Inflammatory Bowel Disease Flashcards Preview

Liver + GI > Inflammatory Bowel Disease > Flashcards

Flashcards in Inflammatory Bowel Disease Deck (23):
1

which has a sharp cut-off?

ulcerative colitis

U | C

2

spread of UC

starts at rectum, continuously moves distally

no further than ileocaecal valve

3

which just affects mucosa and has NO granuloma?

UC - continuous and shallow

4

What is Chron's associated with?

altered cell-mediated immunity
smoking increases risk
NSAIDs may exacerbate disease

5

features chron's

deep fissuring ulcers (transmural granulomatous inflammation)
fibrous scarring and cobblestone
narrow lumen, thickened wall

6

location of Chron's

discontinuous
anywhere from mouth to anus

esp. terminal ileum

7

fibrous scarring and cobblestone

narrow lumen, thickened wall

Chron's

8

epidemiology

most common in western
Px usually teens + twenties

9

IBD aetiology

1. genetic susceptibility,
2. the environment
3. host immune response

10

smoking

increases risk for CD
reduced risk for UC

11

host immune response

IBD results from defective mucosal immune system producing an abnormal response to luminal antigens

12

Clinical features CD

depend on region of involved bowel

ileocaecal is the most common

abd pain, weight loss, diarrhoea, fever etc.

13

Clinical features UC

diarrhoea, often bloody and mucus

14

blood tests

anaemia is common

Acute CD: raised ESR, CRP and platelets

15

radiology + imaging

rigid or flexible sigmoidoscopy

rectal biopsy

colonoscopy
SB imaging

16

Tx mild UC

5-ASA e.g.sulfasalazine

17

Tx moderate UC

if 4-6 motions/day but otherwise well, try prednisolone

18

Tx severe UC

>6 months.

admit for NBM & IV hydration

hydrocortisone
rectal steroids

19

Tx for proctitis (inflammation of rectum + anus)

suppositories

20

surgery for UC

proctocolectomy + terminal ileostomy

21

Tx mild attacks in CD

prednisolone

22

what kind of diet for CD?

low residue diets

23

Tx severe attacks in CD

admit for IV steroids, NBM
hydrocortisone
? blood transfusion