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Flashcards in KNOW THIS Deck (121)
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31

Lead poisoning Sx

encephalopathy, foot/wrist drop, lead lines on gingiva, abd pain, basophilic stippling

32

Lead poisoning Tx

EDTA/succimer, if severe -> Dimercaprol

33

Lead poisoning MOA

inhibits heme synthesis (blocks ALA dehydratase & Ferrochelatase)

34

Tumors that can cause polycythemia vera

Pheochromocytoma, Renal cell carcinoma, HCC, Hemangioblastoma

35

Shine-Delgarno element

downstream from AUG start codon in prokaryotes, recognizes 16S rRNA & 30S subunit

36

Streptomycin MOA

inhibits the initiation of protein synthesis by binding & distorting 30S ribosome structure

37

Fomepizol MOA

inhibits alcohol dehydrogenase

38

Disulfiram MOA

inhibits acetaldehyde dehydrogenase

39

Order of the speed of conduction w/in the heart

Fast->Slow: Purkinje -> Atrial mm. -> Venricular mm. -> AV node

40

Pancoast tumors often compress

brachial plexus to cause I/L shoulder pain & cervical sympathetic chain to cause Horner's syndrome

41

Pancoast tumor origin

Squamous cell carcinoma or Adenocarcinoma

42

Tumor w/ high thymidine uptake suggest

high DNA synthesis -> high grade

43

Azoles MOA

inhibit the synthesis of Ergosterol by the fungal cytochrome P450 enzymes

44

Auer rods

Acute Myelogenous Leukemia

45

Causes of Vitamin B12 def

low intake, pernicious anemia, celiacs, Diphyllobothrium latum

46

Hexokinase v Glucokinase

Hexokinase is found in most cells (low Km, high affinity)
Glucokinase is found in hepatocytes & b-cells (high Km, high Vmax)

47

Pyruvate dehydrogenase cofactors

Thiamine, Lipoic acid, CoA, FAD, NAD+

48

Substrate & cofactor for GABA production

Glutamate + B6

49

Hb Barts

4 gamma globin chains -> fatal

50

Tx of hemochromatosis

Deferoxamine

51

Orotic aciduria - enzyme deficiency

UMP synthase

52

Orotic aciduria - Sx

megaloblastic anemia, no hyperammonemia

53

RLS of beta-oxidation of fatty acids

Carnitine Acyltransferase-1

54

Dx test for Hereditary spherocytosis

Osmotic fragility test

55

Paroxysmal Nocturnal Hemoglobinuria - deficiency

missing CD55 & CD59 -> complement attacks RBCs

56

Cold Agglutinins

IgM production d/t EBV, Mycoplasma --> RBC lysis

57

Osteomyelitis in Sickle Cell pt

Salmonella

58

Tx for Sickle Cell pt

Hydroxyurea

59

Warm Agglutinins

IgG production d/t Virus, Lupus, Malignancy, Congenital immune abnormality --> RBC lysis

60

Infectious agents that may cause brown gallstones

E. coli, Ascaris lumbricoides, O. sinensis