Flashcards in Kidney Deck (379)
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150
Mixed epithelial and stromal tumor: Epidemiology and putative etiology.
Mostly in females; estrogen imbalance.
151
Mixed epithelial and stromal tumor: Gross pathology (2).
Central location in the kidney.
Contains cystic (epithelial) and solid (stromal) areas.
152
Mixed epithelial and stromal tumor vs. cystic nephroma.
MEST
− Epithelial component: Tubules as well as cells.
− Stromal component: Grossly evident; histologically more variable (e.g. fat, smooth muscle).
Both tumors are considered part of the same spectrum.
153
Tubulocystic carcinoma: Typical patient.
Middle-aged man.
154
Tubulocystic carcinoma: Gross pathology (3).
Entirely cystic, resembling bubble wrap.
Well circumscribed but has no capsule.
155
Tubulocystic carcinoma: Histopathology.
Closely packed cysts separated by delicate septa or a fibrotic stroma.
No tumor cells in those septa.
156
Tubulocystic carcinoma: Cytology.
Cells resemble hobnails and contain large nucleoli.
157
Tubulocystic carcinoma: Immunohistochemistry (2,1).
Positive: CD10, AMACR.
Negative: CD7.
158
Tubulocystic carcinoma vs. multilocular cystic renal-cell carcinoma.
Multilocular cystic renal-cell carcinoma: Nests of clear cells in the septa.
159
Clear-cell tubulopapillary renal-cell carcinoma: Behavior.
Low grade, low stage.
160
Clear-cell tubulopapillary renal-cell carcinoma: Gross pathology.
Cystic; fibrous capsule.
161
Clear-cell tubulopapillary renal-cell carcinoma: Architecture (3).
Papillae, tubules, cysts.
162
Clear-cell tubulopapillary renal-cell carcinoma: Cytology.
Clear cytoplasm.
Bland nuclei (Fuhrman grade 1 or 2).
Nuclei are oriented toward the lumens and away from the basement membranes.
163
Clear-cell tubulopapillary renal-cell carcinoma: Cytogenetics.
No +7, +17, -Y.
No -3p.
164
Clear-cell tubulopapillary renal-cell carcinoma: Immunohistochemistry (2,2).
Positive: CK7 (membranous), CA9.
Negative: AMACR, CD10.
165
Hereditary leiomyomatosis:
A. Inheritance.
B. Tumors (3).
A. Autosomal dominant.
B. Leiomyomas, uterine leiomyosarcoma, renal-cell carcinoma.
166
Hereditary leiomyomatosis: Gene and its location.
Fumarate hydratase on 1q42.
167
Renal-cell carcinoma of hereditary leiomyomatosis: Architecture.
Similar to that of papillary RCC, type II.
168
Renal-cell carcinoma of hereditary leiomyomatosis: Cytology.
Large nucleus contains a very large, red nucleolus with a clear halo.
169
Renal-cell carcinoma of hereditary leiomyomatosis: Immunohistochemistry.
Positive: 2SC (2-succinylcysteine).
170
Renal-cell carcinoma of hereditary leiomyomatosis: Prognosis.
Poor.
171
Birt-Hogg-Dubé syndrome: Skin tumors (3).
Fibrofolliculoma.
Trichodiscoma.
Acrochordons.
172
Birt-Hogg-Dubé syndrome: Gene, location, product.
BHD, 17p11.2, folliculin.
173
Renal-cell carcinoma associated with Birt-Hogg-Dubé syndrome: Histopathology (3).
Oncocytoma + chromophobe RCC.
Oncocytosis outside the tumor.
Clear cells without wrinkled nuclei.
174
Renal-cell carcinoma associated with Birt-Hogg-Dubé syndrome: Immunohistochemistry (3).
Positive: CK7, CD117, parvalbumin.
175
Renal-cell carcinoma associated with Birt-Hogg-Dubé syndrome: Prognosis.
Excellent; no aggressive behavior reported.
176
SDH syndrome: Tumors (3).
Paraganglioma / pheochromocytoma.
Gastrointestinal stromal tumor.
Renal-cell carcinoma.
177
SDH syndrome: Genes.
SDHB, SDHC, SDHD: Subunits of succinate dehydrogenase in Krebs' cycle.
178
Renal-cell carcinoma of SDH syndrome: Mean age at presentation.
33 years.
179
