last minute path 2 Flashcards by Natalie Slaughter

what are the instristic factors

TENET

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what is common in sasknazi jews

hemophilia c

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ADP

upregulates GpIIb/IIIa on the surface of the cell

drives aggregation

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antithrombin 3

inactivates thrombin and factor X. potentiated by herparin

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function of prostacyclin and NO

inhibit platelet aggrestion

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thrombomodulin

converts thrombin to an anticoagulant

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what does vWF link subendothelium to

glycoprotin Ib receptors

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how does fibrinogen link platelets

via GpIIb - IIIa

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PT is

extrinsic

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PT is porlonged by

warfarin

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PTT is

intristic

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PTT is prolonged by

heparin

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protein C

inhibts cofactors Va and VILLLA

decreases rate of clot formation

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plasmin

breaks down fibirn

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tissue pathway factor inhibitor

inhibits VIIa tissue factor complex

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how is heparin given

IV or injuection

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what does heparin bind to

antithrombin 3

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what does heparin inhibit

thrombin factor IXa and factor Xa

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dagigatran

direct thrombin inhibitom

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ribaroxaban and apixaban

direct factor Xa inhibitor

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risk factor for herparin induced thrombocytopenia

postop immobiliation

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what can pts with extensive venous thrombosis develop

limb gangrene

secondary skin ulceration

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bernard soulier diseaes

defect of platelet adhesion

affects glycoprotien Ib

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glanzmass’ thromboasthenia

defect in platlet aggregation

glycoporon IIb/IIa

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TTP

antibodies directed againt vWF cleae proteuse

multiple DVTs is a sign of

factor V

in a car accident what is the most common DIC

thrombine activation

mix nonclotting blood with normal blood and you clot that mean

you are missing a factor

mix nonclotting blood with normal blood and you don't clot what does that mean

missing inhibitor

most common cause of hypercoagulative state

factor v

venous thrombi are most oftenc casued by

stasis

aterial thrombi most often caused by

injury

line of zane

seen with AAA | help distinguish between pre and post mortum

virchow's triad

hypercoagulable statae endothelial injury circulatory stasis

what does antiphospolipid antibody syndrome cause in vitro

inhibit clotting

what does antiphospholipid antibody do in vivo

hypercoagulable state

what is antiphospholipid antibody syndrome assocaited with

lupus false postiive for syphlis miscarriages

risk factos for venous thrombosis

``` CHF trauma surgery prengnacy cancer ```

5 unifiying feature of shock

``` increased Ca++ incrased H+ increased edema catabolic metabolism infalmmation ```

3 signs of nonprogressive phase

tachycardia peripheral vasoconstriction renal conservation of fluid

sign of progressive stage

widepread hypoxia lactic acidosis decreased urinary output

signs of irreversible stgae

lysosomal enzyme leakage

class I hemorrage shock % of blodo lost

<15

class II hemorrhagic shock % of blood lost

15-30

class III hemorrhagic shock % of blood lost

30-40

class IV hemorrhagic shock % of blood lost

>40

peutz-jergers syndrome

autosomal dominate | develop benign polps in GI tract and hyperpigmented macules

attachment to matrix compoent uses what

laminin/laminin receptor

degradation of ECM uses what

collagenases

migration of tumor cells uses what

fibronetin | motility factor

osteoblastic metatsis is most comply

prostate cancer

increased serum alk phos mean swhat

osteoblastic metasstasis

what does osteolytic metasis look like on xray

lucencies

what does BrdE do

help with grading of tumros

what are the grades of tumors

I-IV from well differentied to nearly anaplastic

How many sizes of tumors are there

what are the stages of nodal involement

0-2

what are the stages of metasis

0-2

what is the TNM system of staging

size of tumor nodal involvment distant metastases

what does dukes system check

colorectal cancer

what does ann arbor system check for

hodgkin and non hodkin lymphoma

what cancer does KRAS casue

pancrease, colon, lung

what cancer does beta catenin cause

hepatoblastoma | hepatocellualr carcimoa

what cancer does n myc casue

neuroblastoma | small cell CA of lung

what cancer does cyclin D cause

mantle cell lyphoma brest esophageal

what causes translocatino between 9-22

c-abl | chronic myelogenous leukima

what can you use to treat CML

imatinbi mesylate (gllevec)

translocation for follicular lyphoma

14-18

APC causes what

FAP

cancers of p53

lung colon breat li fraumeni

beta naphthylamin can cause

bladder cancer

nitrosamines and amines can cause

gastric carcinoma

estrogen promotes what cancers

breast squamous cell carcinoma of cervix leiomyoma of uterus

AFP detects waht

hepatocellualr carcinomas | germ cell tumors of tests or ovary

beta HCG is a marker for what

trophoblastic tumors

CEA is a marker for waht

CA colon pancrease stomach breast

last minute path 2 Flashcards

(76 cards)