Flashcards in Kidney Deck (379)
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180
Renal-cell carcinoma of SDH syndrome: Prognosis.
May be aggressive, especially in younger patients.
181
Renal-cell carcinoma associated with acquired cystic disease: Risk factors (2).
Male gender.
Long-term dialysis.
182
Renal-cell carcinoma associated with acquired cystic disease: Architecture.
Mixture of sheets, nests, tubulopapillary areas, and cystic areas.
183
Renal-cell carcinoma associated with acquired cystic disease: Cytology (2).
Eosinophilic cytoplasm.
Nuclei of Fuhrman grade 3.
184
Renal-cell carcinoma associated with acquired cystic disease: Intracellular features (2).
Microlumens, hemosiderin.
185
Renal-cell carcinoma associated with acquired cystic disease: Extracellular feature.
Oxalate crystals.
186
Renal-cell carcinoma associated with acquired cystic disease: Immunohistochemistry (2,3).
Positive: AMACR, CD10.
Negative: CA9, PAX8, CK7.
187
Renal medullary interstitial-cell tumor / medullary fibroma: Presentation.
Asymptomatic; found incidentally.
188
Renal medullary interstitial-cell tumor / medullary fibroma: Histopathology.
Medullary tubules entrapped in a paucicellular matrix that is collagenous or myxoid.
189
Renal medullary interstitial-cell tumor / medullary fibroma: Cell of origin.
Renal medullary interstitial cell, which helps to control the blood pressure.
190
Juxtaglomerular-cell tumor: Presentation.
Hypertension.
191
Juxtaglomerular-cell tumor: Laboratory findings (3).
Elevated plasma renin.
Elevated aldosterone.
Hypokalemia.
192
Juxtaglomerular-cell tumor: Location.
Renal cortex.
193
Juxtaglomerular-cell tumor: Architecture (3).
Trabeculae or glomeruloid formations.
Myxoid stroma containing lymphocytes.
Hemangiopericytoma-like vasculature.
194
Juxtaglomerular-cell tumor: Cytology (3).
Polygonal or spindle shape.
Moderate or abundant pink, granular cytoplasm.
Bland nuclei.
195
Juxtaglomerular-cell tumor: Immunohistochemistry (2,3).
Positive: CD31, actins.
Negative: Cytokeratins, desmin, melanoma markers.
196
Juxtaglomerular-cell tumor: Electron microscopy.
Rhomboid crystals of renin.
197
Juxtaglomerular-cell tumor: Prognosis.
Never reported to recur or metastasize.
198
Nephroblastoma: Age group.
Children below the age of 6.
199
Nephroblastoma: Syndromes (4).
WAGR.
Denys-Drash.
Beckwith-Wiedemann.
Familial neuroblastoma.
200
WAGR syndrome:
A. Components.
B. Mutation.
A. Wilms' tumor, aniridia, genital anomalies, mental retardation.
B. del(11p13), including WT1.
201
Denys-Drash syndrome: Mutation.
Point mutation in WT1.
202
Beckwith-Wiedemann: Gene.
WT2 on 11p15.
203
Nephroblastoma: Typical presentation.
Abdominal mass or tenderness.
204
Nephroblastoma:
A. Histological components (3).
B. Variation.
A. Blastemal, stromal, epithelial.
B. Only two or only one component may be represented.
205
Nephroblastoma: Blastema.
Consists of small, round, blue cells with coarse chromatin.
206
Nephroblastoma: Stroma (2).
Myxoid or fibromyxoid.
May show differentiation toward skeletal muscle, cartilage, etc.
207
Nephroblastoma: Epithelial component (2).
Poorly or well-formed tubules and papillae.
Squamous or mucinous foci may be seen.
208
Nephroblastoma: Definition of nuclear anaplasia (3).
Polyploidy
− or −
Multipolar mitotic figures
− or −
Greater-than-threefold variation in nuclear size.
209
