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Flashcards in L55 Deck (23):
1

What bug causes syphilis?

Treponema pallidum

2

What are the 4 stages of disease for treponema pallidum?

Primary
Secondary
Tertiary
Congenital syphilis

3

Symptoms of 1ary syphilis

Chancre = painless ulcer on genitals

4

Symptoms of 2ary syphilis

"Flu"
Swollen lymph nodes
Spotted rash all over body (including palms & soles)

5

Symptoms of late syphilis

Chronic inflam + granulomatous lesions
CNS involvement = neurosyphilis
BV involvement = cardiovascular syphilis

6

How do you diagnose syphilis?

SEROLOGY
1st = RPR/VDRL
Follow up if + = FTA-ABS

7

What kind of serology test are RPR, VDRL? What info do these diagnostics give you?

Non-treponemal aka non-specific tests
Used to rule out syphilis - high FPs

8

What kind of serology test is FTA-ABS?

Treponemal = specific tests

9

Treat syphilis

Penicillin
Could use doxy

10

Treat neurosyphilis

Ceftriaxone

11

What bug causes Lyme disease

Borrelia burgdorferi

12

How would you stain for borrelia?

Giema stain (silver)

13

Lyme transmission

Ixodes ticks on deer or mice
Transmission requires prolonged feeding (24 hrs)

14

3 stages of Lyme disease

Early, localized
Early, disseminated
Late, disseminated

15

Symptoms of early, localized Lyme

Erythema migrans

16

Symptoms of early, disseminated Lyme

Timeframe = 3-5 wks post bite
1. CN7 palsy (has forehead involvement) - 1 sided facial palsy
2. Meningitis
3. Cardiac dysfxn (reversible, heart block)

17

Symptoms of late, disseminated Lyme

Arthritis

18

Diagnose borrelia burgdorferi

If see erythema migrans - that's enough!
Otherwise ELISA confirmed w/ Western blot

19

Treat Lyme - 1st & 2nd choices

Doxy
2nd choice = ceftriaxone

20

Which bug is transmitted in contaminated water via skin cuts?

Leptospira
Chronically infects kidneys of animals - pee bug into waters

21

What are symptoms of Leptospirosis?

BIPHASIC
1. Septicemic - acute, eye symptoms
2. Immune - 1 mo after, liver + kidney failure

22

Treat leptospirosis

Supportive
Penicillin or doxy

23

What is the common drug that could work for spirochetes?

Doxy!!