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Fungal/Virology > LEC 10 - Papilloma + Pox Virus > Flashcards

LEC 10 - Papilloma + Pox Virus Flashcards

(67 cards)

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1
Q

With ocular nasal discharge + skin lesions what would be important to sample from?

A

Lesions Lymph nodes Spleen

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2
Q

What tests should be ran with a animal that has ocularnasal discharge and skin lesions?

A

C/S

VI
EM

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3
Q

What are the differientials in an animals that has skin lesions + oculonasal discharge?

A

Tularemia

Plague

Herpes virus

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4
Q

What is the target when trying to make a conclusive diagnosis about which orthovirus an animal has?

A

Conserved/Degenerate PCR

Target: Hemagglutinin gene

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5
Q

What is the reservior for monkeypox?

A

Rodents

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6
Q

What diseases are under capripoxviruses?

A

Sheep/goat pox

Lumpy skin disease

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7
Q

What diseases are under leporioxivirus?

A

Rabbit Myxoma virus

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8
Q

Types of diseases: Orthopoxvirus

A

Vaccinia

Coxpox

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9
Q

Types of diseases: Parapoxviruses

A

ORF

Bovine papular stomatitis

Pseudocowpox

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10
Q

Types of diseases: Avipoxvirus

A

Fowlpox

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11
Q

What are the reportable poxvirus diseases?

A

Sheep/goat pox

Lumpy skin disease

Rabbit Myxoma virus

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12
Q

What is the structure of the pox virus?

A

Barrel/box structure

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13
Q

What is the genome in a pox virus made of?

A

dsDNA

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14
Q

Is poxvirus enveloped or not?

A

Yes

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15
Q

How does poxviruses get into the cell?

A

Fusion/Macropincytosis

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16
Q

Where does the pox virus replicate in the host cell?

A

Cytoplasm

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17
Q

What is the sequence of events in the poxvirus infection?

A

Fusion/macropinocytosis

Uncoating + early protein synthesis

Intermediate gene expression + DNA replication in cytoplasm

Late phase gene expression = structural proteins

Viral assembly

Virion

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18
Q

What types of virions do pox viruses make?

A

Intracellular mature virion

External enveloped virion

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19
Q

What does the intracellular mature pox virion do to the cell?

A

Lyse the cell no envelope

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20
Q

What are does the external enveloped virion do to the host cell?

A

Budding so does not harm the host cell immediately

May lyse later one

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21
Q

What is the incubation period for the pox virus?

A

3 to 5 days

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22
Q

What are the clinical signs of the pox virus?

A

Skin lesions - vesicles + scabbing

Lesions variably located

Mortality rare but can occur

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23
Q

How does immunity occur to the pox virus?

A

IFN - directed

Complement cascade

CTL-mediated

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24
Q

How does the pox virus evade the immune system?

A

Stealth + Mimicry

MHC I + CD4 down regulation + depletion

IFN + TNF receptor homologs

IL-10 homologs

Complement system disruption

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25
What does poxvirus cause in bovine?
Bovine papular stomatitis
26
What is important to remember when working with a possible BVS case?
Zoonotic potential
27
What is the disease course of bovine papular stomatitis?
3 weeks
28
What is the major clinical signs of bovine papular stomatitis?
Oronasal lesions
29
What are the clinical signs of orf/contagious ecthyma?
Oronasal lesions
30
How long does it take for contagious ecthyma to run its course/
3 weeks
31
What is important to remember when working with Contagious ecthyma?
Zoonotic
32
What body systems are targeted with sheep/goatpox?
Dermal Pulmonary
33
What type of prevention is avalible for sheep/goatpox?
MLV Subunit vaccines
34
What is the mortality rate with sheep/goatpox?
Greater than 50$
35
What is the target in lump skin disease?
Endothelium
36
What is the problem with lumpy skin disease?
\> 5% mortality But great economic loss due to decrease in weight
37
What type of prevention is used in lumpy skin disease?
MLV, subunit vaccines
38
What animals are most affected by myxomatosis?
Oryctolagus rabbits (European) Sylvilagus rabbits ( Cottontails + Jack rabbits) not killed by the virus
39
What cells are targeted in Myxomatosis?
Lymphocytes
40
What protection is avalible for myxomatosis?
MLV, non-lethal analog virus
41
What is the mortality rate with myxomatosis?
25 to 99%
42
How are pox viruses transmitted?
Aerosol Vector Direct contact Fomites
43
What is the treatment for poxvirus infection?
Palliative
44
What are the differientials for dermal neoplasias in a horse?
Equine sarcoid Squamous cell carcinoma Granulomas Solar dermatitis
45
What is seen upon histology of a dermal neoplasia that is due to equine sarcoids?
Spindle cells in interlacing bundles + whorls Collagenous matrix Low-moderarte mitotic rate
46
What causes equine sarcoids?
Non-conforming bovine papillomavirus (BPV-2) infection
47
What is the structure of the papilloma virus?
Icosahedral structure
48
What is the structure of the genome in the papillomavirus?
dsDNA
49
How does the papillomavirus enter the host cell?
Endocytosis
50
Where does the papillomavirus replicate?
Nucleus
51
What is the sequence of the papillomavirus replication?
Endocytosis Transport to nucleus Early protein transcription/translation Late protein transcription/translation +/- host chromosome integration
52
What cell type is the papillomavirus endocytosed within?
Basal squamous epithelial cells
53
What are the clinical signs of papillomavirus?
Proliferative lesions (warts) of the epithelium Dermis, oral/gastric mucosas, bladder
54
What is the major characteristic of the life cycle of a papillomavirus?
Lengthy + Variable incubation period
55
How does the host immune system handle the papillomavirus?
Primarily cell mediated Since doesn't go in the blood rely on peripheral immune system
56
How does the papilloma virus avoid the immune system?
Stealth - no viremia + non-cytolytic IFN pathway inhibition
57
What is the treatment for a papillomavirus infection?
Excision Cryosurgery Radiation + Chemotherapy
58
What can happen in dogs with a papillomavirus infection?
Spontaneous regression
59
What is the structure of the genome of african swine fever?
dsDNA
60
What is the structure of the african swine fever virus?
Icosahedral, non-enveloped
61
What is special about the african swine fever virus?
Only known DNA cirus with an arthropod vector (TICKS)
62
How does african swine fever virus enter the host cell?
Viral endocytosis
63
Where does the african swine fever virus replicate in the host cell?
Cytoplasm
64
What is the sequence of events when it comes to the african swine fever virus?
Early gene trasncription + genome replication Late gene trasncription (structural proteins) Packaging + membrane budding
65
What are the peracute signs of african swine fever?
Sudden death
66
What are the acute signs of african swine fever?
Fever + ADR + Cutaneous hemorrhage High mortality
67
What are the subacute symptoms of african swine fever?
Pneumonia Weight loss Joint swelling ADR Variable mortality

Fungal/Virology (26 decks)

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