LEC 12 - Herpesvirus II + Adenovirus Flashcards by Raegan Chambers

What does suid herpesvirus 1 cuase?

Aujeszky’s disease

How well did you know this?

Not at all

Perfectly

What animals does SHV-1 infect?

Pigs

Horse + Cattle + Sheep + Dogs + Cats + Wild animals

How well did you know this?

Not at all

Perfectly

What is the mechanism of transmission for SHV-1?

Nose-to-nose contact

Saliva, nasal discharge

Airborne routes

How well did you know this?

Not at all

Perfectly

Who are reservoirs for SHV-1?

Domestic + Feral swine

How well did you know this?

Not at all

Perfectly

Where in the body does SHV-1 first replicate?

Oropharynx

How well did you know this?

Not at all

Perfectly

Once SHV-1 has replicated in the oropharynx, where does it spread?

CNS

Leads to ganglioneuritis

How well did you know this?

Not at all

Perfectly

What does SHV-1 cause in secondary hosts?

Pruritis

How well did you know this?

Not at all

Perfectly

What does SHV-1 cuase in pregnant sows?

Abortion

How well did you know this?

Not at all

Perfectly

What does SHV-1 cause in piglets?

High mortality

How well did you know this?

Not at all

Perfectly

What does SHV-1 cause in older pigs?

Low mortality

High morbidity

How well did you know this?

Not at all

Perfectly

What type of diease is SHV-1 considered by the US?

Exotic disease

How well did you know this?

Not at all

Perfectly

How is control carried out to prevent a SHV-1 outbreak?

Quarantine

Add only seronegative stock

Exclude secondary host animals

All in/All out production system - with disinfection

How well did you know this?

Not at all

Perfectly

What does porcine cytomegalovirus cuase in pregnant sows?

Delivery of dead, mummified or weak piglets

How well did you know this?

Not at all

Perfectly

How can PCMV be diagnosed?

ELISA of serum

How well did you know this?

Not at all

Perfectly

What are good ways to control a PCMV outbreak?

Good environmental conditions

Minimize stress

Acclimate new breeding stock to herd

How well did you know this?

Not at all

Perfectly

What does FHV-1 cause in cats?

Upper respiratory tract infection

Feline rhinotracheitis

How well did you know this?

Not at all

Perfectly

What are the symptoms of Feline rhinotracheitis?

Sneezing

Coughing

Fever

Porfuse Nasal/ocular discharge

Keratitis

Anorexia

Weight loss

How well did you know this?

Not at all

Perfectly

When is it most common to see a FHV-1 infection?

First year of life

How well did you know this?

Not at all

Perfectly

What does a FHV-1 infection resemble?

Feline calicivirus

How well did you know this?

Not at all

Perfectly

What is the mechanism of transmission with FHV-1?

Direct contact

Fomites

How well did you know this?

Not at all

Perfectly

What medication can cause FHV-1 to reactivate?

Steroid therapy

How well did you know this?

Not at all

Perfectly

How can FHV-1 be diagnosed?

ELISA

PCR

Immunofluorescent staining

How well did you know this?

Not at all

Perfectly

Why must you be careful in interupting FHV-1 postiive PCRS?

Test is very sensitive

Subject ot confounding by low level virus release in clinical latency

How well did you know this?

Not at all

Perfectly

What can help increase your cofidence in a positive PCR test?

high virus levels in nasal secretions or tears

with clinical signs

How well did you know this?

Not at all

Perfectly

What does CHV-1 cause in puppies?

Generalized hemorrhagic disease

How is CHV-1 transmitted?

STI

Where does the CHV-1 replicate best in the body?

Places with low temperatures Gential + Upper respiratory tracts

What does a necropsy reveal in a dog that has died of CHV-1?

Fluid infiltration into lungs + abdomen Hemorrhage in kidneys + liver + lungs

What is the CHV-1 therapy?

Supportive

What is the genomic structure of adenoviruses?

Dna

What cell type does adenoviruses prefer?

Epithelial cells

What types of infections does adenoviruses cause?

