Flashcards in Kidney Deck (379)
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120
Mucinous tubular and spindle-cell carcinoma: Histopathologic components (3).
Elongated and compressed tubules.
Spindle-shaped epithelial cells.
Extracellular mucinous Krappe.
121
Mucinous tubular and spindle-cell carcinoma: Cytology.
Bland cells with inconspicuous nucleoli.
122
Mucinous tubular and spindle-cell carcinoma: Immunohistochemistry (2,2).
Positive: Cytokeratins, AMACR.
Negative: CD10, villin (markers of proximal tubules).
123
Renal-cell carcinoma with translocations involving TFE3: Epidemiology.
Affects mainly children and young adults.
124
Renal-cell carcinoma with translocations involving TFE3: Location of TFE3 gene.
Xp11.2.
125
Renal-cell carcinoma with translocations involving TFE3: Most common translocation partners of TFE3 (2).
ASPL (17q25): Advanced stage at presentation.
PRCC (1q21).
126
Renal-cell carcinoma with translocations involving TFE3: Histopathologic patterns (2).
Papillary and nested.
127
Renal-cell carcinoma with translocations involving TFE3: Cytology (4).
Clear or pink cytoplasm.
Discrete cell borders.
Vesicular chromatin.
Large nucleoli.
128
Renal-cell carcinoma with translocations involving TFE3: Extracellular features (2).
Psammoma bodies.
Hyaline nodules.
129
Renal-cell carcinoma with translocations involving TFE3: Effect of translocation partner on histopathology (2).
ASPL: Cells have more cytoplasm; more psammoma bodies, more hyaline nodules.
PRCC: Less of all three.
130
Renal-cell carcinoma with translocations involving TFE3: Immunohistochemistry (4).
Positive: TFE3, cathepsin K, CD10, RCC.
131
Renal-cell carcinoma with t(6;11):
A. Epidemiology.
B. Prognosis.
A. Affects mainly children and young adults.
B. Similar to that of conventional RCC.
132
Renal-cell carcinoma with t(6;11): Gene.
TFEB on chromosome 6p21.
133
Renal-cell carcinoma with t(6;11): Cellular components (2).
Polygonal epithelioid cells with discrete borders.
Smaller cells with dark nuclei, forming clusters around hyaline matter.
Mitotic figures are rare.
134
Renal-cell carcinoma with t(6;11): Architecture.
Tubular, micropapillary.
135
Renal-cell carcinoma with t(6;11): Immunohistochemistry (2,2).
Positive: TFEB, melanoma markers.
Negative: TFE, epithelial markers.
136
Renal-cell carcinoma associated with neuroblastoma: Timing.
Diagnosed around 10 years after the original diagnosis of neuroblastoma.
137
Sarcomatoid differentiation in renal-cell carcinoma:
A. Setting.
B. Significance.
A. Can occur in any type of renal-cell carcinoma.
B. Imparts poor prognosis.
138
Sarcomatoid differentiation in renal-cell carcinoma: Histopathology (3).
Nondescript spindle cells.
May resemble MFH.
May resemble leiomyosarcoma or other differentiated sarcoma.
139
Sarcomatoid differentiation in renal-cell carcinoma: Immunohistochemistry.
May express epithelial markers and PAX8.
May not express other markers that are expressed in the better-differentiated parts of the tumor.
140
Renal tumors that contain spindle cells (4).
Any carcinoma with sarcomatoid differentiation.
Any carcinoma (esp. conventional) containing a scar.
Mucinous tubular and spindle-cell carcinoma.
Primary renal sarcoma.
141
Renal-cell carcinoma, unclassified: Examples of histopathology (3).
A tumor combining features of recognized renal tumors.
A tumor showing sarcomatoid differentiation only.
A high-grade tumor.
142
Cystic nephroma: Typical patient.
Middle-aged female.
143
Cystic nephroma: Presentation and behavior.
Asymptomatic and benign.
144
Cystic nephroma: Gross pathology.
Consists of many cystic spaces that do not communicate with the renal pelvis.
145
Cystic nephroma: Histopathology (2).
Cysts lined by bland cells.
Ovarian-type or hyalinized stroma.
146
Cystic nephroma: Disqualifying histopathologic feature.
Nephronic elements in the stroma.
147
Cystic nephroma: Immunohistochemistry.
Ovarian-type stroma expresses ER and PR.
148
Cystic nephroma: Significance of pediatric type.
Considered a variant of nephroblastoma.
149
