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Flashcards in Lymphoma Deck (39):
1

A neoplastic proliferation of lymphoid cells that forms a mass…

Lymphoma

2

What are the 2 types of lymphoma?

Non-Hodgkin Lymphoma (60%)

Hodgkin Lymphoma (40%)

3

What characteristics are used to classify difference types of non-Hodgkin Lymphoma?

Cell type (B or T)
Cell size
Pattern of cell growth
Expression of surface markers
Cytogenetic translocations

4

What are the non-Hodgkin lymphomas composed of small B cells?

Follicular lymphoma
Mantle cells lymphoma
Marginal zone lymphoma
Small lymphocytic lymphoma

5

Name the non-Hodgkin lymphoma composed of intermediate-sized B-cells…

Burkitt lymphoma

6

Name the non-Hodgkin lymphoma composed of large B cells…

Diffuse large B-cell lymphoma

7

What are the malignant cells seen in non-Hodgkin Lymphoma?

Lymphoid cells

8

What are the malignant cells seen in Hodgkin lymphoma?

Reed-Sternberg cells

9

What cells make op the mass seen with non-Hodgkin Lymphoma?

Lymphoid cells

10

What cells make up the mass seen with Hodgkin lymphoma?

Reactive cells—inflammatory cells and fibrosis

11

Does Non-Hodgkin or Hodgkin lymphoma present as a painless lymphadenopathy in late adulthood?

Non-Hodgkin lymphoma

12

Does Non-Hodgkin or Hodgkin lymphoma present as a painless lymphadenopathy in young adulthood?

Hodgkin lymphoma

13

A neoplastic proliferation of small B cells that form follicle-like nodules?

Follicular lymphoma

14

What mutation drives follicular lymphoma?

14;18 translocation

15

What genes are translocated causing follicular lymphoma?

BCL2 on chromosome 18
Ig heavy chain locus on 14

16

What is the result of the 14;18 translocation seen in follicular lymphoma?

Overexpression of BCL2—inhibiting apoptosis, especially within the follicular region

17

What is used for the treatment of follicular lymphoma?

Treatment begins when patients have symptoms with low-dose chemotherapy or rituximab, an anti-CD20 antibody

18

What can follicular lymphoma progress into, presenting as an enlarging lymph node?

Diffuse large B-cell lymphoma

19

What are the 4 distinct characteristics of follicular lymphoma differentiated it from reactive follicular hyperplasia?

Disruption of normal lymph node architecture
Lack of tangible body macrophages in germinal centers
BCL2 expression in follicles
Monoclonality

20

A neoplastic expansion of the region immediately adjacent to the follicular region of a lymph node?

Mantle cell lymphoma

21

What is the driver mutation seen with mantle cell lymphoma?

11;14 translocation

22

What genes are translocated with the t(11;14) translocation seen with mantle cell lymphoma?

Cyclin D1 gene from chromosome 11 translocates to Ig heavy chain locus on chromosome 14

23

What does the overexpression of Cyclin D1 promote, which causes mantle cell lymphoma?

G1→S transition within the cell cycle, causing neoplastic proliferation

24

What is marginal zone lymphoma?

Neoplastic proliferation of small B-cells expanding the marginal zone within a lymph node

25

Hashimoto thyroiditis, Sjogren syndrome and H pylori gastritis are all seen in association with marginal zone lymphoma. What do these diseases have in common that causes the marginal zone lymphoma?

Chronic inflammatory state

26

What forms the marginal zone of a lymph node?

Post-germinal center B cells

27

What is MALToma?

Marginal zone lymphoma that is within mucosal sites

28

A neoplastic proliferation of intermediate-sized B cells?

Burkitt Lymphoma

29

What virus is associated with Burkitt lymphoma?

EBV

30

What lymphoma classically presents as an extranodal mass in a child or young adult?

Burkitt lymphoma

31

What are the two forms of Burkitt lymphoma?

African form
Sporadic form

32

The African form of Burkitt lymphoma typically involves the ______.

Jaw

33

The sporadic form of Burkitt lymphoma typically involves the ______.

Abdomen

34

What translocation drives the development of Burkitt lymphoma?

T(8:14)

35

What genes translocate with Burkitt lymphoma?

c-myc on chromosome 8 translocates with Ig heavy chain locus on chromosome 14

36

What does the overexpression of c-myc promote, which causes the development of Burkitt lymphoma?

Cell growth—c-myc is an oncogene

37

What are the characteristic findings seen on microscopy with Burkitt lymphoma?

High mitotic index
Starry-sky appearance

38

What is the most common form of non-Hodgkin lymphoma that involves the neoplastic proliferation of large B cells that grow in sheets?

Diffuse large B-cell lymphoma

39

What are the two causes of diffuse large B-cell lymphoma?

Sporadic
Transformation of a low-grade lymphoma, such a follicular lymphoma