How do animals become infected with Group A rotavirus?
What does Group A rotavirus target in the body?
What are clinical hallmarks of a Group A rotavirus infection?
When are calves susceptible to Group A rotavirus?
first week of age
When are piglets susceptible to group A rotavirus infections?
First 7 weeks of life
What secretory enterotoxin is produced by Group A rotavirus?
What is the pathogenesis of group A rotavirus infection?
Upper 2/3 of villi are affected
Necrosis of epithelium
Shortening + fusion of villi
Virus produces NSP4 increasing Cl- secretion
Blocks Na/Glu cotransporter
Malabsorptive + Secretory diarrhea
What is the pathogenesis of coronavirus enteritis?
Crypt epithelium can be hyperplastic + necrotic
Crypt abscesses form
Characterized by necrotic cellular debris dilating crypts
What animals are affected by adenoviral enteritis?
In Arabian horses what does adenovirus infections associate with?
How is adenovirus transmitted?
What cell type does adenovirus target?
What occurs to the villus with an adenovirus infection?
Villus blunting + Fusion
What are the histopathological signs of an adenovirus infection?
Basophilic to amphophilic intranuclear inclusion bodies
What animals are most affected by E. Coli?
Pigs + Calves
- What are the determining factors that determine if an e. coli infection shows disease?
What are the five forms of e. coli?
Enteropathogenic/Attaching + Effacing
Describe: Edema disease
How do all e. coli attach to cells?
-- or --
What toxins do e. coli produce?
-- and --
What age is most affected by ETEC?
2 days to 3 weeks
What animals are most commonly infected by ETEC?
What does ETEC cause?
How does ETEC cause secretory diarrhea?
Endotoxin induced Na/Cl secretion into lumen by affecting cGMP and CGAMP dependent kinase
What animals are infected by EIEC?
Newborn calves + lambs
What is the pathogenesis of EIEC?
Bacteria enter umbilicus + oral cavit + Respiratory
Fibrin deposition + Neutrophilic inflammation
What animals are susceptible to edema disease?
Between 6 to 14 weeks
Dietary changes at weaning
What does the bacteria responsible for edema disease produce?
What is the characteristic signs of edema disease?
Incoordination + Poor balance + Weakness + Tremors
What is the pathogenesis of Edema disease?
Bacteria proliferate in NI
Causes vascular endothelial injury of arteries
Fluid loss + Edema
What is often the cause of EHEC infection?
Contaminated ground beef
Not a naturally occurring disease
What is the pathogenesis of EHEC?
Bacteria produces a shiga-toxin
Contains plasmid encoding for hemolysin
Produces hemorrhagic colitis
What animals does EPEC/AEEC infect?
What gross lesions are present with EPEC/AEEC?
Dilated + Fluid filled intestinal tract
How does pathogenesis of EPEC/AAEC occur?
Intimin facilitates attachment to enterocytes
Effacement of surface microvilli + alters tight junction proteins
Loss of glycocalyx
What does EPEC/AAEC cause?
What is the second most common food borne pathogen?
What are the serovars of salmonella seen in animals?
What are the three forms of salmonellosis?
What is different about Salmonella Typhimurium + Cholerasuis?
Produced toxins blocked closure of Cl channels
Result in secretory diarrhea + malabsorption
What is the pathogenesis of a Salmonella infection?
Survive phagosome environment by producing nitrate transporter
Colonize regional lymph nodes
What toxins does Salmonella produce?
What can cause Peracute Salmonella septicemia?