Integumentary System Flashcards
Functions of the integumentary system
protection
defense
sensation
secretion of pre-vitamin D
thermoregulation (sweat)
blood resevoir
excretion of electrolytes
what is another term for subcutaneous fat layer
hypodermis
is the hypodermis a part of the skin
no
What is the majoirty of epidermal cells
keratinocytes- make keratin
what is meant by healthy mitotic state in epidermis
the keratinocytes live 25-45 days
get replaced
what are melanocytes and where are they
make melanin
located on basal layer of epidermis
what do melanocytes do
secrete melanin granules that percolate upward
absorb UV radiation
what do merkel cells do
sensory receptor (only one in epidermis)
where are merkel cells located
basal layer of epidermis
what are Langerhan’s cells
dendritic cells
macrophages in epidermis
what are the epidermal layers in order from top to bottom
stratum corneum
stratum lucidum (if thick skin)
stratum granulosum
stratum spinosum
stratum basale
what are the characteristics of the stratum corneum
flattened, thick keratinized cells
what does stratum corneum do
natural exfoliation
dead cells dump keratin
what are the characteristics of stratum lucidum
only in thick/hairless skin
shows bright pink above granulosum
what are the characteristics of stratum granulosum
dark landmark layer
cells begin to flatten, lose their organelles, their plasma membrane thickens
purple granules
characteristics of stratum spinosum
point looking cells with spindle fibers
major layer of live cells
resists tension
characteristics of stratum basale
basement layer
constant mitosis here
dark blobs on slide
name what can cause cancer through the integumentary system
UV radiation
what are the types of radiation and what do they do
UVA- skin aging
UVB- skin cancer; sunburns
explain squamous cell carcinoma
develops in stratum spinosa
there is some kind of failure of apoptosis leaving cells around too long to get exposed to environment
explain basal cell carcinoma
abnormal growth of basal cells
usually dont metastisize for a long time
explain melanoma
can be in tissue never exposed to sun
cancer of melanocytes
systemic reaction to radiation
very malicious; often metastisizes to other organs
What comprises the dermis
fibroblasts
fibers
mast cells
WBCs
what are the two layers of the dermis
papillary
reticular