Epithelial tumors Flashcards Preview

2nd U2 Path > Epithelial tumors > Flashcards

Flashcards in Epithelial tumors Deck (18):
1

A 72 year old patient presents with a raised, discolored plaque on her arms, legs and face. The lesion has a stuck on appearance and represents a benign squamous proliferation. What is the most likely diagnosis for this patient?

Seborrheic Keratosis

2

What is the characteristic finding seen on histology with seborrheic keratosis?

Keratin pseudocytes

3

A patient presents with a sudden onset of multiple seborrheic keratoses? What is this phenomenon called and what does it suggest?

Leser-Trelat sign

Suggests underlying carcinoma of the GI tract

4

Epidermal hyperplasia with darkening of the skin that usually involves the axilla or the groin…

Acanthosis nigricans

5

What are the 2 abnormalities associated with acanthosis nigricans?

Insulin resistance
Malignancy—especially gastric carcinoma

6

A malignant proliferation of the basal cells of the epidermis…

Basal cell carcinoma

7

What are the 3 common risk factors for the development of basal cell carcinoma?

Prolonged exposure to sunlight
Albinism
Xeroderma pigmentosum

8

What is the presentation of basal cell carcinoma?

Elevated nodule with a central, ulcerated crater that is surrounded by dilated vessels (telangiectatic)

9

Where is the classic location of basal cell carcinoma?

Upper lip

10

What is seen on histology of basal cell carcinoma?

Nodules of basal cells with peripheral palisading

11

What is the treatment for basal cell carcinoma?

Surgical excision

12

A malignant proliferation of squamous cells that is characterized by the formation of keratin pearls…

Squamous cell carcinoma

13

What are the most common risk factors contributing to the development of squamous cell carcinoma?

Prolonged exposure to sunlight
Albinism
Xeroderma pigmentosum
Immunosuppressive therapy
Arsenic exposure
Chronic inflammation

14

Where is the classic site for squamous cell carcinoma development?

Lower lip

15

What is the treatment for squamous cell carcinoma?

Excision of mass

16

What is a precursor lesion for squamous cell carcinoma?

Actinic keratosis

17

How does actinic keratosis present?

As a hypekeratotic, scaly plaque, on the face, back or neck

18

A well-differentiated squamous cell carcinoma that will develop rapidly and then regress spontaneously. The mass presents as a cup-shaped tumor that is filled with keratin debris…

Keratoacanthoma