Kidney Flashcards Preview

Anatomic pathology > Kidney > Flashcards

Flashcards in Kidney Deck (379)
Loading flashcards...
60

Metanephric adenoma: Mutation.

V600E in BRAF.

61

Metanephric adenoma: Behavior.

Benign.

62

The nuclear grading system of Fuhrman.

1: 20 μm, pleomorphic, open or dark chromatin, macronucleolus.

63

Papillary adenoma: Associations (3).

Long-term hemodialysis.

Chronic pyelonephritis.

von Hippel−Lindau syndrome.

64

Papillary adenoma:

A. Size.
B. Histologic architectural patterns (3).

A. Less than 5 mm.

B. Tubular, papillary, or both.

65

Papillary adenoma: Cytology (2).

Bland cuboidal cells.

Nuclei correspond with Fuhrman grades 1 and 2.

66

Papillary adenoma: Other histologic features (2).

Psammomatous calcifications.

Foamy histiocytes.

67

Papillary adenoma: Disqualifying cytologic feature.

Clear cytoplasm.

68

Papillary adenoma: Immunohistochemistry (2,1).

Positive: CK7, AMACR.

Negative: WT-1.

69

Papillary adenoma: Mutations (3).

+7, +17, -Y.

70

Renal oncocytoma: Radiography.

Central scar ("spoke-wheel" appearance).

71

Renal oncocytoma: Histologic patterns (3).

Classic: Well-defined nests of oncocytes.

Tubulocystic: Tubules and cysts contain eosinophilic secretions.

Mixed: Nests and tubules.

72

Renal oncocytoma: "Tolerable" histopathologic anomalies (3).

Occasional smudged nuclei.

Occasional clear cells.

Focal extension into perinephric fat.

73

Renal oncocytoma: Features that are incompatible with the diagnosis (4).

Gross extension into the perinephric fat.

Papillae.

Sarcomatoid or spindle-cell areas.

Atypical mitotic figures.

74

Renal oncocytoma: Immunohistochemistry (4,1),

Positive: CK7, S100, E-cadherin, claudin 8 (cytoplasmic).

Negative: Vimentin.

75

Renal oncocytoma: Special stain.

Negative: Hale's colloidal iron.

76

Renal oncocytoma: Mutation.

t(5;11) in some cases.

77

Renal oncocytoma vs. clear-cell RCC with eosinophilic cytoplasm: Immunohistochemistry (3).

Clear-cell RCC expresses vimentin but neither CK7 nor E-cadherin.

78

Renal oncocytosis: Causes (2).

Sporadic.

Chronic renal failure.

79

Renal oncocytoma: Putative origin.

Intercalated cells of the collecting ducts.

80

Birt-Hogg-Dubé syndrome: Renal tumor.

Combines features of renal oncocytoma and chromophobe RCC.

81

Renal-cell carcinoma, clear-cell type: Classic presentation.

Pain, flank mass, hematuria: Reported in only 10% of patients.

82

Renal-cell carcinoma, clear-cell type: Genes (4).

VHL.

PBRM1.

BAP1.

SETD2.

83

Renal-cell carcinoma, clear-cell type vs. clear-cell papillary renal-cell carcinoma: Immunohistochemistry.

Clear-cell papillary renal-cell carcinoma . . .

− Positive: CK7 and keratin 34βE12.
− Negative: CD10, AMACR.

Both tumors express CA9.

84

Renal-cell carcinoma, clear-cell type vs. adrenocortical carcinoma: Immunohistochemistry (2).

Adrenocortical carcinoma . . .

− Positive: Inhibin, calretinin.
− Negative: EMA, cytokeratins.

85

Clear-cell papillary renal-cell carcinoma: Cytology (2).

Clear cells with low-grade nuclei.

Nuclei are oriented away from the basement membrane and toward the lumen.

86

Renal-cell carcinoma, papillary type: Syndrome, gene, location.

Hereditary papillary RCC syndrome: c-met on chromosome 7q31.

87

Renal-cell carcinoma, papillary type: Gross pathology (2).

Fibrous pseudocapsule.

May be multifocal or bilateral.

88

Renal-cell carcinoma, papillary type, type I: Histopathology.

Papillae are lined by a single layer of cells with low-grade nuclear features and scant cytoplasm.

89

Renal-cell carcinoma, papillary type, type II: Histopathology.

Papillae are lined by pseudostratified cells of higher nuclear grade and much cytoplasm.