What does the parvovirus type 2 infect in regards to cell type?
Dividing cells in the crypts of the intestines
What type of tropism does parvovirus type 2 have?
Where does initial replication occur in parvovirus?
What are the early lesions seen with Parvoviral enteritis?
What are the late stage lesions seen with Parvoviral enteritis?
Fibrinous exudate in lumen
Flaccid segments of SI
Depletion of bone marrow
What late lesion is only seen in dogs with parvoviral enteritis?
What happens to cats when they are infected with parvovirus type 2 in utero?
What causes cerebellar hypoplasia in cats that get an in utero parvo virus infection?
Alteration of differentiation of layers in cerebellum at organogenesis
What is seen upon histological examination of parvoviral enteritis?
Villus atrophy due to crypt destruction
Intranuclear basophilic inculsion bodies
Enterocytes + Lymphocytes infected
What are other names for parvoviral enteritis in cats + minks + raccoons?
What dog breeds are at an increase risk of parvo virus infection?
Canine parvovirus syndrome: < 2 weeks
Necrosis of rapidly dividing tissues
Canine parvovirus syndrome: 3 to 8 weeks
Canine parvovirus syndrome: > 8 weeks
What is the gross presentation of parvoenteritis?
Segments of SI diffusely reddened
Serosal surface is roughened + faintly granular + petechiated
What is the cause of minute virus of canids?
Canine Parvovirus Type 1
What is present in minute virus of canids?
Myocarditis + Respiratory disease
When does minute virus of canids cause fetal death?
If infection occurs at 25 to 35 days
What causes feline infectious peritonitis?
Feline enteric mutated coronavirus
What are the two forms of FIP?
Describe: Dry form of FIP
No effusion occurs
Describe: Wet Form of FIP
What cell type does feline enteric mutated coronavirus infect?
Where does inital replication of feline enteric mutated coronavirus occur?
What is the pathogensis of FIP?
Intital replication in lyphoid tissue
Carry virus systemic
Endothelial cells activated due to upregulation of MHC II
What is the gross presentation of the wet form of fibrinous polyserositis?
Fibrin strands between viscera
Mats of fibrin on organ surfaces
White linear serpentine tracts in mesentery
Small nodules of intestinal serosa + surface of kidney
What causes the white linear serpentine tracts in FIP?
Type II hypersensitivity
due to immune complexes
What is the bacterial cause of histiocytic ulcerative colitis?
Suggest that it might be E. Coli
What population of dogs tend to get histiocytic ulcerative colitis?
Younger then 2 years
What gross lesions are seen with histiolytic ulcerative colitis?
Raised ulcerative nodules in colon
(Can be regional or generalized)
What is the histopathology of histiocytic ulcerative colitis?
Marked inflammation reaction (Composed of macrophages + intracytoplasmic PAS postive material)
In lamina propria of mucosa
What is the fungal cause of canine histoplasmosis?
Where is canine histoplasmosis most commmonly seen?
Mississippi river valleys
How are dogs infected with canine histoplasmosis?
Yeast is inhaled or ingested
Replicates in macrophages
Causes necrosis + granulomatous inflammation
What does the GI form of canine histoplasmosis look like grossly?
Mucosa is corrugated + thickened with ulceration
Granulomas in liver
Where can you see the microorgranism when a canine histoplasmosis infection is occurring?
Inside macrophages of lamina proria or ileum and colon
What organism causes salmon poisoning?
What is the basic life cyle of a neorickettsia hemlinthoeca?
Lives in a trematode
Salmon ingested by a dog
What does neorickettsia hemlintoeca cause in a dog?
Necrosis of the GALT near the ileocecal valve
What gross lesions are seen with salmon poisoning?
Hemorrhagic + Granulomatous enterocolitis
What provides a diagnosis of salmon poisoning?
Macrophages containing Giemsa OR Gram-stained elementary bodies
How long does it take a dog to die from salmon poisoning?
What causes canine multifocal eosinophilic enteritis?
Larvae of Toxocara canis
At what age is canine multifocal eosinophilic enteritis most common?
Younger than 4 years
What happens when larvae of the Toxocara are in the mucosa in the GI tract?
What is the pathogenesis of Canine multifocal eosinophilic enteritis?
Invade mucosa of stomach + SI
Enter lymph vessels OR portal vein
Travel to liver + lung
L3 coughed up + swallowed
Mature/adult develops GI tracts
What is the characteristics of inflammatory bowel disease?
What breed are predisposed to inflammatory bowel disease?
What is the cause inflammatory bowel disease?
What can inflammatory bowl disease in cats lead to?
What dog breeds are predisposed to difffuse eosinophilic gastroenteritis?
Describe: Diffuse eosinophilic gastroenteritis
Increase in tissue + circulating eosinophilia
Suggests an hypersensitivity reaction
What gross lesions are present in diffuse eosinophilic gastroenteritis?
What is canine senile gastrointestinal amyloidosis characterized by?
Amyloid deposition in/around vessels of submucosa + muscularis layers
What disease processes are seen with canine senile GI amyloidosis?
No dysfunction seen
What does feline ulcerative colitis look like?
Histiocytic uclerative colitis in dogs
What does lymphagiectasia cause?
Protein-losing enteropathy in dogs
What is the cause of congenital lymphangiectasia?
Developmental disorders of lymphatics vessels
What is the cause of acquired lymphangiectasia?
Lymph vessels obstruction
What gross lesions are seen with lymphangiectasia?
Thickened mucosa with dialated lymphatics + lacteals in intestine
What can idiopathic intestinal lymphangiectasia lead to? Why?
Ascites due to protein-losing enteropathy
What is ileus?
Paralytic ileus is non-mechanical hypotitity resulting in functional obstruction
What can cause Ileus?
Paralysis of the wall
Abnormal stimulation of splanchinic n.
Vitamin B-Complex deficiency
Term: Trapped section in intussuception
Term: Enveloping portion in intussusception
What breed of horse most commonly gets enteroliths?
Older than 4 years ofl
What are enteroliths most commonly made of?
Around a central nidus
Where do enteroliths normally lodge?
-- or --
What commonly result in strictures?
Narrowing of the lumen of a canal
Normally due to healing of a scar
What is a common cause of a stricture in pigs?
Sequela of Salmonellosis
Thrombosis of cranial hemorrhoidal artery
What is atresia?
Occulsion of intestinal lumen as the result of anomalous development
How does atresia occur?
Result from lesions in fetal blood vessels
Most of the time caused by malpositioning + secondary vascular accidents/ischemia
What are the forms of Megacolon?
-- and --
What animals does the congenital form of megacolon occur in
What is the cause of congenital megacolon?
Developmental lack of myenteric plexus secondary to failure of migration of neuroblasts from neural crest
What histological lesions are seen with equine overo?
What occurs with equine overo megacolon?
Die within 72 hours of birth
What causes acquired megacolon?
Secondary to damage to the colonic inervation