Flashcards in Alcoholic liver disease Deck (11)
more commonly in men
usually in 4th and 5th decades
what does alcohol act as?
3 major pathological lesions + clinical illnesses associated with excessive alcohol intake
1. fatty change
2. alcoholic hepatits
3. alcoholic cirrhosis
fatty liver (steatosis)
hepatocytes contain macro vesicular droplets of triglycerides
what does an elevated mean corpuscular volume often indicate?
histology of alcoholic hepatitis
ballooned hepatocytes, containing **mallory bodies, surrounded by neutrophils
clinical features of alcoholic hepatitis
rapid onset of jaundice
(nausea, anorexia, RUQ pain, encephalopathy, fevers)
Ix alcoholic hepatitis
FBC: leucocytosis, elevated MCV and often thrombocytopenia
Liver: elevated AST and ALT.
serum albumin is low and prothrombin time prolonged
Mx alcoholic hepatitis
supportive Tx, NG tube?
What is alcoholic cirrhosis?
final stage of liver disease from alcohol abuse
destruction of liver architecture + fibrosis, regenerating nodules