Coeliac disease Flashcards Preview

Liver + GI > Coeliac disease > Flashcards

Flashcards in Coeliac disease Deck (16):
1

associations

other autoimmune diseases in adults

2

prolamin

alcohol soluble proteins in wheat, barley, rye and oats

3

what is it

T-cell mediated autoimmune disease of small bowel

prolamin intolerance --> villous atrophy, crypt hyperplasia + malab

4

6 categories for the pathology of malabsorption

1. insufficient intake
2. defective intraluminal digestion
3. insufficient absorptive area
4. lack of digestive enzymes
5. defective epithelial transport
6. lymphatic obstruction

5

which malabsorption pathology category does coeliac fit into?

insufficient absorptive area

6

epidemiology

1%

7

classical presentation

diarrhoea
steatorrhoea
weight loss
failure to thrive

8

non-classical presentation

IBS-type symptoms
iron-deficiency anaemia
osteoporosis
chronic fatigue
ataxia

9

serology

tTG - tissue transglutaminase
EMA - anti-endomysal antibody
IgG + IgA

keep up the gluten before testing!!

10

endoscopy + duodenal biopsies

at least 4 duodenal biopsies and 1 duodenal bulb biopsy

11

histology

villous atrophy and crypt hyperplasia

12

marsh criteria

normal --> total villous atrophy

13

Tx

gluten free diet

DEXA scan - osteoporotic risk

Coeliac UK info

14

complications

anaemia
secondary lactose-intolerance
GI T-cell lymphoma
increased risk of cancer
myopathies

15

tropical sprue

villous atrophy + malab
far + middle east + carribean

cause unknown

16

Tx tropical sprue

tetracycline + optimum nutrition