Alcoholic liver disease Flashcards Preview

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Flashcards in Alcoholic liver disease Deck (11):
1

Epidemiology

more commonly in men
usually in 4th and 5th decades

2

what does alcohol act as?

a hepatotoxin

3

3 major pathological lesions + clinical illnesses associated with excessive alcohol intake

1. fatty change
2. alcoholic hepatits
3. alcoholic cirrhosis

4

fatty liver (steatosis)

hepatocytes contain macro vesicular droplets of triglycerides

5

what does an elevated mean corpuscular volume often indicate?

heavy drinking!!!

6

histology of alcoholic hepatitis

steatosis
ballooned hepatocytes, containing **mallory bodies, surrounded by neutrophils

7

clinical features of alcoholic hepatitis

rapid onset of jaundice


(nausea, anorexia, RUQ pain, encephalopathy, fevers)

8

Ix alcoholic hepatitis

FBC: leucocytosis, elevated MCV and often thrombocytopenia

Hyponatraemia

Liver: elevated AST and ALT.
serum albumin is low and prothrombin time prolonged

9

Mx alcoholic hepatitis

supportive Tx, NG tube?

corticosteroids

10

What is alcoholic cirrhosis?

final stage of liver disease from alcohol abuse

destruction of liver architecture + fibrosis, regenerating nodules

11

Mx alcoholic cirrohsis

directed at the complications of cirrhosis
patients are advised to stop drinking for life