Kidney Flashcards Preview

Anatomic pathology > Kidney > Flashcards

Flashcards in Kidney Deck (379)
Loading flashcards...
180

Renal-cell carcinoma of SDH syndrome: Prognosis.

May be aggressive, especially in younger patients.

181

Renal-cell carcinoma associated with acquired cystic disease: Risk factors (2).

Male gender.

Long-term dialysis.

182

Renal-cell carcinoma associated with acquired cystic disease: Architecture.

Mixture of sheets, nests, tubulopapillary areas, and cystic areas.

183

Renal-cell carcinoma associated with acquired cystic disease: Cytology (2).

Eosinophilic cytoplasm.

Nuclei of Fuhrman grade 3.

184

Renal-cell carcinoma associated with acquired cystic disease: Intracellular features (2).

Microlumens, hemosiderin.

185

Renal-cell carcinoma associated with acquired cystic disease: Extracellular feature.

Oxalate crystals.

186

Renal-cell carcinoma associated with acquired cystic disease: Immunohistochemistry (2,3).

Positive: AMACR, CD10.

Negative: CA9, PAX8, CK7.

187

Renal medullary interstitial-cell tumor / medullary fibroma: Presentation.

Asymptomatic; found incidentally.

188

Renal medullary interstitial-cell tumor / medullary fibroma: Histopathology.

Medullary tubules entrapped in a paucicellular matrix that is collagenous or myxoid.

189

Renal medullary interstitial-cell tumor / medullary fibroma: Cell of origin.

Renal medullary interstitial cell, which helps to control the blood pressure.

190

Juxtaglomerular-cell tumor: Presentation.

Hypertension.

191

Juxtaglomerular-cell tumor: Laboratory findings (3).

Elevated plasma renin.

Elevated aldosterone.

Hypokalemia.

192

Juxtaglomerular-cell tumor: Location.

Renal cortex.

193

Juxtaglomerular-cell tumor: Architecture (3).

Trabeculae or glomeruloid formations.

Myxoid stroma containing lymphocytes.

Hemangiopericytoma-like vasculature.

194

Juxtaglomerular-cell tumor: Cytology (3).

Polygonal or spindle shape.

Moderate or abundant pink, granular cytoplasm.

Bland nuclei.

195

Juxtaglomerular-cell tumor: Immunohistochemistry (2,3).

Positive: CD31, actins.

Negative: Cytokeratins, desmin, melanoma markers.

196

Juxtaglomerular-cell tumor: Electron microscopy.

Rhomboid crystals of renin.

197

Juxtaglomerular-cell tumor: Prognosis.

Never reported to recur or metastasize.

198

Nephroblastoma: Age group.

Children below the age of 6.

199

Nephroblastoma: Syndromes (4).

WAGR.

Denys-Drash.

Beckwith-Wiedemann.

Familial neuroblastoma.

200

WAGR syndrome:

A. Components.
B. Mutation.

A. Wilms' tumor, aniridia, genital anomalies, mental retardation.

B. del(11p13), including WT1.

201

Denys-Drash syndrome: Mutation.

Point mutation in WT1.

202

Beckwith-Wiedemann: Gene.

WT2 on 11p15.

203

Nephroblastoma: Typical presentation.

Abdominal mass or tenderness.

204

Nephroblastoma:

A. Histological components (3).
B. Variation.

A. Blastemal, stromal, epithelial.

B. Only two or only one component may be represented.

205

Nephroblastoma: Blastema.

Consists of small, round, blue cells with coarse chromatin.

206

Nephroblastoma: Stroma (2).

Myxoid or fibromyxoid.

May show differentiation toward skeletal muscle, cartilage, etc.

207

Nephroblastoma: Epithelial component (2).

Poorly or well-formed tubules and papillae.

Squamous or mucinous foci may be seen.

208

Nephroblastoma: Definition of nuclear anaplasia (3).

Polyploidy

− or −

Multipolar mitotic figures

− or −

Greater-than-threefold variation in nuclear size.

209

Nephroblastoma: Significance of nuclear anaplasia.

Predicts responsiveness to chemotherapy.