Lytic Latent Persistent

What is the structure of adenoviruses?

Non-enveloped Environmentally persistant Capsids ahve obvious hexagonal outline

What occurs in the early phase of adenovirus replication?

Prevent host cell apoptosis or premature death Allow DNA synthesis Activate other viral genes

What occurs in late phase replication of adenoviruses?

MLP begins expression of late genes composing of virus structure + factors needed for assembly

When does the late phase of adenovirus replication begin?

Commences after DNA replication is ready to start

What adenovirus early gene products affect host cell tumor supression genes?

E1A -- and -- E1B

What happens once E1A + E1B carry out their function?

Host is driven into unscheduled S phase to allow for DNA synthesis

What mechanism does adenovirrus cause?

Malignant transformation

What do viral E3 proteins do?

Inhibit MHC antigen transport Block TNF receptor internalization Inhibit NFkB transcription activity

What happens when E3 proteins inhibit MHC antigen transport?

Prevent infected cells from being recognized by cutotoxic T cells and natural killer cells

What happens when E3 proteins block TNF receptor internalization?

Halts apoptosis signaling

What happens when E3 protein inhibits NFkB transcription?

Decreases inflammatory response

What does canine adenovirus 1 cause?

Infectious canine hepatitis possibly - respiratory or eye diease

What are the three clincal syndromes seen with CAV-1?

Peracute Acute Mild form

What happens with the peracute form of CAV-1?

Death after no or very short illness

What occurs with the acute form of CAV-1?

Fever Vomiting Bloody diarrhea Petechial hemorrhage of gums Pale, mucous membranes Jaundice

What are the clincal symtoms of CAV-1 ?

Fever Apathy Anorexia Conjunctivitis Petechiae of oral mucosa Prolonged clotting time Corneal opacity after acute disease remission

What routes does the intial infection occur by?

Nasopharyngeal Oral/Conjunctival routes

Where does the inital replication of CAV-1 occur in the body?

Tonsils Lymphatic spread then to blood stream

What happens once CAV-1 becomes viremic?

Extensive destruction of hepatocytes in liver disease

Who does CAV-1 most infect?

Young dogs Un-vaccinated animals

How does the CAV-1 virus spread?

Saliva Feces Urine Fomites

How is CAV-1 diagnosed?

Virus isolation Serology by ELISA PCR

Where can the CAV-1 virus be isolated from even after symptoms go away?

Urine

What is a good retrospective sign of a past CAV-1 infection?

Blue cornea

What does CAV-2 cause?

Canine cough complex Confined to respiratory tract - bronchitis + bronchiolitis

What vaccine is used to protect against CAV?

CAV-2 there is cross reaction and it will also protect against CAV-1

Why is it best not to use a vaccine with attenuated CAV-1?

Produce corneal bluing response

What is seen with the egg drop syndrome?

Soft-shelled eggs -- or -- Completely shell-less eggs

What causes egg drop syndrome?

Duck adenovirus 1

What caused chickens to become infected with DAV-1?

Contaminated vaccine produced in duck cells

What chickens are susceptible to a DAV-1 infection?

All ages + breeds

What are the three patterns of infection of DAV-1?

Classical Endemic Sporadic

Describe: Classical DAV-1 infection

Primary breeding stock infected Virus passed through egg Remains latent until bird reaches sexual maturity

Describe: Endemic DAV-1 infection

Horizontal infection of flock during lay Commercial operations

Describe: Sporadic CAV-1 infections

Contact with ducks or geese OR Water contaminated with wildfowl droppings

What is the first sign of DAV-1 infection?

Pale eggs with soft shell Production decreases by up to 40%

What assay can be done to detect DAV-1?

Hemagglutinating acitivity

How can the virus be transmitted through the flock?

Bleeding or vaccination needles

How does horizontal spread occur with DAV-1?

Contaminated eggs, equipment, + personnel

What is the treatment for DAV-1?

None

When are vaccines given for DAV-1?

During growing pahse inactivated vaccines

LEC 12 - Herpesvirus II + Adenovirus Flashcards

(73 cards)