Liver general

Question 1

Properties of sinusoids?

Answer 1

leaky + have kuppfer cells

Question 2

What happens from zones 1-3?

Answer 2

they receive progressively less oxygen and blood flow

Question 3

whats in the portal tract?

Answer 3

thick walled hepatic artery
thin-walled portal vein
bile-duct

Question 4

What are the vessels of the portal tract lined with?

Answer 4

cuboidal epithelium

Question 5

what replaces hepatocytes that are lost in chronic liver damage?

Answer 5

collagen

Question 6

name 2 cholestatic liver enzymes

Answer 6

alkaline phosphatase, gamma-GT

Question 7

name 2 hepatocellular liver enzymes

Answer 7

transaminases (AST, ALT)

Question 8

in cholestatic jaundice, what color will urine and stools be?

Answer 8

urine = dark
stools = pale

Question 9

if there’s itching, what type of jaundice is it?

Answer 9

cholestatic - conjugated

Question 10

is pre-hepatic conjugated or un? and why?

Answer 10

unconjugated, as its conjugated in the liver by being bound to glnucaronic acid

Question 11

tests for jaundice

Answer 11

liver enzymes: very elevated AST/ALT suggest liver disease

biliary obstruction: (US) - dilated intrahepatic bile ducts

Question 12

what is leuconychia?

Answer 12

white nails/milk spots