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Fungal/Virology > LEC 6 - Opportunistic Fungal Infections > Flashcards

LEC 6 - Opportunistic Fungal Infections Flashcards

(49 cards)

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1
Q

What is an important step in the life cycle of Phyium insidiosum?

A

Needs to infect plants to complete cycle

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2
Q

What allows P. Insidiosum to invade animal tissue?

A

Motile zoospores w/ germ tube production

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3
Q

Affected Animals: P. Insidiosum

A 
Horses
Dogs 
Calves 
Sheep 
Cats
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4
Q

Lesions: P. Insidiosum

A

Granulomatous tissues - Subcutaneous or Intestinal

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5
Q

Infective stage: P. Insidiosum

A

Animal wades in water

Zoospore infects = oppurtunistic

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6
Q

How doe the zoospores of P. Insidiosum invade the tissue?

A

Through the germ tubes that produce aseptate hyphae

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7
Q

What does P. Insidiosum do while its disseminating?

A

Causes thrombosis

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8
Q

What causes tissue damage with P. Insidiosum infections?

A

Degranulating EOS + Mast cells

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9
Q

Where do lesions in horses tend to occur with P. Insidiosum infections?

A

Body parts that contacted the water

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10
Q

Disease: P. Insidiosum

A

Cutaneous pythiosis

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11
Q

Lession appearance: P. Insidiosum in Horse

A

Large, circular granulomatous nodules
Ulcerate
Pruritus
Necrotic yellowish coral-like mass

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12
Q

What can happen with chronic P. Insidiosum infections?

A

Bone involvement

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13
Q

Define: Enteric pythioss

A

Stenotic fibrous GI lesions

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14
Q

Target Organs: P. Insidiosum in DOgs

A

Stomach + SI

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15
Q

Clinical Signs: P. Insidiosum in Dogs

A

Vomiting
Wt. Loss
Diarrhea
PALPABLE ABDOMINAL MASS

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16
Q

What is causing the abdominal mass in a dog with a P. Insidiosum infection?

A

Extension into pancreas + bile ducts + mesenteric LN

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17
Q

Where do cutaneous lesions in dogs tend to occur with P. Insidiosum infections?

A

Base of tail
Extremities
Perineum
Ventral Neck

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18
Q

Diagnosis: P. Insidiosum

A 
Tissue stain 
Immunofluorescence 
PCR 
Culture 
Serology
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19
Q

Culture: P. Insidiosum

A

Sabouraud dex. agar

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20
Q

ID colony: P. Insidiosum

Study These Flashcards
A

Aseptate hyphae

Colorless to white w/ short aerial hyphae

21
Q

Stain: P. Insidiosum

Study These Flashcards
A

PAS + Methenamine silver

22
Q

P. Insidiosum: Treatment Dogs

Study These Flashcards
A

Aggressive surgery
Remove infected bowl
Amputate distal limbs infected
NO ERGOSTEROL IN MEMBRANE - still txt w/ Itraconazole

23
Q

P. Insidiosum: Treament Horses

Study These Flashcards
A

Wide surgical excision + Immunotherapy

24
Q

Describe: P. Insidiosum Immunotherapy

Study These Flashcards
A

Regulation of T cells from Th1 to Th2

25
Describe P. Insidiosum Thermotherapy
Apply local heat daily to lesion | Enhances intracellular killing capability of NEU
26
Morphology: Sporothrix schenickii
Dimorphic temperature dependent fungus
27
Etiology: S. Schenickii
Worldwide
28
Culture for Environmental form :S. Schenickii
SDA
29
Colony: S. Schenickii
Hyphae + Condiophores w/ rosette clusters of pear shapped conidia
30
Environmental form: S. Schenickii
25 deg | Hyphae + Condiphores
31
Infective form: S. Schenickii
37 deg | Cigar-shapped pleomorphic budding yeast cells
32
Culture for Infective form: S. Schenickii
Brain Heart Infusion Agar `
33
Clinical Signs: S. Schenickii = Horse/Dogs
Cutaneous/Lymphocytaneous form
34
Clincal Signs: S. Schenickii = Cats
Lymphocutaneous | Disseminated
35
Describe: Equine Sporotrichosis
Lymphocutaneous Spores enter skin abrasion Nodules develope along superficial lymphatic vessesl
36
Describe Feline Sporotrichosis
Primary nodular lesions Ulcerative with seropurulent exudate Extends to lymphatics
37
Areas of infection: S. Schenickii - Felines
Limb extermities Head Tail
38
Area most infected with S. Schenickii in cats
Brazial
39
Describe Canine Sporotrichosis
Multiple cutaneous lesions Ulcerated + Crusted + Alopecic Occasional lymphocutaneous involvement
40
Treatement: S. Schenickii Horse
Systemic Isodid preparation Organic perferred (EDDI) Feed additive
41
Treatment: S. Schenickii - Dogs/Cats
Itraconazole
42
Infection form: P. Carinii
Asexual trophozoite
43
Reproducing form: P. Carinii
Sexual reproducing cyst
44
Predisposition: P. Carinii
High prevalence of young animals | Airborne/transplacental
45
Animals infected: P. Carinii
``` Dogs Horses Rabbits Cats Pigs ```
46
DOC: P. Carinii
Trimethoprim -- or -- TMS Supportive care
47
Culture: P. Carinii
CAN NOT BE
48
PCR: P. Carinii where from?
lung tissue
49
Clincal signs: P. Carinii
Diffuse Pulmonary consolidation Marked thickening alveolar space Proteinaceous exudate in alveoli

Fungal/Virology (26 decks)

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