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LAST CLASS > LEC 11 & 12 > Flashcards

LEC 11 & 12 Flashcards

1
Q

myelopoiesis is the production of what types of WBC

A

monocytes, neutrophils, eosinophils, and basophils

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2
Q

what are the 2 types of mononuclear cells

A

monocytes and lymphocytes

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3
Q

what system do lymphocytes belong to

A

immune

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4
Q

what happens when neutrophils migrate to the tissues

A

death

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5
Q

what do you call a basophil in the tissues

A

mast cells

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6
Q

T or f: you will find mast cells in circulation

A

F

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7
Q

what WBC will increase in allergic rxns

A

basophils

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8
Q

what are the 3 types of lymphocytes

A

B, T, null

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9
Q

where do you find macrophages

A

tissues

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10
Q

what myelopoiesis pool of cells can divide

A

proliferation (mitotic) pool

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11
Q

what myelopoiesis pool of cells can’t divid

A

maturation (storage) pool

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12
Q

what myelopoiesis pool of cells is depleted in exaggerated conditions

A

proliferation (mitotic) pool

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13
Q

what myelopoiesis pool of cells is only mature cells

A

maturation (storage pool)

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14
Q

what myelopoiesis pool of cells is depleted 1st in infection

A

maturation (storage) pool

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15
Q

t or f: you can ID CFU-GEMM based on morphology

A

F

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16
Q

what type of cells are neutrophils, eosinophils, basophils, monocytes, and macrophages

A

myelocytic cell

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17
Q

what type of cells are natural killer cells, B cells, and T cells

A

lymphocytic cells

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18
Q

what are the stages of the WBC (youngest to oldest)

A
  1. myeloblast
  2. promyelocyte
  3. myelocyte
  4. metamyelocyte
  5. band
  6. polymorphonuclear leukocyte
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19
Q

what cell belongs to these cells markers: CD34, Tdt, CD117, and HLA-DR

A

myeloblast

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20
Q

what condition will show all stages of WBCs in PBS

A

chronic myelogenic leukemia

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21
Q

what WBC will respond to parasitic infections and allergies

A

eosinophils

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22
Q

what is the progenitor cells of eosinophils

A

CFU-esinophil

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23
Q

what type of granules do eosinophils have

A

specific, acidophilic

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24
Q

what are in the granules of eosinophils

A

enzymes

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25
what is the normal amount of eosinophils
1-2%
26
what is the clinical significance of eosinophilpenia
none
27
t or f: eosinophils can have a segmented nucleus
t
28
what kind of WBC responds to inflammation
basophils
29
t or F: basophils' granules are water soluble
T
30
what chemical is in basophils' granules
histamine
31
what is the progenitor cell of monoblast
CFU-monocyte
32
what cell belongs to these cell markers: CD34 + and CD117 +
monoblast
33
what is a main characteristic of promonocyte nucleus
folded
34
when a monocyte goes to the tissues what is it called
macrophage
35
what is the function of a monocyte
phagocytize
36
t or f: macrophage are ag presenting cells
T
37
what does it mean if you see macrophages in the PB
damage to the tissues
38
what are the primary sites of development of lymphocytes
BM and thymus
39
what are the secondary lymphoid organs
lymph nodes and spleen
40
what are the stages of development of lymphocytes
1. lymphoblast 2. prolymphocyte 3. lymphocyte
41
what is a cytoplasmic difference between a lymphoblast and a myloblast
myloblast will have rods
42
lymphocyte reference range in children younger than 1
60-70%
43
lymphocyte reference range in children 1-4 years old
55%
44
lymphocyte reference range in adults
20-40%
45
b lymphocyte reference range
20%
46
t lymphocyte reference range
80%
47
if the CD 4 + and CD8 + ratio if off what does this indicate
HIV
48
natural killer reference range
3 to 15%
49
what WBC will increase in viral infections
lymphocytes
50
what is a characteristic feature of baby lymphocyte
halo around the nucleus
51
what is a memory cell
lymphocyte that has been exposed to Ag
52
what is a plasma cell
B cell that is differentiated
53
what kind of viral infection have reactive lymphocytes
infectious mononucleosis
54
what WBC is effected in pelger Huet anomaly
neutrophils
55
what gene will be mutated in pelger Huet anomaly
lamin B receptor gene
56
how is pelger Huet anomaly inherited
dominantly
57
T or F: neutrophils in pelger Huet anomaly will not function normally
F
58
how many segments will a homozygous pelger Huet anomaly pt have
1
59
how many segments will a heterozygous pelger Huet anomaly pt have
2
60
hereditary hyper segmentation of neutrophils is often confused with
megaloblastic anemia
61
what is the problem with gaucher and niemann-pick disease
def in enzyme that breaks down neutropolysaccrides
62
what enzyme is def in gaucher disease
beta-glucocerebrosidase
63
what enzyme is def in niemann-pick disease
acid sphingomyelinase
64
what cell is effected in gaucher and niemann-pick disease
macrophages
65
how is alder reily anomaly inherited
autosomal recessive
66
what is the problem with alder reilly anomaly
defect in mucopolysaccharides
67
how will the mucopolysaccharides look in alder Reilly anomaly
large purple staining inclusions
68
what cells are effected in chediak-higashi syndrome
- granulocytes - monocytes - lymphocytes
69
T or F: WBC can not function in chediak-higashi syndrome
T
70
pt with chediak-higashi syndrome are at a high risk of what
infection
71
what kind of disorder is may hagglin anolmaly
plt disorder
72
what will a may hagglin anomaly PBS look like
- large plt/thrombocytopenia - dohle- like bodies in neutrophils
73
what is a common cytoplasmic finding in bacterial infections
toxic granulations
74
def? blue inclusion
dohle bodies

LAST CLASS (15 decks)

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