ganglia common site of latent infections
what occures in latency of Alphaherpesvirus
Genome circularizes and stays as an episome in the nucleus
what triggers latent Alphaherpesvirus
Sunburn, systemic infection, immune impairment, stresss
What immune response is used to fight Alphaherpesvirus
Cell mediated immune response required
can people who cant produce antibodies handle herpesvirus infections
YEs
what detects Alphaherpesvirus
T lymphocytes detect antigens presented by MHC I or II proteins