Inflammatory Dermatoses Flashcards Preview

2nd U2 Path > Inflammatory Dermatoses > Flashcards

Flashcards in Inflammatory Dermatoses Deck (21):
1

A pruritic, erythematous, oozing rash with vesicles and edema that commonly involves the face and flexor surfaces…

Atopic Dermatitis

2

What type of reaction causes atopic dermatitis?

Type I hypersensitivity reaction

3

What 2 disorders are associated with atopic dermatitis?

Asthma
Allergic rhinitis

4

A pruritic, erythematous, oozing rash with vesicles and edema that occurs upon exposure to an allergen…

Contact dermatitis

5

What are 3 broad categories of allergens that can cause contact dermatitis?

Poison ivy and nickel jewelry—type IV hypersensitivity
Irritant chemicals—detergents
Drugs—penicillin

6

What is the treatment for contact dermatitis?

Removal of offending agent and topical glucocorticoids

7

What are the three skin abnormalities found with acne vulgaris?

Comedones (whiteheads and blackheads)
Pustules (pimples)
Nodules

8

What is the cause of acne vulgaris?

Chronic inflammation of hair follicles and the associated sebaceous glands

9

What is the mechanism for the formation of comedones seen with acne vulgaris?

Hormone-associated increase in sebum production and excess keratin production causing blocking of the follicles and cause the formation of comedones

10

What is the mechanism for the formation of pustule and nodule formation seen with acne vulgaris?

Propionibacterium acnes infection→ produces lipases causing breakdown of sebum→ release of proinflammatory fatty acids causing pustule and nodule formation

11

What are the treatment options for acne vulgaris?

Benzoyl peroxide—antimicrobial
Vitamin A derivatives—reduction of keratin production

12

A patient presents with well-circumscribed lesions on the extensor surfaces of his arms and legs and on his scalp. Ther is an association with HLA-C and the patient reports that the lesions become worse with localized trauma. The lesions are salmon-colored plaques with a silvery scale. What is the most likely diagnosis?

Psoriasis

13

Psoriasis is caused by excess proliferation of _______.

Keratinocytes

14

What are the 4 major aspects of psoriasis seen on histology?

Acanthosis
Parakeratosis
Collections of neutrophils in the stratum corneum
Thinning of the epidermis above elongated dermal papillae

15

What is acanthosis seen with psoriasis?

Epidermal hyperplasia

16

What is parakeratosis seen with psoriasis?

Hyperkeratosis with retention of keratinocyte nuclei in the stratum corneum

17

With respect to psoriasis, where do neutrophils collect within the epidermis?

Stratum corneum

18

What is Auspitz sign seen with psoriasis?

Thinning of the epidermis above elongated dermal papillae→bleeding when scale is picked off

19

What are the treatment options for psoriasis?

Corticosteroids
UV light with psoralen
Immune-modulating therapy

20

A patient presents with pruritic, planar, polygonal, purple papule lesions on her wrists, elbows, and oral mucosa. The lesions are characterized by reticular white lines on the surface (Wickham striae). Upon microscopy inflammation of the dermal-epidermal junction is visualized with a saw-tooth appearance. What is the most likely diagnosis in this patient?

Lichen Planus

21

What infection is associated with Lichen Planus?

Chronic hepatitis C virus infection