LEC 3 - Reproductive Drugs - Males Flashcards Preview

Pharmacology II > LEC 3 - Reproductive Drugs - Males > Flashcards

Flashcards in LEC 3 - Reproductive Drugs - Males Deck (34):
1

What type of hormone are gonadotropins?

Glycoprotiens

 

2

How do gonadotropins compare across species?

Identical alpha subunits 

Different beta subunits

3

What are the gonadotropins?

FSH 

LH 

CG 

4

What is the specific prostaglandin in reproduction?

PGF2alpha

5

Where are the steroid reproducive hormones produced?

Throughout the reproductive tract

GOnads 

Uterus/placenta

Hypothalamus

6

What are the characteristics of the steroid reproductive hormones?

Short 1/2 lives 

Long duration of action 

7

What is the characteristic of the GnRH cycle?

Plasma GnRH concentrations oscillate with peaks occurring every 60 to 90 minutes

8

What does GnRH (from the hypothalamus) stimulate to happen in the anterior pituitary?

LH + FSH secretion

9

What does LH from the anterior pituitary do?

Stimulate interstitial cells 

Secrete testosterone 

10

What does FSH from the anterior pituitary do?

Stimulate seminiferious tubules 

Sustentacular cells 

Secrete Inhbin 

11

What does inhibit from the seminiferous tubules do?

Inhibits secetion of FSH 

12

What does testosterone from the interstitial cells do?

Inhibit GnRH secretion 

 

13

Intersitital cells aka 

Leydig cells

14

Sustentacular cells aka 

Sertoli cells

15

What are the two main uses for chorionic gonadotropin in males?

Correction of cryptorchidism 

Determination of remnant testicualr tissue in castrated cats/dogs

16

What are the hormones that control testicular descent?

Insulin-like GF 3 

Anti-mullarian Hormone 

Adrogens

17

When an animal is given hCG where does it act?

Interstitial cells

18

When does hCG have to be given inorder to aid in cryptorchisism?

during time of proper decent 

first 8 weeks of life 

19

How is GnRH administered?

Digested in GI tract 

So given IM 

20

How is human chorionic gonadotropin adminstered?

Digested in GI tract 

IM adminstration 

21

How is hCG handled in the body?

Metabolized by the liver 

To testes in males 

To ovaries in females 

22

What are the adverse reactions to hCG?

Hypersensitivity reaction 

(due to being from humans) 

23

How is hCG used to deteremine whether there is any remnant testicular tissue?

Draw blood 

Give hCG/GnRH 

Wait 60 to 90 minutes 

Measure T = should be constant in castrated animal 

24

What is recommened for medical treatment in cases of benign prostatic hyperplasia in breeders?

Finasteride 

-- and --

Progestin 

25

Where does finasteride act in cases of benign prostatic hyperplasia?

5alpha - reductase 

26

Where do progestins act in cases of benign prostatic hyperplasia?

5alpha - dihydrotestosterone 

27

How is finasteride given?

PO 

 

28

How is finasteride handled by the body?

Metabolized by the liver 

90% bound to plasma proteins 

29

What does finasteride have interactions with?

Anticholinergics 

30

What does finasteride do to hormone levels?

Lowers DHT but not testosterone 

Reduces prostatic diameter 

31

What are the two progestins?

Medroxyprogesterone acetate 

Megestrol acetate 

32

What is the progestin used in vet medicine?

Megastrol acetate 

 

33

How is megaestrol acetate handled by the body?

Absorbed in the GI tract 

Fully metabolized by the liver 

34

Whats improtant to note when handling progestins?

females need to be careful 

Increased risk of mammary/uterine cancers 

Fetal abnormalities