Immunosupressants Flashcards Preview

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Flashcards in Immunosupressants Deck (12):
1

Block the differentiation of T-cells by inhibiting cacineurin--> thus preventing the production of IL-2 and its receptor

Cyclosporin

2

Carries a major side effect of nephrotoxicity

Cyclosporin

3

MOA of tacrolimus (FK-506)

Binds to FK-binding protein--> inhibiting calcineurin and secretion of IL-2

4

Sirolimus also known as

rapamycin

5

Inhibits T-cell proliferation in response to IL-2

sirolimus

6

MOA of azathioprine

antimetabolite precursor of 6-MP--> toxic to proliferating lymphocytes

7

Be careful giving this drug with Azathioprine

Allopurinol

8

OKT3 also known as

Muromonab-CD3

9

Muromonab-CD3 MOA

Monoclonal Ab that binds to CD3 (common to all T-cells) and therefore block activation of T-cells

10

Inhibits IMP-dehydrogenase (inositol monophosphate)--> Prevents guanine synthisis

Mycohpneolate

11

What is the major adverse effect of mycophenolate

Carries increased risk for lymphoma

12

CD25 blocker

Daclizumab