LEC 14 - GI V Flashcards Preview

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Flashcards in LEC 14 - GI V Deck (78):
1

What does the parvovirus type 2 infect in regards to cell type?

Dividing cells in the crypts of the intestines 

2

What type of tropism does parvovirus type 2 have?

Radiomimetric 

3

Where does initial replication occur in parvovirus?

Lymphoid tissues

4

What are the early lesions seen with Parvoviral enteritis?

Lymphoid depletion 

Thymic involution

5

What are the late stage lesions seen with Parvoviral enteritis?

Red 

Fibrinous exudate in lumen 

Flaccid segments of SI 

Serositis 

Depletion of bone marrow 

 

6

What late lesion is only seen in dogs with parvoviral enteritis?

Coagulative lymphadenitis 

7

What happens to cats when they are infected with parvovirus type 2 in utero?

Cerebellar hypoplasia

8

What causes cerebellar hypoplasia in cats that get an in utero parvo virus infection?

Alteration of differentiation of layers in cerebellum at organogenesis 

9

What is seen upon histological examination of parvoviral enteritis?

Villus atrophy due to crypt destruction 

Intranuclear basophilic inculsion bodies 

Enterocytes + Lymphocytes infected

10

What are other names for parvoviral enteritis in cats + minks + raccoons?

Panleukopenia 

Cat distemper 

Feline enteritis 

Mink enteritis 

11

What dog breeds are at an increase risk of parvo virus infection?

Rottweilers 

Dobermans 

12

Canine parvovirus syndrome: < 2 weeks

Generalized disease 

Necrosis of rapidly dividing tissues 

 

13

Canine parvovirus syndrome: 3 to 8 weeks 

Myocarditis 

14

Canine parvovirus syndrome: > 8 weeks 

Hemorrhagic enteritis 

Panleukopenia

15

What is the gross presentation of parvoenteritis?

Segments of SI diffusely reddened 

Serosal surface is roughened + faintly granular + petechiated

Mucosa necrotic 

Sloughing mucosa 

16

What is the cause of minute virus of canids?

Canine Parvovirus Type 1

17

What is present in minute virus of canids?

Myocarditis + Respiratory disease 

18

When does minute virus of canids cause fetal death?

If infection occurs at 25 to 35 days

19

What causes feline infectious peritonitis?

Feline enteric mutated coronavirus 

20

What are the two forms of FIP?

Wet 

Dry 

21

Describe: Dry form of FIP

No effusion occurs 

22

Describe: Wet Form of FIP 

Fibrinous polyserositis 

23

What cell type does feline enteric mutated coronavirus infect?

Macrophages 

24

Where does inital replication of feline enteric mutated coronavirus occur?

Lymphoid tissues

25

What is the pathogensis of FIP?

Intital replication in lyphoid tissue 

Macrophages infection 

Carry virus systemic

Endothelial cells activated due to upregulation of MHC II 

Non-neutralizing Ab's 

Immunocomplexes form 

Vasculitis 

 

26

What is the gross presentation of the wet form of fibrinous polyserositis?

Fibrin strands between viscera 

Mats of fibrin on organ surfaces 

White linear serpentine tracts in mesentery 

Small nodules of intestinal serosa + surface of kidney 

27

What causes the white linear serpentine tracts in FIP?

Type II hypersensitivity 

due to immune complexes 

28

What is the bacterial cause of histiocytic ulcerative colitis?

Suggest that it might be E. Coli 

29

What population of dogs tend to get histiocytic ulcerative colitis? 

Boxer dogs 

Younger then 2 years 

30

What gross lesions are seen with histiolytic ulcerative colitis?

Raised ulcerative nodules in colon 

Lymphadenopathy 

(Can be regional or generalized) 

31

What is the histopathology of histiocytic ulcerative colitis?

 Ulceration

Marked inflammation reaction (Composed of macrophages + intracytoplasmic PAS postive material) 

In lamina propria of mucosa 

32

What is the fungal cause of canine histoplasmosis?

Histoplasma capsulatum 

33

Where is canine histoplasmosis most commmonly seen?

Ohio 

Mississippi river valleys

34

How are dogs infected with canine histoplasmosis?

Yeast is inhaled or ingested 

Invades tissues 

Replicates in macrophages 

Causes necrosis + granulomatous inflammation

35

What does the GI form of canine histoplasmosis look like grossly?

Mucosa is corrugated + thickened with ulceration 

Granulomas in liver 

Hepatomegaly 

Lymphadenomegaly 

36

Where can you see the microorgranism when a canine histoplasmosis infection is occurring?

Inside macrophages of lamina proria or ileum and colon 

37

What organism causes salmon poisoning?

