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Flashcards in Normocytic anemia Deck (19):
1

An anemia with normal sized RBCs (80-100 um3 MCV)…

Normocytic anemia

2

What are the 2 causes of normocytic anemia?

Increased peripheral destruction or underproduction

3

Found on blood smear as larger cells with bluish cytoplasm that allow a distinguish between increased peripheral destruction or underproduction of RBCs seen with normocytic anemia…

Reticulocytes

4

What is the normal reticulocyte count?

1-2%

5

Why is reticulocyte count falsely elevated in anemia?

RC is measured as % of total RBCs—so decreased total RBCs is going to falsely increase % of reticulocytes

6

How is reticulocyte count corrected with anemia?

By multiplying reticulocyte count by HCT/45

7

A corrected RC >3% is an indication of what?

A good marrow response –suggesting peripheral destruction

8

A corrected RC

A poor marrow response—suggesting underproduction

9

What are the two types of hemolysis (peripheral RBC destruction)?

Extravascular
Intravascular

10

Hemolysis that involves the destruction of RBCs by the reticuloendothelial system (macrophages of spleen, liver, and lymph nodes)?

Extravascular

11

What is globin broken down into?

Amino acids

12

What two products is heme broken down into?

Iron
Protoporphyrin

13

What is protoporphyrin broken down into?

Unconjugated bilirubin

14

What carries unconjugated bilirubin to the liver to become conjugated and excreted into the bile?

Albumin

15

What are the clinical and laboratory findings seen with extravascular hemolysis?

Anemia with splenomegaly
Jaundice—unconjugated bilirubin
Increased risk of gallstones
Marrow hyperplasia

16

Patients with extravascular hemolysis are at an increased risk of _______.

Gallstones

17

Hemolysis involving destruction of RBCs within vessels…

Intravascular hemolysis

18

What are the 4 major clinical/laboratory findings seen with intravascular hemolysis?

Hemoglobinemia
Hemoglobinuria
Hemosiderinuria
Decreased serum haptoglobin

19

What occurs to serum haptoglobin with intravascular hemolysis?

Decreases