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Flashcards in Hodgkin Lymphoma Deck (13):
1

A neoplastic proliferation of Reed-Sternberg cells?

Hodgkin Lymphoma

2

What are Reed-Sternberg cells?

Large B cells with multilobed nuclei and prominent nucleoli (owl-eyed nuclei)

3

What are Reed-Sternberg cells classically positive for?

CD15 and CD30

4

What are the ‘B’ symptoms associated with Hodgkins lymphoma caused by the release of cytokines from the Reed-Sternberg cells?

Fever
Chills
Weight loss
Night Sweats

5

What cells are attracted by the cytokines released by the Reed-Sternberg cells that make up the bulk of the mass and may lead to fibrosis?

Lymphocytes
Plasma cells
Macrophages
Eosinophils

6

What are the 4 subtypes of tumors, caused by reactive inflammatory cells, used to classify Hodgkin lymphoma?

Nodular sclerosis
Lymphocyte-rich
Mixed cellularity
Lymphocyte-depleted

7

What is the most common subtype of Hodgkin lymphoma?

Nodular sclerosis

8

What is the classic presentation of nodular sclerosis Hodgkin Lymphoma?

Enlarging cervical or mediastinal lymph node in a young, female adult

9

What is the typical appearance of nodular sclerosis Hodgkin lymphoma seen on microscopy?

Lymph nodes that are divided by sclerotic bands with Reed-Sternberg cells in the center of the bands

10

Which subtype of Hodgkin lymphoma has the best prognosis?

Lymphocyte-rich

11

What cells are associated with mixed cellularity Hodgkin lymphoma?

Eosinophils

12

What do the Reed-Sternberg cells seen in mixed cellularity Hodgkin lymphoma produce?

IL-5

13

Which subtype of Hodgkin lymphoma is the most aggressive and usually presents in the elderly or HIV positive patients?

Lymphocyte-depleted