L14: Adaptive Recognitionn

Question 1

Which cells make up the adaptive immunity

Answer 1

T cells

B cells

Question 2

What are the receptors of T cells called

Answer 2

T cell receptor

Question 3

What are the receptors of the B cells called

Answer 3

B cell receptor

Question 4

What 2 chains are the B cell receptors made of

Answer 4

Heavy

Light

Question 5

What are the types of light chain in B cell receptors

Answer 5

Kappa

Lambda

Question 6

What are the 2 regions in a B cell receptor

Answer 6

Fab domain

Fc domain

Question 7

Which domain is variable

Answer 7

Fab domain

Question 8

What is the fab domain made of

Answer 8

Heavy chain

Light chain

Question 9

What is the fc domain made of

Answer 9

Heavy chain

Question 10

What bond joins the heavy and light chains together in the B cell receptors

Answer 10

Disulphide bonds

Question 11

In the B cell and T cell receptors where does the antigen bind to

Answer 11

Antigen binding site

Question 12

How many antigen binding sites are there in the T cell receptor

Answer 12

1

Question 13

How many antigen binding sites are there in the B cell receptor

Answer 13

2

Question 14

What chains are present in the T cell receptor

Answer 14

Alpha (similar to light chain in BCR)

Beta (similar to heavy chain in BCR)

Question 15

What gene segments do heavy chains have

Answer 15

V
D
J
C

Question 16

What gene segments do light chains have

Answer 16

V
J
C

Question 17

What gene segments do alpha chain have

Answer 17

V
J
C

Question 18

What gene segments do beta chains have

Answer 18

V
J
D
C

Question 19

On what chromosome is light chains expressed on

Answer 19

Chromosome 22 and 2

Question 20

On what chromosome is heavy chain expressed on

Answer 20

14

Question 21

On what chromosome is TCR alpha chains expressed on

Answer 21

14

Question 22

On what chain is TCR beta chain expressed on

Answer 22

7

Question 23

For B cell receptors which chain is rearranged first

Answer 23

Heavy chain then light chain

Question 24

On T cell receptors which chain is rearranged first

Answer 24

Beta chain then alpha chain

Question 25

Which enzyme carries out gene rearrangement

Answer 25

RAG

Question 26

Which enzyme does point mutations

Answer 26

TdT enzyme

Question 27

Which receptor can become secreted

Answer 27

B cell receptor

Question 28

When B cell receptor is secreted what is it known as

Answer 28

Immunoglobulin/antibody

Question 29

Can B cell receptors recognise the pathogen/antigen directly

Answer 29

Yes

Question 30

Can T cell receptors recognise the pathogen/antigen directly

Answer 30

No

Question 31

If the T cell receptors cannot recognise the antigen/pathogen directly what binds to the antigen binding site of it

Answer 31

MHC

Question 32

What are the classes of MHC

Answer 32

Class 1 | Class 2

Question 33

Which T cell does MHC class 1 bind to

Answer 33

CD8 T cells

Question 34

Which T cells does MHC class 2 bind to

Answer 34

CD4 T cell

Question 35

What type of protein does MHC class 1 present

Answer 35

Endogenous

Question 36

What type of protein does MHC class 2 present

Answer 36

Exogenous

Question 37

Which cells express MHC class 1

Answer 37

Every cell apart from RBC

Question 38

Which cells can express MHC class 2

Answer 38

Lymphoid cells