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Flashcards in I - Cell Biology Deck (92):
1

Command center of the cell

nucleus

2

The outer nuclear membrane is continuous with

endoplasmic reticulum

3

Most abundant form of chromatin

euchromatin

4

Site of DNA Transcription

nucleus

5

Responsible for ribosomal RNA synthesis

nucleolus

6

Transcriptionally inactive chromatin

heterochromatin

7

Complex of DNA, histone and non-histone proteins

chromatin

8

Barr Bodies are _____chromatin.

heterochromatin

9

Allows passage of nuclear substances to the cytoplasm

nuclear pore

10

Nucleolus: Maturing Ribosomes

pars granulosa

11

Nucleolus: Active Zone

pars fibrosa (dense fibrillar zone)

12

Nucleolus: Inactive DNA

fibrillar center

13

The nucleus is the site of DNA replication and transcription of DNA in

precursors of RNA molecules

14

Contains all enzymes required for replication and repair of newly synthesized DNA

Nucleus

15

Double stranded helical molecule that carries genetic information of the cell

DNA

16

Histone proteins are _____ charged.

positive

17

Important in forming the nucleosome and solenoid fibers in chromatin

histones

18

Basic repeating unit of the chromatin fiber

nucleosome

19

Non-histone proteins contain enzymes involved in

nuclear functions

20

Chromatin: condensed, dark, inactive, Barr bodies

heterochromatin

21

Chromatin: dispersed, light, actively transcribed

euchromatin

22

Organelles: contains their own set of DNA

mitochondria

23

Site of post-translational modification

golgi apparatus

24

Sequestration and release of Ca in striated muscle

sarcoplasmic reticulum

25

Organelles: contains large and small subunits

ribosomes

26

Organelles: synthesis of steroid hormones, phospholipids and TG

smooth endoplasmic reticulum

27

Organelles: protein sorting and packaging

golgi apparatus

28

Organelles: synthesis of secretory proteins, membrane bound and lysosomal enzymes

rough endoplasmic reticulum

29

Organelles: production of CoA, TCA, beta-oxidation, oxidative phosphorylation

mitochondria

30

Organelles: contains inner and outer membranes

mitochondria

31

Organelles: ATP synthesis

mitchondria

32

Organelles: ER without ribosomes

smooth endoplasmic reticulum

33

Organelles: synthesis of membrane phospholipids

smooth endoplasmic reticulum

34

Organelles: synthesis of steroid hormones

smooth endoplasmic reticulum

35

Organelles: drug detoxification

smooth endoplasmic reticulum

36

Organelles: fatty acid elongation

smooth endoplasmic reticulum

37

Organelles: calcium fluxes associated with muscle contraction

smooth endoplasmic reticulum

38

Organelles: contains ribosomes on its cytoplasmic surface

rough endoplasmic reticulum

39

Organelles: Synthesis of secretory proteins, membrane proteins and lysosomal enzymes

rough endoplasmic reticulum

40

Organelles: co-translational modification of proteins

rough endoplasmic reticulum

41

Organelles: stacks of membranous cisternae with cis and trans face

golgi apparatus

42

Organelles: post-translational modification

golgi apparatus

43

Organelles: protein sorting and packaging

golgi apparatus

44

Organelles: non-membrane bound vesicles where mRNA is translated into an AA sequence

free ribosomes

45

Organelles: site of cytosolic and organellar protein synthesis

free ribosomes

46

Mitochondrial genome defect with muscle weakness/pain, seizures, hemiparesis, dementia

MELAS - Mitochondrial Encephalopathy, Lactic Acidosis & Stroke-like symptoms

47

Organelles: drug detoxification

SER

48

Organelles: abundant in ovaries, testes and adrenals

SER

49

Organelles: abundant in neurons

RER

50

Organelles: abundant in pancreas and thyroid

RER

51

Organelles: abundant in red muscle fibers

mitochondria

52

Organelles: synthesis of secretory proteins, membrane proteins and lysosomal enzymes

RER

53

Organelles: membrane cycling

golgi apparatus

54

Membrane-Bound Vesicles: cell garbage and disposal system

lysosome

55

Membrane-Bound Vesicles: contains oxidative enzyme, synthesis of hydrogen peroxide

peroxisome

56

Membrane-Bound Vesicles: contains hydrolytic enzymes

lysosome

57

Membrane-Bound Vesicles: beta-oxidation of long-chain FA

peroxisome

58

Suicide Bags

lysosome

59

Major Enzyme in Peroxisomes

catalase

60

Membrane-Bound Vesicles: bile acid synthesis

peroxisome

61

Major Protein in Lysosome

acid hydrolase

62

Membrane-Bound Vesicles: enzymes produced in free ribosomes

peroxisome

63

Membrane-Bound Vesicles: enzymes produced in RER

lysosome

64

Glycogen storage disease involving a defect in lysosomal metabolism, acid maltase deficiency, muscle weakness, cardiorespiratory failure

Pompe Disease

65

Cytoskeleton: actin

microfilament

66

Cytoskeleton: mechanical support for cells

microfilament

67

Cytoskeleton: muscle contraction

microfilament (with myosin)

68

Cytoskeleton: exocytosis, endocytosis, cytokinesis, structural proteins

microfilament

69

Cytoskeleton: microvilli

microfilament

70

Cytoskeleton: tumor markers

intermediate filament

71

Cytoskeleton: link between the extracellular matrix, cytoplasm and nucleus

intermediate filament

72

Cytoskeleton: α & β tubulin

microtubule

73

Cytoskeleton: intracellular vesicle and organelle transport

microtubule

74

Cytoskeleton: mitosis and meiosis (centrioles)

microtubule

75

Cytoskeleton: ciliary and flagellar movement

microtubule

76

Cytoskeleton: demonstrates tissue specificity, pathologic markers

intermediate filament

77

Cytoskeleton: thinnest

microfilament

78

Cytoskeleton: inhibited by Amanita mushroom toxin

microfilament

79

Cytoskeleton: Chediak-Higashi Syndrome

microtubule

80

Intermediate Filament Tumor Markers: epithelial cells (squamous cell CA, adenoCA)

cytokeratin

81

Intermediate Filament Tumor Markers: endothelial cells, vascular smooth muscle, fibroblast, chondroblast

vimentin

82

Intermediate Filament Tumor Markers: skeletal and smooth muscle

desmin

83

Intermediate Filament Tumor Markers: neurons

neurofilament

84

Intermediate Filament Tumor Markers: glial cells

glial fibrillar acidic protein

85

Intermediate Filament Tumor Markers: inner membrane of nuclear envelope

laminins A, B & C

86

Microtubule-Associated Proteins: ATPase activity for the movement of vesicles towards te axon terminal, anterograde transport

kinesin

87

Microtubule-Associated Proteins: ATPase activity toward the minus end (cell body)

dynein

88

Microtubule-Associated Proteins: ATPase activity for elongation of nerve axons

dynamin

89

Drug that acts on microtubules of fungal cells

Griseofulvin

90

Anti-inflammatory drug that acts on microtubules

Colchicine

91

Anti-cancer drugs that act on microtubules

Vinblastine, Vincristine, Taxanes

92

Microtubule polymerization defect, decreased ability for phagocytosis, recurrent pyogenic infections, partial albinism, peripheral neuropathy

Chediak-Higashi Syndrome