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Anatomic pathology > Kidney > Flashcards

Flashcards in Kidney Deck (379)
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210

Nephroblastoma: Immunohistochemistry for WT1.

Blastema and undifferentiated epithelium: Diffuse expression.

Stroma: Little or no expression.

Differentiated epithelium: Variable.

211

Nephroblastoma: Distinction from other tumors of small, round, blue cells (2).

IHC: Expression of WT-1 by nephroblastoma.

EM: Variety of organelles in blastemal cells of nephroblastoma.

212

Nephroblastoma: Sites of metastasis (3).

Lymph nodes, liver, lung.

213

Nephroblastoma: Prognosis (2).

About 90% of cases get cured.

Younger patients do better.

214

Nephrogenic rest:

A. Significance.
B. State of multiplicity.

A. Increased likelihood of contralateral nephroblastoma.

B. Nephroblastomatosis.

215

Nephroblastoma: Histopathology (2).

Perilobar type: Mainly blastema and tubules; very little stroma.

Intralobar type: Rich in stroma.

216

Cystic partially differentiated nephroblastoma: Histopathology (3).

Epithelial-lined cysts or unlined cyst-like structures.

Septa may contain nephroblastomatous epithelium.

No expansile solid component.

217

Cystic partially differentiated nephroblastoma: Variant.

Pediatric cystic nephroma contains no nephroblastomatous elements.

218

Cystic partially differentiated nephroblastoma vs. Cystic nephroblastoma.

The latter has an expansile solid component.

219

Mesoblastic nephroma: Epidemiology (2).

Patients are usually no more than 3 months old.

Most frequent congenital renal neoplasm.

220

Mesoblastic nephroma: Presentation.

Abdominal mass.

221

Mesoblastic nephroma: Behavior (2).

Excellent if completely resected.

222

Mesoblastic nephroma: Location.

Renal sinus.

223

Mesoblastic nephroma: Gross pathology (2).

Classic: Small; firm; resembles leiomyoma.

Cellular: Large; soft; cystic; focally hemorrhagic and necrotic.

224

Mesoblastic nephroma: Histopathology of classic type.

Resembles benign fibromatosis.

225

Mesoblastic nephroma: Histopathology of cellular type.

Sheets or vague fascicles of densely packed, plump, mitotically active cells.

Same as infantile fibrosarcoma.

226

Mesoblastic nephroma: Immunohistochemistry (2).

Positive: SMA, vimentin.

227

Mesoblastic nephroma: Electron microscopy.

Much endoplasmic reticulum.

228

Mesoblastic nephroma: Translocation.

t(12;15)(p13;q25).

229

Mesoblastic nephroma vs. cystic nephroma.

Mesoblastic nephroma: Spindle-cell mesenchymal tumor in infants.

Cystic nephroma: Bland cysts and ovarian-type stroma; occurs mainly in women.

230

Mesoblastic nephroma vs. metanephric adenoma.

Mesoblastic nephroma: Spindle-cell mesenchymal tumor in infants.

Metanephric adenoma: Small acini consisting of small, dark cells; occurs in adults.

231

Clear-cell sarcoma: Age group.

Between 6 months and 5 years.

232

Clear-cell sarcoma: Cytology of classic type (3).

Cytoplasm: Pale.

Nucleus: Vesicular.

Nucleolus: Inconspicuous.

233

Clear-cell sarcoma: Histopathology of classic type (2).

Cells form cords that are separated by regularly spaced fibrovascular arcades.

Normal renal structures are entrapped at the periphery of the tumor.

234

Clear-cell sarcoma: Variants (3).

Myxoid, sclerosing, epithelioid, many others.

235

Clear-cell sarcoma: Immunohistochemistry (2,3).

Positive: Vimentin, nerve-growth-factor receptor.

Negative: Cytokeratins, neural markers, WT1.

236

Clear-cell sarcoma: Prognosis.

Very aggressive.

237

Rhabdoid tumor: Age at presentation.

Usually less than 2 years.

238

Rhabdoid tumor:

A. Laboratory findings.
B. Associated tumor.

A. Hypercalcemia, hematuria.

B. PNET of the posterior fossa.

239

Rhabdoid tumor: Cytology.

Cytoplasm: Abundant, pink; often contains large eosinophilic globular inclusions.

Nucleus: Vesicular; thick membrane.

Nucleolus: Large.