Flashcards in Infection Deck (188)
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180
A young patient presents with a large number of persistent bacterial skin abscesses, what primary immunodeficiencies may he have? What tests would you like?
Phagocyte deficiency
T cell deficiency
FBC, lymphocyte subset analysis, adhesion molecule expression, neutrophil function tests, IgG levels
181
What can cause primary immunodeficiencies?
Single gene disorders
Polygenetic disorders
Hla polymorphism
182
What two general categories of secondary immunodeficiency are there? Examples?
Decreased production of immune component
- HIV, splenectomy, liver disease, malnutrition
Increased loss of immune components
- nephropathy, burns, enteropathy
183
What drugs can cause neutropenia?
Pheytoin, alcohol, chemotherapy, immunosuppressants
184
What diseases can cause neutropenia?
HIV, EBV, HBV, vit b deficiency, bone marrow cancer
185
Why might the spleen need removing?
Infarction
Trauma
Immune haemolytic disease
Tumour
186
What disease can cause splenic atrophy?
Coeliac disease
187
