Flashcards in Plasma Cell Disorders (Dyscrasias) Deck (14):
A malignant proliferation of plasma cells in the bone marrow?
What may be elevated within the serum of a patient with multiple myeloma, which will stimulate plasma cell growth and immunoglobulin production?
What causes the bone pain with hypercalcemia seen with multiple myeloma?
The neoplastic plasma cells cause activation of the RANK receptor on osteoclasts, which leads to increased osteoclast activity and bone destruction.
What is produced by the plasma cells in multiple myeloma that causes an elevation in serum proteins?
Production of immunoglobulin—most commonly IgG and IgA
What is present on a serum protein electrophoresis demonstrating an increased production of immunoglobulin with respect to multiple myeloma?
An M Spike
What is found on a blood smear of a patient with multiple myeloma?
Rouleaux formation of RBCs
What causes the Rouleaux formation observed in patients with multiple myeloma?
The increase in serum proteins seen with multiple myeloma will cause a decrease in charge between the RBCs causing them to aggregate and form the Rouleaux.
Light chain overproduction by neoplastic plasma cells in the context of multiple myeloma can cause what to occur?
Primary AL amyloidosis
Bence Jones protein in urine
Protein deposition in kidneys can lead to kidney failure
An increased serum protein with an isolated M spike on SPEP is indicative of what disease?
Monoclonal gammopathy of undetermined significance (MGUS)
All other features of multiple myeloma are absent—no lytic bone lesions, hypercalcemia, AL amyloid, or Bence Jones proteinuria
A B-cell lymphoma with monoclonal IgM production?
What are the clinical features of Waldenstrom Macroglobulinemia?
Increased serum protein with M spike (comprised of IgM
Visual and neurologic deficits
What serum protein causes the M spike on SPEP in Waldenstrom Macroglobulinemia?
Why are visual and neurologic deficits seen with Waldenstrom Macroglobulinemia?
IgM is a large pentamer, which causes serum hyperviscosity