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Anatomic pathology > Kidney > Flashcards

Flashcards in Kidney Deck (379)
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150

Mixed epithelial and stromal tumor: Epidemiology and putative etiology.

Mostly in females; estrogen imbalance.

151

Mixed epithelial and stromal tumor: Gross pathology (2).

Central location in the kidney.

Contains cystic (epithelial) and solid (stromal) areas.

152

Mixed epithelial and stromal tumor vs. cystic nephroma.

MEST
− Epithelial component: Tubules as well as cells.
− Stromal component: Grossly evident; histologically more variable (e.g. fat, smooth muscle).

Both tumors are considered part of the same spectrum.

153

Tubulocystic carcinoma: Typical patient.

Middle-aged man.

154

Tubulocystic carcinoma: Gross pathology (3).

Entirely cystic, resembling bubble wrap.

Well circumscribed but has no capsule.

155

Tubulocystic carcinoma: Histopathology.

Closely packed cysts separated by delicate septa or a fibrotic stroma.

No tumor cells in those septa.

156

Tubulocystic carcinoma: Cytology.

Cells resemble hobnails and contain large nucleoli.

157

Tubulocystic carcinoma: Immunohistochemistry (2,1).

Positive: CD10, AMACR.

Negative: CD7.

158

Tubulocystic carcinoma vs. multilocular cystic renal-cell carcinoma.

Multilocular cystic renal-cell carcinoma: Nests of clear cells in the septa.

159

Clear-cell tubulopapillary renal-cell carcinoma: Behavior.

Low grade, low stage.

160

Clear-cell tubulopapillary renal-cell carcinoma: Gross pathology.

Cystic; fibrous capsule.

161

Clear-cell tubulopapillary renal-cell carcinoma: Architecture (3).

Papillae, tubules, cysts.

162

Clear-cell tubulopapillary renal-cell carcinoma: Cytology.

Clear cytoplasm.

Bland nuclei (Fuhrman grade 1 or 2).

Nuclei are oriented toward the lumens and away from the basement membranes.

163

Clear-cell tubulopapillary renal-cell carcinoma: Cytogenetics.

No +7, +17, -Y.

No -3p.

164

Clear-cell tubulopapillary renal-cell carcinoma: Immunohistochemistry (2,2).

Positive: CK7 (membranous), CA9.

Negative: AMACR, CD10.

165

Hereditary leiomyomatosis:

A. Inheritance.
B. Tumors (3).

A. Autosomal dominant.

B. Leiomyomas, uterine leiomyosarcoma, renal-cell carcinoma.

166

Hereditary leiomyomatosis: Gene and its location.

Fumarate hydratase on 1q42.

167

Renal-cell carcinoma of hereditary leiomyomatosis: Architecture.

Similar to that of papillary RCC, type II.

168

Renal-cell carcinoma of hereditary leiomyomatosis: Cytology.

Large nucleus contains a very large, red nucleolus with a clear halo.

169

Renal-cell carcinoma of hereditary leiomyomatosis: Immunohistochemistry.

Positive: 2SC (2-succinylcysteine).

170

Renal-cell carcinoma of hereditary leiomyomatosis: Prognosis.

Poor.

171

Birt-Hogg-Dubé syndrome: Skin tumors (3).

Fibrofolliculoma.

Trichodiscoma.

Acrochordons.

172

Birt-Hogg-Dubé syndrome: Gene, location, product.

BHD, 17p11.2, folliculin.

173

Renal-cell carcinoma associated with Birt-Hogg-Dubé syndrome: Histopathology (3).

Oncocytoma + chromophobe RCC.

Oncocytosis outside the tumor.

Clear cells without wrinkled nuclei.

174

Renal-cell carcinoma associated with Birt-Hogg-Dubé syndrome: Immunohistochemistry (3).

Positive: CK7, CD117, parvalbumin.

175

Renal-cell carcinoma associated with Birt-Hogg-Dubé syndrome: Prognosis.

Excellent; no aggressive behavior reported.

176

SDH syndrome: Tumors (3).

Paraganglioma / pheochromocytoma.

Gastrointestinal stromal tumor.

Renal-cell carcinoma.

177

SDH syndrome: Genes.

SDHB, SDHC, SDHD: Subunits of succinate dehydrogenase in Krebs' cycle.

178

Renal-cell carcinoma of SDH syndrome: Mean age at presentation.

33 years.

179

Renal-cell carcinoma of SDH syndrome: Histopathology (2).

Mutation in SDHB: Consists of oncocytes containing large vacuoles and bland nuclei.

Mutation in SDHC or SDHD: Resembles clear-cell RCC.