Flashcards in L60 Deck (20):
Which 3 fungi should you be thinking about for opportunistic mycoses due to altered T cell fxn?
1. MUCOCUT candidasis
What are the 3 AIDs defining illnesses?
What 3 fungi should you be thinking about for opportunistic mycoses due to altered phagocytic activity?
Why must you be immune compromised to get a candida infection?
B/c part of normal flora otherwise!
What are some examples of mucocutaneous candidasis infections? (Aka these are how you should be thinking of these infections presenting in the ED)
Who are some patients that would develop mucocutaneous candidasis?
Those w/ defective T cells:
- Corticoidsteroids (inhaler)
- Women on birth control
What are some examples of systemic/deep candida infections?
Which patients are at risk for systemic candida infections?
+ Catheter to ICU pt
What will you see on scraping sample for candida infections?
What inherited condition would present with skin candida infections?
APECED - recessive
- Ectodermal dystrophy
Treat mucocutaneous candidiasis
Severe: PO fluconazole
Treat systemic candidiasis
Echinocandins - big guns!!
Surface receptors = adhesion
Dimorphism - opposite of usual!
What toxin does aspergillus produce? Why is this so concerning?
Where in the environment would you find aspergillus/its toxin?
Peanut or grain plants
Talk through the pathogenesis of aspergillosis invasion and infection in the LUNG
Impaired immune host - alveolar macrophages don't kill the inhaled fungus
Hyphae invade lung parenchyma
Angioinvasion b/c defective neutrophils
May or may not spread throughout vasculature
Shape and classification of aspergillus
What is the difference between the pathogenesis for aspergillus infection in neurtopenic vs immune suppressed patients?
- Coag necrosis
- Dissemination (nothing to fight it leaving site of infection)
- Inflam necrosis
- Local invasion
What are the 2 lung lesions you might see with aspergillus infection?