LEC 4 - Reproductive Drugs - Females Flashcards Preview

Pharmacology II > LEC 4 - Reproductive Drugs - Females > Flashcards

Flashcards in LEC 4 - Reproductive Drugs - Females Deck (47):
1

What are the four cylces of the female reproductive tract.

Estrous/Behavioral 

Ovarian 

Uterine 

Hormonal 

2

What are the parts of the Estrous cycle?

Proestrus 

Estrus 

Metestrus 

Diestrus 

Anestrus

3

What are the parts of the ovarian cycle?

Follicular 

Luteal

4

What are the parts of the uterine cycle?

Menes 

Proliferation 

Secretory

5

What are the parts of the hormonal cycle?

Estradiol 

Progesterone

6

What two peaks occur for ovulation to happen?

Estrogen > LH 

7

What peaks post ovulation?

Progesterone

8

What are the two nuclei in the hypothalamus that are responsible for female reproductive regulation?

Tonic Nuclei 

-- and -- 

Surge Nuclei

9

What is occurring hormonally during the follicular phase?

Inhibin from follicle is inhibiting pituitary FSH?LH

Surge nuclei stimulating pituitary to release FSH/LH 

Estradiol stimulating surge nuclei

10

What is occurring hormonally during the ovulatory phase?

estradiol is stimulation pituitary and the surge nuclei

LH stimulating hte follicle 

11

What is occurring in the luteal phase of ovulation?

Progesterone inhibiting the surge nuclei and pit. 

LH is less so coming form the PIT 

12

What are the indications for using GnRH in females?

Treatment of follicular cysts - cows/dogs 

Synchronization of estrus - cows

Detect ovarian remnants - cats 

13

What are the indications for using hCG in females?

Treatment of follicular cysts - cows 

Induction of estrus - gilts and sows 

 

14

What are the characteristics of hCG?

Stimulate LH 

Need RX to get

15

What are the characteristics of eCG?

Stimualte FSH 

OTC drug 

16

What are the common causes of follicular cysts in cattle?

Lack of synchorny between follicle maturation + LH surge

= Continuous high systemic estradiol levels 

17

What happens to the cow early on with follicular cysts?

Endometrial edema 

Cystic hyperplasia 

18

What happens chronically to a cow with follicular cysts?

Mucometra 

Endometrial atrophy

Squamous metaplasia

Myometrial atony 

Cystic gartner's duct 

bartholin's glands

19

What does progestins do when given to a female?

Prolong diestrus by effectively maintaining high progesterone levels

20

Indications: Medroxyprogesterone acetate

Suppression of estrus 

Dogs + Cats + Horse 

21

Indications: Megestrol acetate

Suppression of estrus 

Dogs + Cats

22

Indications: Progesterone 

Synchornizing estrus - Beef/Dairy cattles + sheep 

23

What is altrenogest used for?

Luteal insufficency (Dogs + horses) 

Synchronization (Horses + Sows) 

24

How sis altrenogest handled by the body?

Given PO 

Eliminated in the urine 

25

What is a contraindication when using altrenogest?

Activation of microsomal enzymes by Rifampin can reduce the acitivity of the drug 

26

What is different about the maintence of the CL in cattle?

CL produces oxytocin 

Oxytocin stimulates uterues to produce PGF2alpha

PGF2alpha shuts down CL 

Utreus takes over in producing progesterone 

27

What are the indications for using PGF2alpha?

Lysis of luteal cysts 

Synchronization of estrus - cows

Estrus induction - horses

Abortions - Dairy cattle, sheep, goats, small animals 

Induction of partution - swine 

Hydro/Mucometra - sheep/goat 

Pyometra - Cows 

Slient estrus - Lactating cows 

28

PGF2 alpha abortion use window: Dog 

No PGF2alpha sensitivity 

29

PGF2 alpha abortion use window: Cat 

No sensitivity 

30

PGF2 alpha abortion use window: Pig

Insensitive to PGF2alpha 10 to 12 days post ovulation 

31

PGF2 alpha abortion use window: Pigs

10 to 12d post-ovulation

32

PGF2 alpha abortion use window: Sheep + Cow + Horse

4 to 6 days post ovulation

33

How is PGF2alpha adminstered?

IM NEVER IV 

34

How is PGF2alpha handled by the body?

Metabolized by the lungs 

Meat withdrawl time is 0 

35

PGF2alpha adverse reactions: Cattle

Transient increased temperature 

Injection site infections 

36

PGF2alpha adverse reactions: Horses

Trasient decreased temperature 

Increased RR/HR 

Ataxia 

Abdominal pain 

laying down 

 

37

PGF2alpha adverse reactions: Swine 

Increased RR 

Dyspnea 

Abdominal muscle spasms 

Nesting 

VOcalization 

Salivation 

Pruiritis

38

When should PGF2alpha not be given?

Closed pyometras 

RAO/Asthma

39

What is the basic synchronization protocol?

Give CIDR device (progesterone) 

6 days later - Give dinoprost 

1 day later - remove CIDR 

40

What is important when talking to the client about doing a synchronization protocol and obtaining the supplies?

CIDR = OTC 

Dinoprost = RX

41

what are the indications for oxytocin use?

Induction/enhancement of uterine contractions 

Retained placenta

Postpartum metritis 

Uterine involution following the correction of prolapsed uterus 

Agalactia 

42

What two reflexes involve oxytocin?

Milk ejection 

-- and -- 

Ferguson

43

What cell type does ocytocin act on?

Myoepithelial cells 

44

Where does oxytocin naturally come form?

Neurohypophysis

45

How is oxytocin adminstered?

IV 

IM 

SC 

IN 

46

What is important about the timing of oxytocin administration when giving it during labor?

Give before uterine inertia 

47

What are contrindications for using oxytocin?

Utrine cramping/discomfort/rupture 

Hypersensitivity