Flashcards in Normocytic anemia Deck (19):
An anemia with normal sized RBCs (80-100 um3 MCV)…
What are the 2 causes of normocytic anemia?
Increased peripheral destruction or underproduction
Found on blood smear as larger cells with bluish cytoplasm that allow a distinguish between increased peripheral destruction or underproduction of RBCs seen with normocytic anemia…
What is the normal reticulocyte count?
Why is reticulocyte count falsely elevated in anemia?
RC is measured as % of total RBCs—so decreased total RBCs is going to falsely increase % of reticulocytes
How is reticulocyte count corrected with anemia?
By multiplying reticulocyte count by HCT/45
A corrected RC >3% is an indication of what?
A good marrow response –suggesting peripheral destruction
A corrected RC
A poor marrow response—suggesting underproduction
What are the two types of hemolysis (peripheral RBC destruction)?
Hemolysis that involves the destruction of RBCs by the reticuloendothelial system (macrophages of spleen, liver, and lymph nodes)?
What is globin broken down into?
What two products is heme broken down into?
What is protoporphyrin broken down into?
What carries unconjugated bilirubin to the liver to become conjugated and excreted into the bile?
What are the clinical and laboratory findings seen with extravascular hemolysis?
Anemia with splenomegaly
Increased risk of gallstones
Patients with extravascular hemolysis are at an increased risk of _______.
Hemolysis involving destruction of RBCs within vessels…
What are the 4 major clinical/laboratory findings seen with intravascular hemolysis?
Decreased serum haptoglobin