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Fungal/Virology > LEC 18 - Distemper + PI3 > Flashcards

LEC 18 - Distemper + PI3 Flashcards

1
Q

What is seen upon PE in a dog with distemper?

A

Blepharendema + blepharitis

Preputial edema

Fever

Enlarged LN

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2
Q

What is the diagnostic plan for a dog with distemper?

A

CBC

Chemistry panel

U/A

LN aspirattion

Chest rads

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3
Q

What is seen increased on a CBC in a dog with distemper?

A

INcrease Neutrophils

Increased monocytes

Increased nucleated cells

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4
Q

What is the general thing seen upon cytology of a dog with distemper?

A

Supprative inflammation

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5
Q

What are the differential diagnosis for a dog with distemper?

A

Autoimmune

Infectious - Staph + Pseudomonas

Leshmania

Rickettsia

Idiopathic

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6
Q

What testing can be done for distemper?

A

Swab

Serology

Culture/Sensitivity

Anti-nuclear testing (Autoimmune)

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7
Q

What is the genomic structure of CDV?

A

ssRNA (-)

Enveloped

No segments

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8
Q

What does it mean when an ssRNA virus is not segmented?

A

No recombination can occur

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9
Q

Where does CDV replicate in the cell?

A

Cytoplasm

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10
Q

What are the other distempers in the environment?

A

Measles

Rinderpest

Phocine distemper virus

Cetacean morbilliviurs

Nipah virus

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11
Q

What species are infected by CDV?

A

Canidae

Felidae

Ursidae

Mustilidae

Procyonidae

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12
Q

What is seen in big cats with CDV infections?

A

Grand mal seizures

Myoclonus

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13
Q

How is it thought that CDV was introduced into the serengeti?

A

Via Domestic dogs

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14
Q

Where does CDV enter the body?

A

Respiratory epithelieum

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15
Q

Where does initial CDV replication occur?

A

Epithelial Macrophages

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16
Q

How does CDV move throughout the body?

A

Migrate to draining LN

Primary viremia

Secondary viremia

CNS penetration

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17
Q

What occurs with primary viremia in CDV?

A

Replication in lymph organs

Fever

Lymphopenia

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18
Q

What occurs with secondary viremia in CDV?

A

Disseminates to epithelial tissues

GI + UT + Respiratory

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19
Q

Where does CDV tend to infect in the brain?

A

Grey matter

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20
Q

How does CDV shed?

A

In all body secretions

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21
Q

Where does CDV persist in the body?

A

Uveal tissues

Neurons

INtegument

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22
Q

What is seen with CDV upper respiratory infections?

A

Mucopurulent discharge

Dry/productive cough

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23
Q

What is seen with lower respiratory tract infections with CDV?

A

Interstital lung pattern - early on

alveolar with secondary bronchopneumonia - late

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24
Q

What symptoms are seen when grey matter is infected with CDV?

A

Seizures

Stupor

Atazia

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25
What symptoms are seen when the white matter is infected wioth CDV?
Multifocal, cerebellar-vestibular ataxia UMN/GP signs
26
What are the clincal signs seen with CDV that are not respiratory or neuro?
Enamel hypoplasia Hypertrophic keratropathy Metaphyseal osteosclerosis
27
What is seen grossly with a CDV infection?
Thymic atrophy Bronchopneumonia ENteritis Lymphoid necrosis Intersitial pneumonia
28
What is seen histologically with CDV infection?
Both cytoplasmic/IN inclusion bodies Esoinophilic
29
What is the tranimission route of CDV?
Aerosol - body fluids (respiratory + urine) Fecal/oral
30
What are the clincal signs in puppies that were infected with CDV transplacentally?
Enamel hypoplasia Cardiomyopathy Increased risk of CNS
31
How long does it take to see signs if a puppy was infected with CDV transplacentally?
4 to 6 weeks of age
32
What happens in old dogs that have been previously infected with CDV?
Old Dog Encephalitis
33
What five tests can be done to test for CDV?
FA rt-PCR Blood smear Antibody tests Virus isolation
34
When is viral isolation good to use for CDV diagnosis?
Neonates, Determines vaccinal vs. natural infection
35
Which CDV test is the most sensitive?
rt-PCR
36
Which CDV test is the go to test first?
FA
37
What cell types are inclusion bodies seen in?
Macrophages RBC's
38
What does CDV FA testing require?
Active infection
39
What is used for a CDV FA?
Conjunctival swab Preputial swab Impression of - Brain + Bladder + Lung + Footpad
40
What is required for rt-PCR CDV test?
Presence of viral particle
41
What can be used for a CDV rt-PCR?
Tissue - fresh or frozen Whole blood + CSF + Urine
42
What is the treatment for CDV?
Supprotive Treat secondary bacterial ifnections
43
What is seen upon necropsy in cattle with respiratory disease complex?
Severe Crainial ventral pneumonia Affected tissue is firm Minor fibrin deposits
44
What are the four most common viruses in the respiratory disease complex?
BVDV PI3 BRSV IBR
45
How do the majority of PI3 cases present?
Subclinical
46
What is the pathogenesis of PI3?
Infection of ciliated epi cells + Alveolar cells + Macrophages Loss of muciliary apparatus Secondary bacterial infections
47
What is the pathogensis of BRSV?
Replication in ciliated epi Necrotizing bronchiolitis Host response enhances pathology Persistant infection
48
What is seen upon histological examination of BRSV?
Syncytial formation in type 2 pneumocytes
49
What is the method of prevention in PI3 + BRSV?
Address the environmental + stress concerns Identify disease Vaccines
50
What is the homolog to BRDC in small animals?
Kennel cough
51
What are the differientials for kennel cough?
Bordetella bronchiseptica Mycoplasma Canine adenovirus Canine parainfluenza
52
How is canine parainfluenza diagnosed?
Clincal history
53
What is the treatment for canine parainfluenza?
Palliative Symptomatic
54
What is the respiratory disease in chickens?
Newcastle disease virus
55
What symptoms are seen with new castle disease?
Acute respiratory disease CNS signs Diarrhea
56
What are the three virulent groups of Newcastle?
Virulent Moderately Low
57
Describe Moderately virulent newcastle
Mesogenic
58
Describe virulent newcastle
Velogenic
59
Describe low viruent Newcastle
Lentogenic
60
What is seen upon necropsy of an animal with Newcastle?
Petichiae or hemorrhage +/- necrosis Thymic edema Respiratory congestion + mucoid exudates

Fungal/Virology (26 decks)

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