Neorickettsia hemlinthoeca 

38

What is the basic life cyle of a neorickettsia hemlinthoeca?

Lives in a trematode 

Affects salmon  

Salmon ingested by a dog 

39

What does neorickettsia hemlintoeca cause in a dog?

Necrosis of the GALT near the ileocecal valve

40

What gross lesions are seen with salmon poisoning?

Hemorrhagic + Granulomatous enterocolitis

41

What provides a diagnosis of salmon poisoning?

Macrophages containing Giemsa OR Gram-stained elementary bodies 

 

42

How long does it take a dog to die from salmon poisoning?

10 days 

43

What causes canine multifocal eosinophilic enteritis? 

Larvae of Toxocara canis 

44

At what age is canine multifocal eosinophilic enteritis most common?

Younger than 4 years 

45

What happens when larvae of the Toxocara are in the mucosa in the GI tract? 

Granulomatous nodules 

46

What is the pathogenesis of Canine multifocal eosinophilic enteritis? 

Larvae ingested 

Invade mucosa of stomach + SI 

Enter lymph vessels OR portal vein 

Travel to liver + lung 

L3 coughed up + swallowed 

Mature/adult develops GI tracts 

47

What is the characteristics of inflammatory bowel disease? 

Lymphoplasmacytic enteritis 

 

48

What breed are predisposed to inflammatory bowel disease?

Basejii 

German Shepherd 

49

What is the cause inflammatory bowel disease? 

Unknown 

50

What can inflammatory bowl disease in cats lead to? 

Alimentary lymphoma 

51

What dog breeds are predisposed to difffuse eosinophilic gastroenteritis? 

German shepherd 

52

Describe: Diffuse eosinophilic gastroenteritis 

Increase in tissue + circulating eosinophilia 

Suggests an hypersensitivity reaction 

53

What gross lesions are present in diffuse eosinophilic gastroenteritis?

None 

54

What is canine senile gastrointestinal amyloidosis characterized by?

Amyloid deposition in/around vessels of submucosa + muscularis layers

55

What disease processes are seen with canine senile GI amyloidosis? 

No dysfunction seen 

56

What does feline ulcerative colitis look like?

Histiocytic uclerative colitis in dogs 

57

What does lymphagiectasia cause?

Protein-losing enteropathy in dogs 

58

What is the cause of congenital lymphangiectasia?

Developmental disorders of lymphatics vessels 

59

What is the cause of acquired lymphangiectasia?

Lymph vessels obstruction 

60

What gross lesions are seen with lymphangiectasia?

Thickened mucosa with dialated lymphatics + lacteals in intestine 

61

What can idiopathic intestinal lymphangiectasia lead to? Why?

Ascites due to protein-losing enteropathy 

 

62

What is ileus?

Paralytic ileus is non-mechanical hypotitity resulting in functional obstruction 

 

63

What can cause Ileus?

Paralysis of the wall 

Peritonitis 

Abnormal stimulation of splanchinic n. 

Toxemia 

Vitamin B-Complex deficiency 

Uremia 

Tetanus 

64

Term: Trapped section in intussuception 

Intussusceptum 

65

Term: Enveloping portion in intussusception 

Intussuscipiens 

66

What breed of horse most commonly gets enteroliths?

Arabian breeds 

Older than 4 years ofl 

67

What are enteroliths most commonly made of? 

Ammonium-magnesium phosphate 

(Struvite)

Around a central nidus 

68

Where do enteroliths normally lodge?

Pelvic flexure 

-- or -- 

Transverse colon 

69

What commonly result in strictures?

Narrowing of the lumen of a canal 

Normally due to healing of a scar 

70

What is a common cause of a stricture in pigs?

Sequela of Salmonellosis 

Thrombosis of cranial hemorrhoidal artery 

71

What is atresia?

Occulsion of intestinal lumen as the result of anomalous development 

72

How does atresia occur?

Result from lesions in fetal blood vessels 

Most of the time caused by malpositioning + secondary vascular accidents/ischemia 

73

What are the forms of Megacolon?

Acquired 

-- and -- 

Congenital 

 

74

What animals does the congenital form of megacolon occur in 

Pigs 

Dogs 

Cats 

Overo foals 

75

What is the cause of congenital megacolon?

Developmental lack of myenteric plexus secondary to failure of migration of neuroblasts from neural crest 

76

What histological lesions are seen with equine overo?

Intestinal aganglionosis 

77

What occurs with equine overo megacolon?

Colic develops 

Die within 72 hours of birth 

78

What causes acquired megacolon?

Secondary to damage to the colonic inervation 

Atresia ani