Flashcards in Hodgkin Lymphoma Deck (13):
A neoplastic proliferation of Reed-Sternberg cells?
What are Reed-Sternberg cells?
Large B cells with multilobed nuclei and prominent nucleoli (owl-eyed nuclei)
What are Reed-Sternberg cells classically positive for?
CD15 and CD30
What are the ‘B’ symptoms associated with Hodgkins lymphoma caused by the release of cytokines from the Reed-Sternberg cells?
What cells are attracted by the cytokines released by the Reed-Sternberg cells that make up the bulk of the mass and may lead to fibrosis?
What are the 4 subtypes of tumors, caused by reactive inflammatory cells, used to classify Hodgkin lymphoma?
What is the most common subtype of Hodgkin lymphoma?
What is the classic presentation of nodular sclerosis Hodgkin Lymphoma?
Enlarging cervical or mediastinal lymph node in a young, female adult
What is the typical appearance of nodular sclerosis Hodgkin lymphoma seen on microscopy?
Lymph nodes that are divided by sclerotic bands with Reed-Sternberg cells in the center of the bands
Which subtype of Hodgkin lymphoma has the best prognosis?
What cells are associated with mixed cellularity Hodgkin lymphoma?
What do the Reed-Sternberg cells seen in mixed cellularity Hodgkin lymphoma produce?