Lec 31 Flashcards

(43 cards)

1
Q

What is the function of the ovaries?

A

Primary sex organ that produce egg each month and sex hormones

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2
Q

What is the function of oviducts/fallopian tubes?

A

Conduct egg , site of fertilisation

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3
Q

What is the function of the uterus/womb ?

A

It houses developing embryo and fetus
it consists of endometrium , myometrium , premetrium
cervical cancer

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4
Q

What is the function of the vagina?

A

1- It receives the penis during copulation
2- serves as birth canal + exit for menstrual flow

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5
Q

Mitosis of primary Ogen occurs during ——— until——— ( peak of 7 million oocytes ) then ceases

A

Fetal life
Midgestion

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6
Q

The primary oocyte begins its first meiotic division in the ?

A

Utero

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7
Q

By puberty there are approximately —— oocytes only 400 follicles ovulate in women

A

400,000

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8
Q

At the time of ovulation, the primary oocyte completes ———— producing the ——— and a —— it’s arrests in metaphase of 2 meiotic division

A

the first meiotic division ( meiosis I )
first polar body
secondary oocyte

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9
Q

What causes completion of 2 meiotic division & expulsion of a second polar body ?

A

Sperm penetration / fertilisation

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10
Q

What happens before birth ?

A

Oogonium ( 2n ) undergoes mitosis so it becomes a primary oocyte ( 2n ) that arrests in prophase I

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11
Q

What happens after puberty ?

A

Primary oocyte continues meiosis-> turns into secondary oocyte with polar body ( 1n ) and arrests in metaphase II
Ovulation & sperm entry -> meiosis , fertilisation-> zygote ( 2n ) with polar body ( 1n )

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12
Q

What happens during the ovarian cycle?

A

1- follicular phase ( FSH dependent )
2- ovulation ( LH dependent )
3- luteal phase ( LH dependent )

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13
Q

Follicles are made up of ?

A

Oocyte & follicular cells

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14
Q

What is the function of follicular cells?

A

Differentiate to granulosa & thecal cells , producing female sex hormones & fluid

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15
Q

What is the result of changing levels of FSH and LH from the anterior pituitary ?

A

Changes in the ovary

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16
Q

The CNS lets the hypothalamus produce —— which produces FSH and LH in the anterior pituitary

A

GnRH

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17
Q

When the anterior pituitary produces FSH it goes to the ——— , which produces —— & ——

A

Granulosa cell
Progestins
Estrogens

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18
Q

When the anterior pituitary produces LH it goes to the —— , which produces ——

A

Thecal cell
Estrogens

19
Q

When the estrogen produced from the granulosa cell and thecal cell , go to the anterior pituitary / hypothalamus , to ————

A

Decrease / increase LH secretion

20
Q

When the thecal cell receives LH it either produces —— or —— , which go to granulosa cell to inhibin FSH secretion from the anterior pituitary

A

Estrogens
Androgens

21
Q

The menstrual cycle include 2 cycles :

A

1- ovarian cycle { follicular phase , ovulation , luteal phase }
2- endometrial cycle { proliferative phase , secretory phase , menstruation }

22
Q

When does proliferative phase occur ?

A

During: Ovarian follicular phase

23
Q

What stage happens before the proliferative phase ?

A

menstruation ( menses phase ) happens

24
Q

What happens during the proliferative phase?

A

Increase in estradiol -> stimulates growth/proliferation of stratum functionale of endometrium

25
What happens during ovarian cycle?
1- follicular phase ( lasts from 1 - day 13 of cycle ) 2- ovulation ( a women usually ovulates 1 ovum a month ) 3- luteal phase Before
26
What happens during the follicular phase?
FSH -> growth and maturation of follicles ( only 1 will become mature ) Granulosa & thecal cells -> secrete estradiol ( peaks 2 days before ovulation ) Granulosa cells stimulated by FSH , thecal cells stimulated by LH
27
What does the rapid increase in estradiol secretion lead to?
Positive feedback effect-> rapid LH secretion -> LH surge
28
What happens during ovulation?
1- Completion of meiosis I 2- rupture Graafian follicle wall ( day 14 ) 3- ovulation 4- expulsion of secondary oocyte ( with first polar body ) out of the ovaries into fallopian tube ★ if ova is fertilised by a sperm it completes the second meiotic division -> formation of second polar body
29
What happens during the luteal phase?
1- LH stimulates empty follicle ( corpus luteum ) 2- secretion of estradiol & progesterone + inhibin ( which inhibits FSH only ) 3- negative feedback inhibition of FSH and LH 4- prevent the development of a new follicle 5- regression of corpus luteum ( lifespan ~14±2 ) 6- decrease in estrogen & progesterone 7- menstruation
30
What is the phase after the proliferative phase?
Secretory phase ( occurs during ovarian luteal phase )
31
What happens in the secretory phase ?
1- increase in progesterone -> stimulates development of uterine glands 2- the effects of increased estradiol & progesterone occur {1. endometrium is thick vascular spongy in appearance 2. Uterine glands become engorged with glycogen lipids proteins } 3- endometrium ready to accept & nourish embryo
32
What results in menstruation ?
Decrease in estradiol & progesterone levels during late luteal phase
33
What’s the process of menstruation
1- Arteries that supply the lining of uterus restrict & capillaries are weakened 2- damaged vessels detach layers of uterine lining { blood , mucus , degenerative tissue } descend from uterus
34
What is the first menstrual period that usually starts at 11-14 yrs
Menarche
35
If menarche didn’t occur at 16 yrs / uterine cycle was interrupted for more than 6 mnths without pregnancy this happens
Amenorrhea
36
What causes amenorrhea ?
1- Non-functional ovaries 2- Developmental abnormalities 3- weight loss 4- excessive exercise
37
The cessation of menstrual cycle
Menopause
38
Why does menopause occur ? And when ?
Because ovaries are not functioning anymore 45 - 55 yrs
39
Bothe estrogen & progesterone are required for —— development
Breast
40
What are the functions of estrogen & progesterone
1- help maintain endometrium during pregnancy 2- help suppress gonadotropin ( FSH , LH ) secretion 3- inhibit prolactin secretion
41
—— is essential for normal development & function of female reproductive organs
Estrogen
42
—— is responsible for development & maintenance of female secondary sexual characteristics
Estrogen
43
What are female secondary sexual characteristics?
1- less body & facial hair 2- more fat under skin to give rounded appearance 3- enlargement of pelvic girdle & cavity to give wider hips