Flashcards in L61 Deck (19)
What 2 bugs cause mucormycosis?
What infections are the result of mucormycosis?
Walk through the pathogenesis of rhinocerebral zygomycosis
Inhale mucor/rhizopus spores
1st infection @ sinuses
Invade BVs --> necrosis
Direction access to brain
Describe the shape of fungi for mucormycosis
Branch at right angles
What is the clinical presentation of mucormycosis
Sinus symptoms + necrotic lesions
- Ethmoid sinus involvement
Pulmonary = pulmonary mucormycosis
What are you look for on CT and histo for pulmonary mucormycosis
Histo = coag necrosis
CT = dense infarction w/ halo
Surgical debridement of necrotic areas
What bug causes cryptococcosis
What are the 3 symptoms of a cryptococcal opportunistic infection?
Specifically, which IC pts are at highest risk for a cryptococcal infection?
T cell compromised
- On steroids
Explain cryptococcal pathogenesis
Replicate in lung
Progressive infection b/c IC
Spread and cross BBB
Further replication in gelatinous lesion
What is a characteristic VF for cryptococcal neoformans
HUGE capsule - doesn't stain well for this reason
What stains do you use for cryptococcus? How do they look on stain?
- Stain LIGHT
- Huge halo around nucleus b/c of capsule
Which enzyme helps with melanin production for cryptococcus?
Make melanin b/c inhibits O2 killing by host
Start: amphotericin B + 5 FC
(Just to get infection under control b/c nephrotoxic)
What bug causes pneumocytosis?
Pna: fever, dyspnea, hypoxia, non-productive cough
What do you see on histo and radiology for pneumocystis pna?
Diffuse infiltrates on CXR
Histo: occluded capillaries