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Flashcards in Infection Deck (188)
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180

A young patient presents with a large number of persistent bacterial skin abscesses, what primary immunodeficiencies may he have? What tests would you like?

Phagocyte deficiency
T cell deficiency

FBC, lymphocyte subset analysis, adhesion molecule expression, neutrophil function tests, IgG levels

181

What can cause primary immunodeficiencies?

Single gene disorders
Polygenetic disorders
Hla polymorphism

182

What two general categories of secondary immunodeficiency are there? Examples?

Decreased production of immune component
- HIV, splenectomy, liver disease, malnutrition

Increased loss of immune components
- nephropathy, burns, enteropathy

183

What drugs can cause neutropenia?

Pheytoin, alcohol, chemotherapy, immunosuppressants

184

What diseases can cause neutropenia?

HIV, EBV, HBV, vit b deficiency, bone marrow cancer

185

Why might the spleen need removing?

Infarction
Trauma
Immune haemolytic disease
Tumour

186

What disease can cause splenic atrophy?

Coeliac disease

187

What happens after the spleen is removed?

Decreased IgG production
Thus decreased opsinisation
Thus increased risk of encapsulated bacteria (neiserria meningitidis, haemophillus influenzae, strep. pneumoniae