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Anatomic pathology > Kidney > Flashcards

Flashcards in Kidney Deck (379)
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120

Mucinous tubular and spindle-cell carcinoma: Histopathologic components (3).

Elongated and compressed tubules.

Spindle-shaped epithelial cells.

Extracellular mucinous Krappe.

121

Mucinous tubular and spindle-cell carcinoma: Cytology.

Bland cells with inconspicuous nucleoli.

122

Mucinous tubular and spindle-cell carcinoma: Immunohistochemistry (2,2).

Positive: Cytokeratins, AMACR.

Negative: CD10, villin (markers of proximal tubules).

123

Renal-cell carcinoma with translocations involving TFE3: Epidemiology.

Affects mainly children and young adults.

124

Renal-cell carcinoma with translocations involving TFE3: Location of TFE3 gene.

Xp11.2.

125

Renal-cell carcinoma with translocations involving TFE3: Most common translocation partners of TFE3 (2).

ASPL (17q25): Advanced stage at presentation.

PRCC (1q21).

126

Renal-cell carcinoma with translocations involving TFE3: Histopathologic patterns (2).

Papillary and nested.

127

Renal-cell carcinoma with translocations involving TFE3: Cytology (4).

Clear or pink cytoplasm.

Discrete cell borders.

Vesicular chromatin.

Large nucleoli.

128

Renal-cell carcinoma with translocations involving TFE3: Extracellular features (2).

Psammoma bodies.

Hyaline nodules.

129

Renal-cell carcinoma with translocations involving TFE3: Effect of translocation partner on histopathology (2).

ASPL: Cells have more cytoplasm; more psammoma bodies, more hyaline nodules.

PRCC: Less of all three.

130

Renal-cell carcinoma with translocations involving TFE3: Immunohistochemistry (4).

Positive: TFE3, cathepsin K, CD10, RCC.

131

Renal-cell carcinoma with t(6;11):

A. Epidemiology.
B. Prognosis.

A. Affects mainly children and young adults.

B. Similar to that of conventional RCC.

132

Renal-cell carcinoma with t(6;11): Gene.

TFEB on chromosome 6p21.

133

Renal-cell carcinoma with t(6;11): Cellular components (2).

Polygonal epithelioid cells with discrete borders.

Smaller cells with dark nuclei, forming clusters around hyaline matter.

Mitotic figures are rare.

134

Renal-cell carcinoma with t(6;11): Architecture.

Tubular, micropapillary.

135

Renal-cell carcinoma with t(6;11): Immunohistochemistry (2,2).

Positive: TFEB, melanoma markers.

Negative: TFE, epithelial markers.

136

Renal-cell carcinoma associated with neuroblastoma: Timing.

Diagnosed around 10 years after the original diagnosis of neuroblastoma.

137

Sarcomatoid differentiation in renal-cell carcinoma:

A. Setting.
B. Significance.

A. Can occur in any type of renal-cell carcinoma.

B. Imparts poor prognosis.

138

Sarcomatoid differentiation in renal-cell carcinoma: Histopathology (3).

Nondescript spindle cells.

May resemble MFH.

May resemble leiomyosarcoma or other differentiated sarcoma.

139

Sarcomatoid differentiation in renal-cell carcinoma: Immunohistochemistry.

May express epithelial markers and PAX8.

May not express other markers that are expressed in the better-differentiated parts of the tumor.

140

Renal tumors that contain spindle cells (4).

Any carcinoma with sarcomatoid differentiation.

Any carcinoma (esp. conventional) containing a scar.

Mucinous tubular and spindle-cell carcinoma.

Primary renal sarcoma.

141

Renal-cell carcinoma, unclassified: Examples of histopathology (3).

A tumor combining features of recognized renal tumors.

A tumor showing sarcomatoid differentiation only.

A high-grade tumor.

142

Cystic nephroma: Typical patient.

Middle-aged female.

143

Cystic nephroma: Presentation and behavior.

Asymptomatic and benign.

144

Cystic nephroma: Gross pathology.

Consists of many cystic spaces that do not communicate with the renal pelvis.

145

Cystic nephroma: Histopathology (2).

Cysts lined by bland cells.

Ovarian-type or hyalinized stroma.

146

Cystic nephroma: Disqualifying histopathologic feature.

Nephronic elements in the stroma.

147

Cystic nephroma: Immunohistochemistry.

Ovarian-type stroma expresses ER and PR.

148

Cystic nephroma: Significance of pediatric type.

Considered a variant of nephroblastoma.

149

Cystic nephroma vs. nephrogenic adenoma vs. metanephric adenoma.

Cystic nephroma: Bland cysts and ovarian-type stroma.

Nephrogenic adenoma: Renal-tubular-like proliferation outside the kidneys.

Metanephric adenoma: Small acini consisting of small, dark cells.