LEC 17

Question 1

what kind of lymphocyte is involved in CLL

Answer 1

b cells

Question 2

what kind of people get CLL

Answer 2

older

Question 3

is atypical or typical ALL more aggressive

Answer 3

atypical

Question 4

what CD marker do CLLs aberrantly express

Answer 4

CD5

Question 5

what CLL diagnosis has a score of more than or equal to 4

Answer 5

CLL

Question 6

what CLL diagnosis has a score of 1-2

Answer 6

non Hodgkin lymphoma

Question 7

what chromosome is deleted/mutated in CLL

Answer 7

p17 and TP53

Question 8

what is the most powerful prognostic marker of CLL

Answer 8

IGHv

Question 9

diagnosis:
- very high lymph count (could be both T and B cells)
- high WBC count

Answer 9

prolymphocytic leukemia

Question 10

T or F: B cell prolymphoctyic leukemia has 1 prominent nucleolus

Answer 10

T

Question 11

T or F: T cell prolymphoctyic leukemia has 1 prominent nucleolus

Answer 11

F

Question 12

what chromosome is mutated in T prolymphocytic leukemia

Answer 12

inv (14)

Question 13

what kind of marker is TdT

Answer 13

immature cells

Question 14

what kind of lymphocyte is affected in hairy cell leukemia

Answer 14

B cell

Question 15

what kind of people get infected with hairy cell leukemia

Answer 15

middle aged

Question 16

what stain is used to diagnosis hairy cell leukemia

Answer 16

TRAP

Question 17

what virus is associated with adult T cell leukemia/lymphoma

Answer 17

HTLV (human t. lymph virus)

Question 18

diagnosis?
- clumped “flower” chromatin
- deeply basophilic cytoplasm

Answer 18

adult t. cell leukemia/lymphoma

Question 19

what kind of lymph is affected in burkitt leukemia/lymphoma

Answer 19

b cell

Question 20

what kind of burkitt leukemia/lymphoma is EBV-related, African children, extra-nodal involvement

Answer 20

endemic

Question 21

what kind of burkitt leukemia/lymphoma is mostly abdominal, extra-nodal involvement

Answer 21

sporadic

Question 22

what kind of burkitt leukemia/lymphoma is profound immunosuppression, blood and BM primary sites

Answer 22

HIV related

Question 23

diagnosis:
- b lymphs are medium size, deeply basophilic cytoplasm, vacuoles “starry sky”

Answer 23

burkitt leukemia/lymphoma

Question 24

what is the most familiar form of cutaneous T cell lymphoma

Answer 24

mycosis fungoides/ sezary syndrome

Question 25

who does mycosis fungoides/ sezary syndrome affect

Answer 25

eldery

Question 26

diagnosis: - affect t cells - cerebriform nuclei - nucleoli not obvious - dense chromatin

Answer 26

mycosis fungoides/ sezary syndrome

Question 27

what organ does Hodgkin lymphoma affect

Answer 27

lymph nodes

Question 28

what are the 2 forms of Hodgkin lymphoma

Answer 28

classic and lymphocyte-predominant

Question 29

what form of Hodgkin lymphoma is more common

Answer 29

classic

Question 30

who is affected by Hodgkin lymphoma

Answer 30

young adults

Question 31

how is Hodgkin lymphoma (1st tumor) cured

Answer 31

combination chemotherapy.

Question 32

diagnosis: - reed-stern berg cells (bi/multinucleated) - CD15 and CD30

Answer 32

hodgkin lymphoma

Question 33

what kind of Hodgkin lymphoma has no reed-sternberg cells and is CD15 and CD30 neg

Answer 33

lymphocyte predominant

Question 34

disease? malignant disorders of terminally differentiated B cells

Answer 34

plasma cell neoplasms

Question 35

what organ do plasma cell neoplasms affect

Answer 35

BM

Question 36

what causes multiple myeloma

Answer 36

monoclonal Igs

Question 37

what plasma cell neoplasms have hypercalcemia, renal failure, anemia, and bone lesions

Answer 37

multiple myeloma

Question 38

how will RBCs look with multiple myeloma

Answer 38

rouleux

Question 39

what is the marker for multiple myeloma

Answer 39

CD138+

Question 40

what plasma cell neoplasm has high IgM and very viscous plasma

Answer 40

waldenstrom's macroglobulinemia

Question 41

how is waldenstrom's macroglobulinemia treated

Answer 41

plasmapheresis

Question 42

what gene is mutated in waldenstrom's macroglobulinemia

Answer 42

MYD88