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Flashcards in MOA and DOC Deck (59):
1

DOC for gonorrhea:

What else should always be treated?

Ceftriaxone

AND

Azithromycin or doxycycline for chlamydia

2

Antiviral that does not need to be activated by enzymes and inhibits both DNA polymerase and DNA-dependant-RNA-polymerase?

Foscarnet

Used in HIV/AIDS and in gancyclovir resistant CMV

3

MOA and indication for donepazil?

Alzheimers

AChEi

4

Memantine MOA and use?

Alheimer's

NMDA receptor antagonist

5

Legionella DOC

Erythromycin (macrolide)

6

Psuedomonas DOC

Aminoglycosides

Neomycin

Gentimycin

Streptomycin

Tobramycin

7

Lyme disease DOC

Ceftriaxone and doxicycline

8

DOC for gardnerella vaginalis and trichamonas vaginalis

Metronidazole

+/- erythromycin

9

DOC for giardia

Metronidazole

10

DOC for entomoeba hiatolytica?

Metronidazole

idoquinol for asymptomatic cyst passers

11

MOA of Carbamazepine?

Blacks voltage gated Na channels in the CNS

12

DOC for patient with aspiration pneumonia?

Clindamycin

13

MOA of Heparins

bind tightly to antithrombin

14

MOA and use of Colchicine?

Binds to and inhibits polymerization of microtubules

Acute gout

15

Low potency tyical antipsychotics

Chlorpromazine

Thioridizine

(THey're CHill and easy to RID)

16

Antipsychotic associated with diabetes

Olanzapine

17

Antipsychotic associated with agranulocytosis

Clozapine

18

Atypical antipsychotics

Olanzepine

Rispiridone

Aripiprazole

Clozapine

Quetiapine

19

Which antipsychotics cause NMS? Tx?

High potency typicals

Dantrolene and Bromocryptine

(e.g. Haloperidol, fluphenazine, loxapine, thiothixine, triflyperazine)

20

Tx of Toxoplasmosis

Pyrimethamine and sulfadiazine

21

Which of the anxiolytics has no hypnotic or sedative effects?

What is it's disadvantage?

Buspirone

-->Takes a long time to act (~2 weeks)

-->No addiction

22

Most important toxicity associated with Isoniazid

Hepatotoxicity

23

Prophylaxis for mycobacterium in AIDS pts

Azithromycin

24

Histoplasma prophylaxis in AIDS pts

Itraconazole

25

MOA of fenasteride

Inhibits 5-alpha-reductase

normally converts testosterone to DHT

-->induces hair growth

26

Inhibit dihydropteroin synthase

Sulfonamides

-->sulfamethoxazole, sulfisoxazole, sulfadiazine

27

Common use of TMP-SMX

UTI

pneumocystis jirovecii (tx and prophylaxis)

Shitgella

Salmonella

 

28

inhibits topisomerase II

Fluroquinolones

(Ciprofloxacin, norfloxacin, levofloxacin, ofloxacin)

*do not take with antiacids

29

Fluroquinolones useful in treatment of

G(-) infections of the urinary and GI

Pseudomondas, neisseria

30

Most important side effect associated with fluroquinolones

cartilage damage and tendon rupture

31

MOA of metronidazole

Formation of free radicals that damage DNA

32

Infections treated with metronidazole

GET GAP on the Metro(nidazole)

Giaridia

Entomoeba histolytica

Trchomonas

Gardernella

Anaerobes

Pylori (H. pylori)

33

Important SE of metronidazole

Disulfuram like reaction

34

What drug is used as prophylaxis in cystic fibrosis? For what infection?

Fluroquinolones (pseudomonas mostly)

35

Penecillin blocks what enzyme

Transpeptidase

36

Infection commonly tx'ed with penicillin

Syphillis (treponema pallidum)

Penicillin G

37

Used to tx S. aureus except MRSA

Oxacillin, nafcillin, dicloxacillin

38

Aminopenicillins

Ampicillin and amoxicillin

39

What organisms are commonly Tx'ed with aminopenicillins?

HELPSS

Haemophilus

E. coli

Listeria

Proteus miribilis

Salmonella

Shigella

40

Penicillins with major antipseudomonal activity

Ticacillin and pipercillin

41

Beta-lactamase inhibitors typically added to penicillins to increase their efficacy

Clvulinic acid

Sulbactam

Tazobactam

42

1st gen cephalosporins

What do they Tx

Cefazolin and cephalexin

PEcK

Proteus

E. coli

Klebsiella

43

2nd gen cephalosporins and indications

Cefoxitin, cefaclor, and cefuroxime

HEN PEcKS

Haemophilus

Enterobacter

Neisseria

Proteus

E. coli

Klebsiella

Serratia

44

3rd cephalosporins and indications

Ceftriaxone (meningitis and gonorrhea) and ceftazidine pseudomonas

 

45

4th gen cephalosporins and indication

Cefipime

Pseudomonas

46

Tx of UTI in pregnant female

Nitrofurantoin

inhibits bacterial ribosomes

47

Vancomycin MOA and common resistance

D-ala-D-ala inhibition

D-ala-D-lac is common mutation resulting in VRE and other resistant strains

48

Buy AT 30 CCEL at 50

Aminoglycosides and tetracyclines inhibit 30s

Chloramphenicol and clindamycin, erythromycin (macrolides) and linezolid inhibit 50s

49

Aminoglycoside drugs, major SE and major indications

Gentamicin, neomicin, stroptomycin

Inhibit formation of the initiation complex and cause misreading (also block translocation)

-->serious G(-) rod infections

Neprotoxic and ototoxic

50

What drugs will increase the toxicity of aminoglycosides?

Loop diuretics

51

How is doxycycline eliminated? What impact on usage does this have?

Fecally (Dukee-cycline)

Can be used in pts with renal failure

52

Usage of demeclocycline

ADH antagonist--> Tx of SIADH

53

Major indications for tetracycline therapy?

Chlamydia and Rickettsia

54

Tetracycline teratogenicity

discoloration of teeth

55

Used to tx sterptococcal infection in Pts allergic to penicillin

Macrolides

Azithromycin, clarithromycin, erythromycin

56

Indications for macro-slides?

atypical pneumona--> mycoplasma, chlamydia, legionella

STD--> chlamydia

G+ cocci in pts allergic to penicillin

57

Antimicrobial drug that causes red-green color blindness

Ethambutol

Optic neuropathy

58

What drug should always be given to neonates with suspected meningitis?

Ampicillin to cover listeria

59

Purine analogue that is highly resistant to degredation by adenosine demainase and is use in the Tx of hair cell leukemia

Cladribine