Flashcards in Kidney Deck (379)
Renal-cell carcinoma of SDH syndrome: Prognosis.
May be aggressive, especially in younger patients.
Renal-cell carcinoma associated with acquired cystic disease: Risk factors (2).
Renal-cell carcinoma associated with acquired cystic disease: Architecture.
Mixture of sheets, nests, tubulopapillary areas, and cystic areas.
Renal-cell carcinoma associated with acquired cystic disease: Cytology (2).
Nuclei of Fuhrman grade 3.
Renal-cell carcinoma associated with acquired cystic disease: Intracellular features (2).
Renal-cell carcinoma associated with acquired cystic disease: Extracellular feature.
Renal-cell carcinoma associated with acquired cystic disease: Immunohistochemistry (2,3).
Positive: AMACR, CD10.
Negative: CA9, PAX8, CK7.
Renal medullary interstitial-cell tumor / medullary fibroma: Presentation.
Asymptomatic; found incidentally.
Renal medullary interstitial-cell tumor / medullary fibroma: Histopathology.
Medullary tubules entrapped in a paucicellular matrix that is collagenous or myxoid.
Renal medullary interstitial-cell tumor / medullary fibroma: Cell of origin.
Renal medullary interstitial cell, which helps to control the blood pressure.
Juxtaglomerular-cell tumor: Presentation.
Juxtaglomerular-cell tumor: Laboratory findings (3).
Elevated plasma renin.
Juxtaglomerular-cell tumor: Location.
Juxtaglomerular-cell tumor: Architecture (3).
Trabeculae or glomeruloid formations.
Myxoid stroma containing lymphocytes.
Juxtaglomerular-cell tumor: Cytology (3).
Polygonal or spindle shape.
Moderate or abundant pink, granular cytoplasm.
Juxtaglomerular-cell tumor: Immunohistochemistry (2,3).
Positive: CD31, actins.
Negative: Cytokeratins, desmin, melanoma markers.
Juxtaglomerular-cell tumor: Electron microscopy.
Rhomboid crystals of renin.
Juxtaglomerular-cell tumor: Prognosis.
Never reported to recur or metastasize.
Nephroblastoma: Age group.
Children below the age of 6.
Nephroblastoma: Syndromes (4).
A. Wilms' tumor, aniridia, genital anomalies, mental retardation.
B. del(11p13), including WT1.
Denys-Drash syndrome: Mutation.
Point mutation in WT1.
WT2 on 11p15.
Nephroblastoma: Typical presentation.
Abdominal mass or tenderness.
A. Histological components (3).
A. Blastemal, stromal, epithelial.
B. Only two or only one component may be represented.
Consists of small, round, blue cells with coarse chromatin.
Nephroblastoma: Stroma (2).
Myxoid or fibromyxoid.
May show differentiation toward skeletal muscle, cartilage, etc.
Nephroblastoma: Epithelial component (2).
Poorly or well-formed tubules and papillae.
Squamous or mucinous foci may be seen.
Nephroblastoma: Definition of nuclear anaplasia (3).
− or −
Multipolar mitotic figures
− or −
Greater-than-threefold variation in nuclear size.