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Flashcards in Hodgkin's Disease Deck (40)
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1

What is Hodgkin's disease?

A malignancy of unknown etiology usually arising in the lymph nodes

2

is hodgkin's disease curable

very curable

3

What cell is associated with HD

Reed- Sternberg cell

4

When was HD discovered?

1832 Thomas Hodgkin
-discovered in dead people

5

Who is the disease most prevalent in?

common in young people

6

Incidence rates:
biomodal age distribution

first peak 15-34
second @ 50

7

Incidence rate:
2002

7000 new cases, 3700 male, 3300 female
1400 deaths, 800 male, 600 female

8

incidence rate:
2007

8190 new, 4470 male, 3720 female
1070 deaths, 770 male, 300 female

9

incidence rate:
2017

8260 new, 4650 male, 3610
1070 deaths, 630 male, 440 female

10

9x increase in ____ sex sibs

same

11

5x increase in ____ sex sibs

opposite

12

3x increase with _____ degree relation

first

13

subcategories of Hodgkin's Disease

Classic Hodgkin Lymphoma (CHL)
LRHL
MCHL
NSHL
LDHL
Nodular Lymphocyte predominant Hodgkin Lymphoma
NLPHL

14

LRHL

-early stages
-5% of all hodgkins cases
-stage 1/ stage 2
-Infrequent systemic sym (10%)
-more common in males
-upper body

15

MCHL

-mix of all types
--lymphocytes, epithelial histocytes, neutrofills, plasma (inflammatory)
- more common in older folks (38)
-Associated with HIV
-in males
-abdomen and spleen

16

NSHL

-75% of all hodgkin's cases
-20's and 30's, 50-55
-equal distribution b/w males and females
-neck or chest
**** MOST COMMON

17

NLPHL

-5% of Hodgkin's cases
-asymptomatic young men
-cervical, axillary & inguinal LN
-30-55 years
-early stages
-- longer survival times
-variant of reed-stern cell. Referred to as popcorn cell because of look

18

CHL

-95% diagnosed
-main characteristic is the reed- stern cell
-B symptomatic: fever, night sweats, weight loss

19

LDHL

-rarest of the 4
-common in men
-30's- those with HIV
-worst prognosis
--advanced disease (b symptoms)
-abdomen adenopathy
-spleen, liver, bone marrow

20

What staging system does Hodgkin's use?

Ann Arbor and costwold
* higher stage=bad prognosis

21

Signs and symptoms

-cervical, supraclavicular, mediastinal LN, splenomegaly
-B symptoms (40%)
-elevated sedimentation rate and elevated alkaline phosphatase

22

paritis

severe itching

23

malaise

just don't feel good

24

erythmatis rash

reddening of skin

25

most common above diaphragm

80%

26

how much below diaphragm?

about 10%

27

elevated sedementation rate

how fast blood count falls to bottom of test tube

28

How do they diagnose Hodgkin's disease

history and physical
X-rays (CT and PET)
labs
biopsy of lung LN (enlarged)
Stages (1B, 2B, 3, 4)

29

Clinical features of Hodgkins Disease

painless lymphadenopathy
fever
night sweats
weight loss
pruitus
alcohol-induced pain

30

Non- Hodgkin's Lymphoma

generalized painless lymphadenopathy
vague abdominal discomfort
back pain
gastrointestinal complaints