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Flashcards in KNOW THIS Deck (121)
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61

Enzyme released by injured hepatocytes that may cause brown gallstones

b-glucuronidase

62

7a-hydroxylase MOA

converts cholesterol to bile acids (reducing the chance of gallstones)

63

Desmolase MOA

breaks C-C bonds, plays a role in respiration and fermentation

64

Esophageal ulcerations in immunocompromised pt is caused by

CMV

65

Polyuria that resolves w/ Vasopressin

Central Diabetes Insipidus

66

Red urine in the morning

Paroxysmal Nocturnal Hemoglobinuria

67

HTN + hypokalemia + metabolic acidosis

Hyperaldosteronism

68

Fever + night sweats + weight loss

TB, Lymphoma

69

nystagmus + scanning speech + intention tremor

Multiple Sclerosis

70

vWF MOA

binds exposed collagen to GpIb on platelets

71

Platelet activation results in secretion of

ADP, PDGF, fibrinogen, serotonin, lysosomal enzymes, TBXA2, Ca2+, thrombin

72

Gp2b/3a MOA

platelets after activation -> binds fibrinogen

73

ITP MOA

Ab to Gp2b/3a -> destruction of platelets

74

ITP Tx

Steroids, IVIG, splenectomy

75

ITP Sx

microhemorrhages, nose bleeds, petechiae, inc bleeding time

76

TTP MOA

def in ADAMTS13 -> platelet aggregation -> thrombosis

77

Muscle cramps + dark urine following exercise

McArdle Disease

78

ADAMTS13 def

TTP: widespread thrombosis d/t vWF -> thrombocytopenia

79

Glanzman Thrombasthenia - defective

Gp2b/3a -> abnormal platelet aggregation -> inc bleeding time

80

vWF Disease - MOA

defective vWF -> inc bleeding time & prolonged PTT

81

vWF Tx

Desmopressin (DDAVP)

82

Bernard-Soulier Disease - defective ?

Gp1b -> inability to bind platelets to vWF on collagen

83

Bernard-Soulier Disease - Sx

inc bleeding time, enlarged platelets

84

DIC

widespread activation of clotting, inc bleeding time, PT, PTT, D-dimer, & low platelets & fibrin

85

Triad of HUS Sx

Hemolysis, renal insufficiency, thrombocytopenia

86

Pentad of TTP Sx

Hemolysis, renal insufficiency, thrombocytopenia, Neuro Sx, Fever

87

DIC causes

obstetric complication, trauma, sepsis, pancreatitis, malignancy, tranfusion

88

Fructose Intolerance - deficiency of

Aldolase B

89

Essential Fructosuria - deficiency of

Fructokinase

90

Classic Galactosemia - deficiency of

Galactose-1-phosphate UDP