V - Blood Flashcards Preview

Histology > V - Blood > Flashcards

Flashcards in V - Blood Deck (77)
1

Blood: no nucleus/mitochondria, anaerobic glycolysis

erythrocytes

2

Protein that maintains the biconcave shape of the RBC

spectrin

3

Life span of adult RBCs

120 days

4

Life span of fetal RBCs

90 days

5

Life span of reticulocytes

1-2 days

6

Point mutation in the gene for the beta hemoglobin chain in RBCs

Sickle Cell Anemia

7

Multilobulated nucleus (2-5 lobes) connected by thin strand of nuclear materials (chromatin) with light staining very fine granules, phagocytic

neutrophils

8

Most abundant type of leukocyte (70%)

neutrophils

9

Has small golgi apparatus, sparse mitochondria and ribosomes, absent RER

neutrophils

10

Lifespan of neutrophils

1-4 days, half-life of 6-8 hours in blood

11

Hereditary immune system disorder that affects neutrophils

Chronic Granulomatous Disease

12

Shows the average level of blood glucose over the past 3 months

HbA1c

13

Bilobulated nucleus with numerous pink-orange granules, 1-3% of leukocytes

eosinophils

14

Highly involved in immune response against parasites especially helminths

eosinophils

15

Granulocyte that controls mechanisms in anaphylaxis and asthma

eosinophils

16

Allergic inflammatory condition of the esophagus that presents as heartburn and food impaction

Eosinphilic Esophagitis

17

Least common leukocyte (0.01-0.3%)

basophils

18

Contains large cytoplasmic granules which obscure the nucleus under light microscopy

basophils

19

Granulocyte that is important in immediate hypersensitivity reactions (type I) and anaphylaxis

basophils

20

Releases histamine, proteoglycans (heparin, chondroitin) and proteolytic enzymes (elastase, lysophospholipase)

basophils

21

Basophils in tissues

mast cells

22

Hematologic indicator of lead poisoning

basophilic stippling

23

Smallest leukocytes

lymphocytes

24

3 Main Types of Lymphocytes

T-cell, B-cell, Natural Killer Cells

25

Lymphocytes involved in cell-mediated immunity

T-cells

26

Lymphocytes responsible for humoral immunity

B-cells

27

Recognize non-self antigens during antigen presentation

T-cells and B-cells

28

Defends the host from tumors and virus infected cells

Natural Killer Cells

29

Natural Killer cells distinguish infected and cancerous cells from normal cells by recognizing changes in a surface molecule

MHC (major histocompatibility complex) Class I

30

Lymphocytes: lysis of virally infected cells and tumor cells

NK cells

31

Lymphocytes: release cytokines and growth factors that regulate other immune cells

helper T-cells (CD4)

32

Lymphocytes: lysis of virally infected cells, tumor cells and allografts

cytotoxic T-cells (CD8)

33

Lymphocytes: secretion of antibodies

B-cells

34

Large lobulated C-shaped nucleus, replenish resident macrophages under normal states

monocytes

35

Can move quickly (8-12h) in response to inflammation to sites of infection in the tissues and divide/differentiate into macrophages and dendritic cells to elicit an immune response, phagocytosis

monocytes

36

Macrophage: primary alveolus of the lungs

dust cells (alveolar macrophage)

37

Macrophage: connective tissue

histiocytes

38

Macrophage: liver

Kuppfer cells

39

Macrophage: neural tissue

microglia

40

Macrophage: granulomas

epithelioid

41

Macrophage: bone

osteoclast

42

Macrophage: spleen

sinusoidal cells

43

Macrophage: skin

Langerhan's cells

44

Fragments of megakaryocytes, non-nucleated

platelets (thrombocytes)

45

Lifespan of platelets

10 days

46

Involved in hemostasis leading to the formation of blood clots, releases srotonin which causes vasoconstriction

platelets

47

Abnormality of platelets in which they lack glycoprotein IIb/IIIa

Glanzmann's thrombasthenia

48

Warfarin: PT

prolonged

49

Warfarin: PTT

prolonged

50

Warfarin: Bleeding Time

normal

51

Warfarin: Platelet Count

normal

52

DIC: PT

prolonged

53

DIC: PTT

prolonged

54

DIC: Bleeding Time

prolonged

55

DIC: Platelet Count

decreased

56

Aspirin: PT

normal

57

Aspirin: PTT

normal

58

Aspirin: Bleeding Time

prolonged

59

Aspirin: Platelet Count

normal

60

Glanzmann's thrombasthenia: PT

normal

61

Glanzmann's thrombasthenia: PTT

normal

62

Glanzmann's thrombasthenia: Bleeding Time

prolonged

63

Glanzmann's thrombasthenia: Platelet Count

normal

64

Bernard-Soulier syndrome: PT

normal

65

Bernard-Soulier syndrome: PTT

normal

66

Bernard-Soulier syndrome: Bleeding Time

prolonged

67

Bernard-Soulier syndrome: Platelet Count

decreased

68

Granulocytes: life span of 1-4 days

neutrophils

69

Granulocytes: life span of 1-2 weeks

eosinophils

70

Granulocytes: life span of several months

basophils

71

Granulocytes: kill and phagocytose bacteria

neutrophils

72

Granulocytes: kill helminths and other parasites, modulate local inflammation

eosinophils

73

Granulocytes: modulate inflammation, release histamine during allergies

basophils

74

Agranulocytes: life span of hours to many years

lymphocytes

75

Agranulocytes: life span of hours to years

monocytes

76

Agranulocytes: effector and regulatory cells for adaptive immunity

lymphocytes

77

Agranulocytes: precursors of macrophages and other mononuclear phagocytic cells

monocytes