Flashcards in Liver failure Deck (12)
Fulminant hepatic failure
massive necrosis of liver cells --> severe impairment of liver function
Hepatic encephalopathy a.k.a postosystemic encephalopathy
Toxic substances normally detoxified by the liver bypass the liver via the collaterals and gain access to the brain.
Pt becomes increasingly drowsy + eventually comatose
(excess glutamine --> cerebral oedema)
drugs e.g. paracetamol overdose
toxins e.g. tetrachloride
vascular e.g. budd-chiari syndrome, veno-occlusive disease
others e.g. autoimmune
fetor hepaticus - foul breath/like pear drops
what causes acute-on-chronic hepatic failure?
decompensation of chronic liver disease
what is hepatic failure that occurs suddenly in a previously healthy liver?
acute hepatic failure
what imagining investigations would you perform
AXR - abnormal
Doppler flow studies of portal vein
what does neutrophils >250 on an ascitic tap indicate?
spontaneous bacterial peritonitis
Tx cerebral oedema
low salt diet
what drugs do you want to avoid?
drugs with hepatic metabolism
those that constipate (opiates, diuretics- increased risk of encephalopathy)