DOC for gonorrhea:
What else should always be treated?
Azithromycin or doxycycline for chlamydia
Antiviral that does not need to be activated by enzymes and inhibits both DNA polymerase and DNA-dependant-RNA-polymerase?
Used in HIV/AIDS and in gancyclovir resistant CMV
MOA and indication for donepazil?
Memantine MOA and use?
NMDA receptor antagonist
Lyme disease DOC
Ceftriaxone and doxicycline
DOC for gardnerella vaginalis and trichamonas vaginalis
DOC for giardia
DOC for entomoeba hiatolytica?
idoquinol for asymptomatic cyst passers
MOA of Carbamazepine?
Blacks voltage gated Na channels in the CNS
DOC for patient with aspiration pneumonia?
MOA of Heparins
bind tightly to antithrombin
MOA and use of Colchicine?
Binds to and inhibits polymerization of microtubules
Low potency tyical antipsychotics
(THey're CHill and easy to RID)
Antipsychotic associated with diabetes
Antipsychotic associated with agranulocytosis
Which antipsychotics cause NMS? Tx?
High potency typicals
Dantrolene and Bromocryptine
(e.g. Haloperidol, fluphenazine, loxapine, thiothixine, triflyperazine)
Tx of Toxoplasmosis
Pyrimethamine and sulfadiazine
Which of the anxiolytics has no hypnotic or sedative effects?
What is it's disadvantage?
-->Takes a long time to act (~2 weeks)
Most important toxicity associated with Isoniazid
Prophylaxis for mycobacterium in AIDS pts
Histoplasma prophylaxis in AIDS pts
MOA of fenasteride
normally converts testosterone to DHT
-->induces hair growth
Inhibit dihydropteroin synthase
-->sulfamethoxazole, sulfisoxazole, sulfadiazine
Common use of TMP-SMX
pneumocystis jirovecii (tx and prophylaxis)
inhibits topisomerase II
(Ciprofloxacin, norfloxacin, levofloxacin, ofloxacin)
*do not take with antiacids
Fluroquinolones useful in treatment of
G(-) infections of the urinary and GI
Most important side effect associated with fluroquinolones
cartilage damage and tendon rupture
MOA of metronidazole
Formation of free radicals that damage DNA
Infections treated with metronidazole
GET GAP on the Metro(nidazole)
Pylori (H. pylori)
Important SE of metronidazole
Disulfuram like reaction
What drug is used as prophylaxis in cystic fibrosis? For what infection?
Fluroquinolones (pseudomonas mostly)
Penecillin blocks what enzyme
Infection commonly tx'ed with penicillin
Syphillis (treponema pallidum)
Used to tx S. aureus except MRSA
Oxacillin, nafcillin, dicloxacillin
Ampicillin and amoxicillin
What organisms are commonly Tx'ed with aminopenicillins?
Penicillins with major antipseudomonal activity
Ticacillin and pipercillin
Beta-lactamase inhibitors typically added to penicillins to increase their efficacy
1st gen cephalosporins
What do they Tx
Cefazolin and cephalexin
2nd gen cephalosporins and indications
Cefoxitin, cefaclor, and cefuroxime
3rd cephalosporins and indications
Ceftriaxone (meningitis and gonorrhea) and ceftazidine pseudomonas
4th gen cephalosporins and indication
Tx of UTI in pregnant female
inhibits bacterial ribosomes
Vancomycin MOA and common resistance
D-ala-D-lac is common mutation resulting in VRE and other resistant strains
Buy AT 30 CCEL at 50
Aminoglycosides and tetracyclines inhibit 30s
Chloramphenicol and clindamycin, erythromycin (macrolides) and linezolid inhibit 50s
Aminoglycoside drugs, major SE and major indications
Gentamicin, neomicin, stroptomycin
Inhibit formation of the initiation complex and cause misreading (also block translocation)
-->serious G(-) rod infections
Neprotoxic and ototoxic
What drugs will increase the toxicity of aminoglycosides?
How is doxycycline eliminated? What impact on usage does this have?
Can be used in pts with renal failure
Usage of demeclocycline
ADH antagonist--> Tx of SIADH
Major indications for tetracycline therapy?
Chlamydia and Rickettsia
discoloration of teeth
Used to tx sterptococcal infection in Pts allergic to penicillin
Azithromycin, clarithromycin, erythromycin
Indications for macro-slides?
atypical pneumona--> mycoplasma, chlamydia, legionella
G+ cocci in pts allergic to penicillin
Antimicrobial drug that causes red-green color blindness
What drug should always be given to neonates with suspected meningitis?
Ampicillin to cover listeria
Purine analogue that is highly resistant to degredation by adenosine demainase and is use in the Tx of hair cell leukemia