X - Immune System and Lymphoid Organs Flashcards Preview

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Flashcards in X - Immune System and Lymphoid Organs Deck (72)
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1

Immediate, nonspecific actions that prevent infections or penetration of the host body

Innate Immunity

2

Immunity: skin, mucous membranes, neutrophils, leukocytes, NK cells

Innate Immunity

3

Immunity: HCl, organic acids, defensins, lysozyme, complement, interferons

Innate Immunity

4

Immunity: acquired gradually by exposure to microorganisms, more specific, slower, B and T cells, antigen presenting cells, memory lymphocytes

Adaptive Immunity

5

Immunity: involved in both innate and adaptive, coordinate cell activities in the immune response

cytokines

6

Cytokines: growth and differentiation factors for leukocyte progenitor cells in bone marrow

GM-CSF, M-CSF

7

Cytokines: stimulation of inflammation and fever

TNF-α, TGF-β, IL-1

8

Cytokines: stimulation of growth in T lymphocytes and NK cells

IL-12

9

Cytokines: growth factors for T helper cells and B lymphocytes

IL-2, IL-4

10

Cytokines: eosinophil proliferation, differentiation and activation

IL-5

11

Cytokines: activation of macrophages

Interferon-γ, IL-4

12

Cytokines: inhibition of macrophages and specific adaptive immune responses

IL-10

13

Cytokines: antiviral activity

Interferon-α, Interferon-β

14

Cytokines: chemokine for neutrophils and T lymphocytes

IL-8

15

Large Y-shaped protein produced by B-cells that is used by the immune system to identify and neutralize foreign objects such as bacteria and viruses

antibodies

16

Recognizes a unique part of the foreign target called an antigen

antibodies

17

Each tip of the "Y" of the antibody contains a _____ (lock) that is specific for an _____ (key).

paratope, epitope

18

Antibodies are produced by

plasma cells

19

Immunoglobulins by Amount

G (75-85%), A (10-15%), M (5-10%), E (0.002%), D (0.001%)

20

Immunoglobulins: secretory IG, mucosal areas, gut, respiratory tract, prevents colonization by pathogens, saliva, tears, milk

IgA

21

Immunoglobulins: antigen receptor on B-cells that have not been exposed to antigens, activate basophils and mast cells to produce antimicrobial factors

IgD

22

Immunoglobulins: binds to allergens and triggers histamine release from mast cells and basophils, protects against parasitic worms

IgE

23

Immunoglobulins: provides the majority of antibody-based immunity against invading pathogens, only antibody capable of crossing the placenta to give passive immunity to fetus

IgG

24

Immunoglobulins: expressed on the surface of B-cells (monomer) and in a secreted form (pentamer) with very high avidity, first antibody produced in initial immune response, activates complement

IgM

25

Hypersensitivity: immediate

type I

26

Hypersensitivity: anaphylaxis

type I

27

Hypersensitivity: atopy

type I

28

Hypersensitivity: IgE

type I

29

Hypersensitivity: cytotoxic (antibody-dependent)

type II

30

Hypersensitivity: Goodpasture's Syndrome

type II